業績をさがす - researchmap

Modeling lethal X-linked genetic disorders in pigs with ensured fertility: Hitomi Matsunari, Masahito Watanabe, Kazuaki Nakano, Shin Enosawa, Kazuhiro Umeyama, Ayuko Uchikura, Sayaka Yashima, Toru Fukuda, Nikolai Klymiuk, Mayuko Kurome, Barbara Kessler, Annegret Wuensch, Valeri Zakhartchenko, Eckhard Wolf, Yutaka Hanazono, Masaki Nagaya, Akihiro Umezawa, Hiromitsu Nakauchi, Hiroshi Nagashima

Proceedings of the National Academy of Sciences of the United States of America 115(4) 708-713 2018年1月23日査読有り

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Lysine-specific demethylase 1 inhibitors prevent teratoma development from human induced pluripotent stem cells: Naoki Osada, Jiro Kikuchi, Takashi Umehara, Shin Sato, Masashi Urabe, Tomoyuki Abe, Nakanobu Hayashi, Masahiko Sugitani, Yutaka Hanazono, Yusuke Furukawa

Oncotarget 9(5) 6450-6462 2018年査読有り

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Production and rearing of germ-free X-SCID pigs: Hiromasa Hara, Hiroaki Shibata, Kazuaki Nakano, Tomoyuki Abe, Hideki Uosaki, Takahiro Ohnuki, Shuji Hishikawa, Satoshi Kunita, Masahito Watanabe, Osamu Nureki, Hiroshi Nagashima, Yutaka Hanazono

Experimental Animals 67(2) 139-146 2018年査読有り

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Swine used in the medical university: Overview of 20 years of experience: Eiji Kobayashi, Yutaka Hanazono, Satoshi Kunita

Experimental Animals 67(1) 7-13 2018年査読有り

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CD34-negative hematopoietic stem cells show distinct expression profiles of homing molecules that limit engraftment in mice and sheep: Tomoyuki Abe, Yoshikazu Matsuoka, Yoshikazu Nagao, Yoshiaki Sonoda, Yutaka Hanazono

INTERNATIONAL JOURNAL OF HEMATOLOGY 106(5) 631-637 2017年11月査読有り

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CRISPR/Cas9-mediated genome editing via postnatal administration of AAV vector cures haemophilia B mice: Tsukasa Ohmori, Yasumitsu Nagao, Hiroaki Mizukami, Asuka Sakata, Shin-ichi Muramatsu, Keiya Ozawa, Shin-ichi Tominaga, Yutaka Hanazono, Satoshi Nishimura, Osamu Nureki, Yoichi Sakata

SCIENTIFIC REPORTS 7(1) 4159 2017年6月査読有り

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A swine model of acute thrombocytopenia with prolonged bleeding time produced by busulfan: ABE Tomoyuki, KONO Shota, OHNUKI Takahiro, HISHIKAWA Shuji, KUNITA Satoshi, HANAZONO Yutaka

Experimental Animals 345-351 2016年11月査読有り

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Ultra-Deep Bisulfite Sequencing to Detect Specific DNA Methylation Patterns of Minor Cell Types in Heterogeneous Cell Populations: An Example of the Pituitary Tissue: Yoshikazu Arai, Hisho Fukukawa, Takanori Atozi, Shoma Matsumoto, Yutaka Hanazono, Hiroshi Nagashima, Jun Ohgane

PLOS ONE 11(1) e0146498 2016年1月査読有り

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A Long-Term Follow-Up Study on the Engraftment of Human Hematopoietic Stem Cells in Sheep.: Abe T, Hanazono Y, Nagao Y

Experimental animals / Japanese Association for Laboratory Animal Science 63(4) 475-481 2014年7月査読有り

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MHC-Matched Induced Pluripotent Stem Cells Can Attenuate Cellular and Humoral Immune Responses but Are Still Susceptible to Innate Immunity in Pigs: Yoshihisa Mizukami, Tomoyuki Abe, Hiroaki Shibata, Yukitoshi Makimura, Shuh-hei Fujishiro, Kimihide Yanase, Shuji Hishikawa, Eiji Kobayashi, Yutaka Hanazono

