Atsuko Deguchi

Profile Information

Affiliation: 東京女子医科大学薬理学教室講師

Degree: 博士（工学）(慶應義塾大学)

J-GLOBAL ID: 201801017237699597

Research Interests

Research History

May, 2020 - Present

Tokyo Women's Medical University
Apr, 2010 - Apr, 2020

Tokyo Women's Medical University
Jul, 2005 - Mar, 2010

Kyoto University Graduate School of Medicine
Oct, 2003 - Jun, 2005

Columbia University
Oct, 1999 - Sep, 2003

Columbia University

Education

Apr, 1996 - Sep, 1999

Keio University

Papers

Lung Tumor Cell Recruitment Assay.

Tomita T, Ieguchi K, Deguchi A, Takita M, Tsukahara F, Hiratsuka S, Maru Y

Journal of visualized experiments : JoVE (144) Feb, 2019 Peer-reviewed
Dickkopf-1 helps metastasis by immune evasion

Deguchi A, Maru Y

Transl Cancer Res. 6 S1422 - S1424 Oct, 2017 Peer-reviewed
Histone deacetylase inhibitor panobinostat induces calcineurin degradation in multiple myeloma.

Yoichi Imai, Eri Ohta, Shu Takeda, Satoko Sunamura, Mariko Ishibashi, Hideto Tamura, Yan-Hua Wang, Atsuko Deguchi, Junji Tanaka, Yoshiro Maru, Toshiko Motoji

JCI insight 1(5) e85061 Apr 21, 2016 Peer-reviewed
Eritoran inhibits S100A8-mediated TLR4/MD-2 activation and tumor growth by changing the immune microenvironment

A. Deguchi, T. Tomita, U. Ohto, K. Takemura, A. Kitao, S. Akashi-Takamura, K. Miyake, Y. Maru

ONCOGENE 35(11) 1445 - 1456 Mar, 2016 Peer-reviewed
Curcumin Targets in Inflammation and Cancer

Atsuko Deguchi

ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS 15(2) 88 - 96 2015 Peer-reviewed
Drug Targeting Based on a New Concept-Targeting Against TLR4 as an Example

Yoshiro Maru, Takeshi Tomita, Atsuko Deguchi, Katsuaki Ieguchi, Morichika Takita, Fujiko Tsukahara, Kazuhiro Takemura, Akio Kitao, Fabian Gusovsky

ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS 15(2) 83 - 87 2015 Peer-reviewed
ADAM12-cleaved ephrin-A1 contributes to lung metastasis

K. Ieguchi, T. Tomita, T. Omori, A. Komatsu, A. Deguchi, J. Masuda, S. L. Duffy, M. G. Coulthard, A. Boyd, Y. Maru

ONCOGENE 33(17) 2179 - 2190 Apr, 2014 Peer-reviewed
Ephrin-A1 expression induced by S100A8 is mediated by the toll-like receptor 4

Katsuaki Ieguchi, Tsutomu Omori, Akiko Komatsu, Takeshi Tomita, Atsuko Deguchi, Yoshiro Maru

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 440(4) 623 - 629 Nov, 2013 Peer-reviewed
Serum amyloid A3 binds MD-2 to activate p38 and NF-κB pathways in a MyD88-dependent manner

Atsuko Deguchi, Takeshi Tomita, Tsutomu Omori, Akiko Komatsu, Umeharu Ohto, Satoshi Takahashi, Natsuko Tanimura, Sachiko Akashi-Takamura, Kensuke Miyake, Yoshiro Maru

Journal of Immunology 191(4) 1856 - 1864 Aug 15, 2013 Peer-reviewed
LKB1 Suppresses p21-activated Kinase-1 (PAK1) by Phosphorylation of Thr(109) in the p21-binding Domain

Atsuko Deguchi, Hiroyuki Miyoshi, Yasushi Kojima, Katsuya Okawa, Masahiro Aoki, Makoto M. Taketo

