論文

査読有り
2018年2月1日

Phosphorylation of the synaptonemal complex protein SYP-1 promotes meiotic chromosome segregation

Journal of Cell Biology
  • Aya Sato-Carlton
  • ,
  • Chihiro Nakamura-Tabuchi
  • ,
  • Stephane Kazuki Chartrand
  • ,
  • Tomoki Uchino
  • ,
  • Peter Mark Carlton

217
2
開始ページ
555
終了ページ
570
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1083/jcb.201707161
出版者・発行元
Rockefeller University Press

Chromosomes that have undergone crossing over in meiotic prophase must maintain sister chromatid cohesion somewhere along their length between the first and second meiotic divisions. Although many eukaryotes use the centromere as a site to maintain cohesion, the holocentric organism Caenorhabditis elegans instead creates two chromosome domains of unequal length termed the short arm and long arm, which become the first and second site of cohesion loss at meiosis I and II. The mechanisms that confer distinct functions to the short and long arm domains remain poorly understood. Here, we show that phosphorylation of the synaptonemal complex protein SYP-1 is required to create these domains. Once crossover sites are designated, phosphorylated SYP-1 and PLK-2 become cooperatively confined to short arms and guide phosphorylated histone H3 and the chromosomal passenger complex to the site of meiosis I cohesion loss. Our results show that PLK-2 and phosphorylated SYP-1 ensure creation of the short arm subdomain, promoting disjunction of chromosomes in meiosis I.

リンク情報
DOI
https://doi.org/10.1083/jcb.201707161
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29222184

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