PLOS ONE 9(6) e98319 2014年6月査読有り

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DNA methylation profiles provide a viable index for porcine pluripotent stem cells: Yoshikazu Arai, Jun Ohgane, Shuh-Hei Fujishiro, Kazuaki Nakano, Hitomi Matsunari, Masahito Watanabe, Kazuhiro Umeyama, Dai Azuma, Naomi Uchida, Nozomu Sakamoto, Tomohiro Makino, Shintaro Yagi, Kunio Shiota, Yutaka Hanazono, Hiroshi Nagashima

Genesis 51(11) 763-776 2013年11月査読有り

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Generation of Interleukin-2 Receptor Gamma Gene Knockout Pigs from Somatic Cells Genetically Modified by Zinc Finger Nuclease-Encoding mRNA: Masahito Watanabe, Kazuaki Nakano, Hitomi Matsunari, Taisuke Matsuda, Miki Maehara, Takahiro Kanai, Mirina Kobayashi, Yukina Matsumura, Rieko Sakai, Momoko Kuramoto, Gota Hayashida, Yoshinori Asano, Shuko Takayanagi, Yoshikazu Arai, Kazuhiro Umeyama, Masaki Nagaya, Yutaka Hanazono, Hiroshi Nagashima

PLOS ONE 8(10) e76478 2013年10月査読有り

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[Stem cell research using large animals].: Hanazono Y

[Rinsho ketsueki] The Japanese journal of clinical hematology 54(4) 329-335 2013年4月査読有り

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Generating Porcine Chimeras Using Inner Cell Mass Cells and Parthenogenetic Preimplantation Embryos: Kazuaki Nakano, Masahito Watanabe, Hitomi Matsunari, Taisuke Matsuda, Kasumi Honda, Miki Maehara, Takahiro Kanai, Gota Hayashida, Mirina Kobayashi, Momoko Kuramoto, Yoshikazu Arai, Kazuhiro Umeyama, Shuh-hei Fujishiro, Yoshihisa Mizukami, Masaki Nagaya, Yutaka Hanazono, Hiroshi Nagashima

PLOS ONE 8(4) e61900 2013年4月査読有り

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Generation of Naive-Like Porcine-Induced Pluripotent Stem Cells Capable of Contributing to Embryonic and Fetal Development: Shuh-hei Fujishiro, Kazuaki Nakano, Yoshihisa Mizukami, Takuya Azami, Yoshikazu Arai, Hitomi Matsunari, Rikiya Ishino, Takashi Nishimura, Masahito Watanabe, Tomoyuki Abe, Yutaka Furukawa, Kazuhiro Umeyama, Shinya Yamanaka, Masatsugu Ema, Hiroshi Nagashima, Yutaka Hanazono

STEM CELLS AND DEVELOPMENT 22(3) 473-482 2013年2月査読有り

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Hollow Fiber Vitrification Provides a Novel Method for Cryopreserving In Vitro Maturation/Fertilization-Derived Porcine Embryos: Miki Maehara, Hitomi Matsunari, Kasumi Honda, Kazuaki Nakano, Yasuhiro Takeuchi, Takahiro Kanai, Taisuke Matsuda, Yukina Matsumura, Yui Hagiwara, Norihisa Sasayama, Akio Shirasu, Masashi Takahashi, Masahito Watanabe, Kazuhiro Umeyama, Yutaka Hanazono, Hiroshi Nagashima

BIOLOGY OF REPRODUCTION 87(6) 133 2012年12月査読有り

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Maternal administration of busulfan before in utero transplantation of human hematopoietic stem cells enhances engraftments in sheep: Tomoyuki Abe, Shigeo Masuda, Yujiro Tanaka, Suguru Nitta, Yoshihiro Kitano, Satoshi Hayashi, Yutaka Hanazono, Yoshikazu Nagao

EXPERIMENTAL HEMATOLOGY 40(6) 436-444 2012年6月査読有り

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A Simplified In Vitro Teratoma Assay for Pluripotent Stem Cells Injected Into Rodent Fetal Organs.: Masuda S, Yokoo T, Sugimoto N, Doi M, Fujishiro SH, Takeuchi K, Kobayashi E, Hanazono Y