JOURNAL OF BIOLOGICAL CHEMISTRY 285(24) 18283 - 18290 Jun, 2010 Peer-reviewed
Hepatocellular carcinoma development induced by conditional beta-catenin activation in Lkb1+/- mice

Hiroyuki Miyoshi, Atsuko Deguchi, Masayuki Nakau, Yasushi Kojima, Akira Mori, Masanobu Oshima, Masahiro Aoki, Makoto Mark Taketo

CANCER SCIENCE 100(11) 2046 - 2053 Nov, 2009 Peer-reviewed
Activation of protein kinase G increases the expression of p21(CIP1), p27(KIP1), and Histidine triad protein 1 through Sp1

Bo Cen, Atsuko Deguchi, I. Bernard Weinstein

CANCER RESEARCH 68(13) 5355 - 5362 Jul, 2008 Peer-reviewed
Dip1 inhibits growth and gene transcription in MCF-7 breast cancer cells.

Su T, Deguchi A, Yao Y, Luo J, Weinstein IB

Journal of experimental therapeutics & oncology 6(2) 117 - 127 2007 Peer-reviewed
The sulindac derivatives OSI-461, OSIP486823, and OSIP487703 arrest colon cancer cells in mitosis by causing microtubule depolymerization

D Xiao, A Deguchi, GG Gundersen, B Oehlen, L Arnold, IB Weinstein

MOLECULAR CANCER THERAPEUTICS 5(1) 60 - 67 Jan, 2006 Peer-reviewed
EGCG inhibits activation of the insulin-like growth factor-1 receptor in human colon cancer cells

M Shimizu, A Deguchi, Y Hara, H Moriwaki, IB Weinstein

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 334(3) 947 - 953 Sep, 2005 Peer-reviewed
Activation of protein kinase G up-regulates expression of 15-lipoxygenase-1 in human colon cancer cells

A Deguchi, SW Xing, Shureiqi, I, PY Yang, RA Newman, SM Lippman, SJ Feinmark, B Oehlen, IB Weinstein

CANCER RESEARCH 65(18) 8442 - 8447 Sep, 2005 Peer-reviewed
(-)-epigallocatechin gallate and polyphenon E inhibit growth and activation of the epidermal growth factor receptor and human epidermal growth factor receptor-2 signaling pathways in human colon cancer cells

M Shimizu, A Deguchi, JTE Lim, H Moriwaki, L Kopelovich, IB Weinstein

CLINICAL CANCER RESEARCH 11(7) 2735 - 2746 Apr, 2005 Peer-reviewed
EGCG inhibits activation of HER3 and expression of cyclooxygenase-2 in human colon cancer cells

Masahito Shimizu, Atsuko Deguchi, Andrew K. Joe, Judith F. Mckoy, Hisataka Moriwaki, I. Bernard Weinstein

Journal of Experimental Therapeutics and Oncology 5(1) 69 - 78 2005 Peer-reviewed
Synergistic effects of acyclic retinoid and OSI-461 on growth inhibition and gene expression in human hepatoma cells

M Shimizu, M Suzui, A Deguchi, JTE Lim, DH Xiao, JH Hayes, KP Papadopous, IB Weinstein

CLINICAL CANCER RESEARCH 10(19) 6710 - 6721 Oct, 2004 Peer-reviewed
Activation of protein kinase G is sufficient to induce apoptosis and inhibit cell migration in colon cancer cells

A Deguchi, WJ Thompson, IB Weinstein

CANCER RESEARCH 64(11) 3966 - 3973 Jun, 2004 Peer-reviewed
Effects of acyclic retinoid on growth, cell cycle control, epidermal growth factor receptor signaling, and gene expression in human squamous cell carcinoma cells

M Shimizu, M Suzui, A Deguchi, JTE Lim, IB Weinstein

CLINICAL CANCER RESEARCH 10(3) 1130 - 1140 Feb, 2004 Peer-reviewed
Induction of apoptosis by the garlic-derived compound S-allylmercaptocysteine (SAMC) is associated with microtubule depolymerization and c-Jun NH2-terminal kinase 1 activation

