論文

査読有り 国際誌
2020年3月10日

Intestine-to-Germline Transmission of Epigenetic Information Intergenerationally Ensures Systemic Stress Resistance in C. elegans.

Cell reports
  • Masanori Nono
  • ,
  • Saya Kishimoto
  • ,
  • Aya Sato-Carlton
  • ,
  • Peter Mark Carlton
  • ,
  • Eisuke Nishida
  • ,
  • Masaharu Uno

30
10
開始ページ
3207
終了ページ
3217
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.celrep.2020.02.050

Changes in epigenetic states affect organismal homeostasis, including stress resistance. However, the mechanisms coordinating epigenetic states and systemic stress resistance remain largely unknown. Here, we identify the intestine-to-germline communication of epigenetic states, which intergenerationally enhances stress resistance in C. elegans. The alterations in epigenetic states by deficiency of the histone H3K4me3 modifier ASH-2 in the intestine or germline increase organismal stress resistance, which is abrogated by knockdown of the H3K4 demethylase RBR-2. Remarkably, the increase in stress resistance induced by ASH-2 deficiency in the intestine is abrogated by RBR-2 knockdown in the germline, suggesting the intestine-to-germline transmission of epigenetic information. This communication from intestine to germline in the parental generation increases stress resistance in the next generation. Moreover, the intertissue communication is mediated partly by transcriptional regulation of F08F1.3. These results reveal that intertissue communication of epigenetic information provides mechanisms for intergenerational regulation of systemic stress resistance.

リンク情報
DOI
https://doi.org/10.1016/j.celrep.2020.02.050
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32160530

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