Cell medicine 3(1-3) 103-112 2012年1月査読有り

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Migration of cells from the yolk sac to hematopoietic tissues after in utero transplantation of early and mid gestation canine fetuses.: Shigeo Masuda, Satoshi Hayashi, Naohide Ageyama, Hiroaki Shibata, Tomoyuki Abe, Yoshikazu Nagao, Yutaka Hanazono

Transplantation 92(2) e5-6; author reply e6-7-6; author reply e6 2011年7月27日査読有り

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Induced pluripotent stem cells in long-QT syndrome.: Masuda S, Hanazono Y

The New England journal of medicine 364(2) 181; author reply 181-2 2011年1月査読有り

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Ex vivo expansion of human HSCs with Sendai virus vector expressing HoxB4 assessed by sheep in utero transplantation: Tomoyuki Abe, Shigeo Masuda, Hiroshi Ban, Satoshi Hayashi, Yasuji Ueda, Makoto Inoue, Mamoru Hasegawa, Yoshikazu Nagao, Yutaka Hanazono

EXPERIMENTAL HEMATOLOGY 39(1) 47-54 2011年1月査読有り

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Induced pluripotent stem cells in long-QT syndrome.: Masuda S, Hanazono Y

The New England journal of medicine 364(2) 181; author reply 181-2 2011年1月査読有り

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Intravascular Route Is Not Superior to an Intraperitoneal Route for In Utero Transplantation of Human Hematopoietic Stem Cells and Engraftment in Sheep: Yujiro Tanaka, Shigeo Masuda, Tomoyuki Abe, Satoshi Hayashi, Yoshihiro Kitano, Yoshikazu Nagao, Yutaka Hanazono

TRANSPLANTATION 90(4) 462-463 2010年8月査読有り

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Dual antitumor mechanisms of Notch signaling inhibitor in a T-cell acute lymphoblastic leukemia xenograft model: Shigeo Masuda, Keiki Kumano, Takahiro Suzuki, Taisuke Tomita, Takeshi Iwatsubo, Hideaki Natsugari, Arinobu Tojo, Makoto Shibutani, Kunitoshi Mitsumori, Yutaka Hanazono, Seishi Ogawa, Mineo Kurokawa, Shigeru Chiba

CANCER SCIENCE 100(12) 2444-2450 2009年12月査読有り

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Cotransplantation with MSCs improves engraftment of HSCs after autologous intra-bone marrow transplantation in nonhuman primates.: Shigeo Masuda, Naohide Ageyama, Hiroaki Shibata, Yoko Obara, Tamako Ikeda, Kengo Takeuchi, Yasuji Ueda, Keiya Ozawa, Yutaka Hanazono

Experimental hematology 37(10) 1250-1257 2009年10月査読有り

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Improved Efficacy and Safety of In Utero Cell Transplantation in Sheep Using an Ultrasound-Guided Method: Yoshikazu Nagao, Tomoyuki Abe, Hideaki Hasegawa, Yujiro Tanaka, Kyoko Sasaki, Yoshihiro Kitano, Satoshi Hayashi, Yutaka Hanazono

CLONING AND STEM CELLS 11(2) 281-285 2009年6月査読有り

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ERas Is Expressed in Primate Embryonic Stem Cells But Not Related to Tumorigenesis: Yujiro Tanaka, Tamako Ikeda, Yukiko Kishi, Shigeo Masuda, Hiroaki Shibata, Kengo Takeuchi, Makoto Komura, Tadashi Iwanaka, Shin-ichi Muramatsu, Yasushi Kondo, Kazutoshi Takahashi, Shinya Yamanaka, Yutaka Hanazono

CELL TRANSPLANTATION 18(4) 381-389 2009年査読有り

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Knockout serum replacement (KSR) has a suppressive effect on sendai virus-mediated transduction of cynomolgus ES cells: Yukiko Kishi, Makoto Inoue, Yujiro Tanaka, Hiroaki Shibata, Shigeo Masuda, Tamako Ikeda, Mamoru Hasegawa, Yutaka Hanazono

CLONING AND STEM CELLS 10(3) 307-312 2008年9月査読有り

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Sustained macroscopic engraftment of cynomolgus embryonic stem cells in xenogeneic large animals after in utero transplantation: Yujiro Tanaka, Shinichiro Nakamura, Hiroaki Shibata, Yukiko Kishi, Tamako Ikeda, Shigeo Masuda, Kyoko Sasaki, Tomoyuki Abe, Satoshi Hayashi, Yoshihiro Kitano, Yoshikazu Nagao, Yutaka Hanazono

STEM CELLS AND DEVELOPMENT 17(2) 367-381 2008年4月査読有り

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Variation in the Incidence of Teratomas After the Transplantation of Nonhuman Primate ES Cells Into Immunodeficient Mice: Yukiko Kishi, Yujiro Tanaka, Hiroaki Shibata, Shinichiro Nakamura, Koichi Takeuchi, Shigeo Masuda, Tamako Ikeda, Shin-ichi Muramatsu, Yutaka Hanazono

CELL TRANSPLANTATION 17(9) 1095-1102 2008年査読有り

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Improved safety of hematopoietic transplantation with monkey embryonic stem cells in the allogeneic setting.: Hiroaki Shibata, Naohide Ageyama, Yujiro Tanaka, Yukiko Kishi, Kyoko Sasaki, Shinichiro Nakamura, Shin-ichi Muramatsu, Satoshi Hayashi, Yoshihiro Kitano, Keiji Terao, Yutaka Hanazono

Stem cells (Dayton, Ohio) 24(6) 1450-7 2006年6月査読有り

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iPS-cell research using swine.: Hanazono Y

Nihon rinsho. Japanese journal of clinical medicine 73 Suppl 5 360-364 2015年6月査読有り

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Prevention of immune responses to human erythropoietin in cynomolgus monkeys (Macaca fascicularis).: Naohide Ageyama, Yutaka Hanazono, Hiroaki Shibata, Fumiko Ono, Takeyuki Nagashima, Yasuji Ueda, Yasuhiro Yoshikawa, Mamoru Hasegawa, Keiya Ozawa, Keiji Terao

The Journal of veterinary medical science 68(5) 507-10 2006年5月査読有り

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In vivo tumor formation from primate embryonic stem cells.: Asano T, Sasaki K, Kitano Y, Terao K, Hanazono Y

Methods in molecular biology (Clifton, N.J.) 329 459-467 2006年査読有り

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Use of simian immunodeficiency virus vectors for simian embryonic stem cells.: Asano T, Shibata H, Hanazono Y

Methods in molecular biology (Clifton, N.J.) 329 295-303 2006年査読有り

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Safe and efficient collection of cytokine-mobilized peripheral blood cells from cynomolgus monkeys (Macaca fascicularis) with human newborn-equivalent body weights.: Naohide Ageyama, Yutaka Hanazono, Hiroaki Shibata, Fumiko Ono, Hiromi Ogawa, Takeyuki Nagashima, Yasuji Ueda, Yasuhiro Yoshikawa, Mamoru Hasegawa, Keiya Ozawa, Keiji Terao

Experimental animals 54(5) 421-8 2005年10月査読有り

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Repair of infarcted myocardium mediated by transplanted bone marrow-derived CD34+ stem cells in a nonhuman primate model.: Toru Yoshioka, Naohide Ageyama, Hiroaki Shibata, Takanori Yasu, Yoshio Misawa, Koichi Takeuchi, Keiji Matsui, Keiji Yamamoto, Keiji Terao, Kazuyuki Shimada, Uichi Ikeda, Keiya Ozawa, Yutaka Hanazono

Stem cells (Dayton, Ohio) 23(3) 355-64 2005年3月査読有り

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Hematopoietic microchimerism in sheep after in utero transplantation of cultured cynomolgus embryonic stem cells: K Sasaki, Y Nagao, Y Kitano, H Hasegawa, H Shibata, M Takatoku, S Hayashi, K Ozawa, Y Hanazono

TRANSPLANTATION 79(1) 32-37 2005年1月査読有り

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Sustained transgene expression by human cord blood derived CD34+ cells transduced with simian immunodeficiency virus agmTYO(1)-based vectors carrying the human coagulation factor VIII gene in NOD/SCID mice: J Kikuchi, J Mimuro, K Ogata, T Tabata, Y Ueda, A Ishiwata, K Kimura, K Takano, S Madoiwa, H Mizukami, Y Hanazono, A Kume, M Hasegawa, K Ozawa, Y Sakata

JOURNAL OF GENE MEDICINE 6(10) 1049-1060 2004年10月査読有り

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High-level in vivo gene marking after gene-modified autologous hematopoietic stem cell transplantation without marrow conditioning in nonhuman primates.: Kyoji Ueda, Yutaka Hanazono, Hiroaki Shibata, Naohide Ageyama, Yasuji Ueda, Satoko Ogata, Toshiaki Tabata, Takeyuki Nagashima, Masaaki Takatoku, Akihiko Kume, Susumu Ikehara, Masafumi Taniwaki, Keiji Terao, Mamoru Hasegawa, Keiya Ozawa

Molecular therapy : the journal of the American Society of Gene Therapy 10(3) 469-77 2004年9月査読有り

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In vivo expansion of gene-modified hematopoietic cells by a novel selective amplifier gene utilizing the erythropoietin receptor as a molecular switch.: Takeyuki Nagashima, Yasuji Ueda, Yutaka Hanazono, Akihiro Kume, Hiroaki Shibata, Naohide Ageyama, Keiji Terao, Keiya Ozawa, Mamoru Hasegawa

The journal of gene medicine 6(1) 22-31 2004年1月査読有り

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Persistent phenotypic correction of central diabetes insipidus using adeno-associated virus vector expressing arginine-vasopressin in Brattleboro rats: J Ideno, H Mizukami, K Honda, T Okada, Y Hanazono, A Kume, T Saito, S Ishibashi, K Ozawa

MOLECULAR THERAPY 8(6) 895-902 2003年12月査読有り

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A soluble CAR-SCF fusion protein improves adenoviral vector-mediated gene transfer to c-Kit-positive hematopoietic cells: A Itoh, T Okada, H Mizuguchi, T Hayakawa, H Mizukami, A Kume, M Takatoku, N Komatsu, Y Hanazono, K Ozawa

JOURNAL OF GENE MEDICINE 5(11) 929-940 2003年11月査読有り

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Efficient gene transfer of a simian immunodeficiency viral vector into cardiomyocytes derived from primate embryonic stem cells: M Nagata, MA Takahashi, S Muramatsu, Y Ueda, Y Hanazono, K Takeuchi, K Okada, Y Suzuki, Y Kondo, M Suemori, U Ikeda, Nakano, I, E Kobayashi, M Hasegawa, K Ozawa, N Nakatsuji, K Shimada

JOURNAL OF GENE MEDICINE 5(11) 921-928 2003年11月査読有り

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Engraftment and tumor formation after allogeneic in utero transplantation of primate embryonic stem cells.: Takayuki Asano, Naohide Ageyama, Koichi Takeuchi, Mikio Momoeda, Yoshihiro Kitano, Kyoko Sasaki, Yasuji Ueda, Yutaka Suzuki, Yasushi Kondo, Ryuzo Torii, Mamoru Hasegawa, Shigeo Ookawara, Kiyonori Harii, Keiji Terao, Keiya Ozawa, Yutaka Hanazono

Transplantation 76(7) 1061-7 2003年10月15日査読有り

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Collection and analysis of hematopoietic progenitor cells from cynomolgus macaques (Macaca fascicularis): assessment of cross-reacting monoclonal antibodies.: Hiroaki Shibata, Yutaka Hanazono, Naohide Ageyama, Takeyuki Nagashima, Yasuji Ueda, Mamoru Hasegawa, Keiya Ozawa, Yasuhiro Yoshikawa, Keiji Terao

American journal of primatology 61(1) 3-12 2003年9月査読有り

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Reduction of CTLL-2 cytotoxicity by induction of apoptosis with a Fas-estrogen receptor chimera: M Kametaka, A Kum, T Okada, H Mizukami, Y Hanazono, K Ozawa

CANCER SCIENCE 94(7) 639-643 2003年7月査読有り

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Genetic manipulation of primate embryonic and hematopoietic stem cells with simian lentivirus vectors: Y Hanazono, T Asano, Y Ueda, K Ozawa

TRENDS IN CARDIOVASCULAR MEDICINE 13(3) 106-110 2003年4月査読有り

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Distinct patterns of gene transfer to gerbil hippocampus with recombinant adeno-associated virus type 2 and 5: T Nomoto, T Okada, K Shimazaki, H Mizukami, T Matsushita, Y Hanazono, A Kume, K Katsura, Y Katayama, K Ozawa

NEUROSCIENCE LETTERS 340(2) 153-157 2003年4月査読有り

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Distinct patterns of gene transfer to gerbil hippocampus with recombinant adeno-associated virus type 2 and 5: T Nomoto, T Okada, K Shimazaki, H Mizukami, T Matsushita, Y Hanazono, A Kume, K Katsura, Y Katayama, K Ozawa

NEUROSCIENCE LETTERS 340(2) 153-157 2003年4月査読有り

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New selective amplifier genes containing c-Mpl for hematopoietic cell expansion.: Takeyuki Nagashima, Yasuji Ueda, Yutaka Hanazono, Akihiro Kume, Hiroaki Shibata, Naohide Ageyama, Keiji Terao, Keiya Ozawa, Mamoru Hasegawa

Biochemical and biophysical research communications 303(1) 170-6 2003年3月28日査読有り

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New selective amplifier genes containing c-Mpl for hematopoietic cell expansion.: Takeyuki Nagashima, Yasuji Ueda, Yutaka Hanazono, Akihiro Kume, Hiroaki Shibata, Naohide Ageyama, Keiji Terao, Keiya Ozawa, Mamoru Hasegawa

Biochemical and biophysical research communications 303(1) 170-6 2003年3月28日査読有り

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In vivo expansion of transduced murine hematopoietic cells with a selective amplifier gene: A Kume, M Koremoto, RF Xu, T Okada, H Mizukami, Y Hanazono, M Hasegawa, K Ozawa

JOURNAL OF GENE MEDICINE 5(3) 175-181 2003年3月査読有り

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Adeno-associated viral vectors for Parkinson's disease.: Muramatsu S, Wang L, Ikeguchi K, Fujimoto K, Nakano I, Okada T, Mizukami H, Hanazono Y, Kume A, Nakano I, Ozawa K

International review of neurobiology 55 205-222 2003年査読有り

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Intramuscular injection of AAV-GDNF results in sustained expression of transgenic GDNF, and its delivery to spinal motoneurons by retrograde transport: YY Lu, LJ Wang, S Muramatsu, K Ikeguchi, K Fujimoto, T Okada, H Mizukami, T Matsushita, Y Hanazono, A Kume, T Nagatsu, K Ozawa, Nakano, I

NEUROSCIENCE RESEARCH 45(1) 33-40 2003年1月査読有り

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Selective expansion of transduced cells for hematopoietic stem cell gene therapy: A Kume, Y Hanazono, H Mizukami, T Okada, K Ozawa

INTERNATIONAL JOURNAL OF HEMATOLOGY 76(4) 299-304 2002年11月査読有り

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Adeno-associated virus vectors for gene transfer to the brain.: Okada T, Nomoto T, Shimazaki K, Lijun W, Lu Y, Matsushita T, Mizukami H, Urabe M, Hanazono Y, Kume A, Muramatsu S, Nakano I, Ozawa K

Methods (San Diego, Calif.) 28(2) 237-247 2002年10月査読有り

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Introduction of the green ftuorescent protein gene into hematopoietic stem cells results in prolonged discrepancy of in vivo transduction levels between bone marrow progenitors and peripheral blood cells in nonhuman primates: Y Hanazono, K Terao, H Shibata, T Nagashima, N Ageyama, T Asano, Y Ueda, Kato, I, A Kume, M Hasegawa, K Ozawa

JOURNAL OF GENE MEDICINE 4(5) 470-477 2002年9月査読有り

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Highly efficient gene transfer into primate embryonic stem cells with a simian lentivirus vector: T Asano, Y Hanazono, Y Ueda, S Muramatsu, A Kume, H Suemori, Y Suzuki, Y Kondo, K Harii, M Hasegawa, N Nakatsuji, K Ozawa

MOLECULAR THERAPY 6(2) 162-168 2002年8月査読有り

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Adeno-associated viral vector-mediated gene therapy of ischemia-induced neuronal death.: Okada T, Shimazaki K, Nomoto T, Matsushita T, Mizukami H, Urabe M, Hanazono Y, Kume A, Tobita K, Ozawa K, Kawai N

Methods in enzymology 346 378-393 2002年査読有り

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