DH Xiao, JT Pinto, JW Soh, A Deguchi, GG Gundersen, AF Palazzo, JT Yoon, H Shirin, IB Weinstein

CANCER RESEARCH 63(20) 6825 - 6837 Oct, 2003 Peer-reviewed
Epigallocatechin-3-gallate decreases VEGF production in head and neck and breast carcinoma cells by inhibiting EGFR-related pathways of signal transduction.

Masuda M, Suzui M, Lim JT, Deguchi A, Soh JW, Weinstein IB

Journal of experimental therapeutics & oncology 2(6) 350 - 359 Nov, 2002 Peer-reviewed
Vasodilator-stimulated phosphoprotein (VASP) phosphorylation provides a biomarker for the action of exisulind and related agents that activate protein kinase G

A Deguchi, JW Soh, H Li, R Pamukcu, WJ Thompson, IB Weinstein

MOLECULAR CANCER THERAPEUTICS 1(10) 803 - 809 Aug, 2002 Peer-reviewed
The roles of JNK1 and Stat3 in the response of head and neck cancer cell lines to combined treatment with all-trans-retinoic acid and 5-fluorouracil

M Masuda, S Toh, K Koike, Y Kuratomi, M Suzui, A Deguchi, S Komiyama, IB Weinstein

JAPANESE JOURNAL OF CANCER RESEARCH 93(3) 329 - 339 Mar, 2002 Peer-reviewed
Overexpression of phosphatidylinositol synthase enhances growth and G1 progression in NIH3T3 cells

A Deguchi, K Segawa, K Hosaka, IB Weinstein, K Umezawa

JAPANESE JOURNAL OF CANCER RESEARCH 93(2) 157 - 166 Feb, 2002 Peer-reviewed
Induction of G1 arrest and selective growth inhibition by lactacystin in human umbilical vein endothelial cells

SI Kumeda, A Deguchi, M Toi, S Omura, K Umezawa

ANTICANCER RESEARCH 19(5B) 3961 - 3968 Sep, 1999 Peer-reviewed
イノシトール代謝回転阻害剤と細胞周期の制御

梅沢一夫, 出口敦子, 井本正哉

癌と化学療法、 (24) Sep, 1997
Screening of phosphatidylinositol turnover inhibitors and regulation of cell cycle progression

K. Umezawa, A. Deguchi, M. Imoto

Japanese Journal of Cancer and Chemotherapy 24(11) 1578 - 1584 1997 Peer-reviewed
Inhibition of G1 cyclin expression in normal rat kidney cells by inostamycin, a phosphatidylinositol synthesis inhibitor

A Deguchi, M Imoto, K Umezawa

JOURNAL OF BIOCHEMISTRY 120(6) 1118 - 1122 Dec, 1996 Peer-reviewed
In situ inhibition of protein-tyrosine phosphatase by dephostatin.

井本正哉, 出口敦子, 早川哲, 梅沢一夫

Cell. Pharmacol. (2) Feb, 1995
INVOLVEMENT OF PHOSPHATIDYLINOSITOL SYNTHESIS IN THE REGULATION OF S-PHASE INDUCTION

M IMOTO, T MORII, A DEGUCHI, K UMEZAWA

EXPERIMENTAL CELL RESEARCH 215(1) 228 - 233 Nov, 1994 Peer-reviewed

Misc.

自然免疫系による疾患の誘導と制御がん転移と自然免疫

出口敦子, 丸義朗

医学のあゆみ 265(13) 1271‐1275 Jun 30, 2018
マウスの肺組織内における神経網の観察

家口勝昭, 平塚佐千枝, 富田毅, 出口敦子, 瀧田守親, 三島大志, 丸義朗

東京女子医科大学総合研究所紀要 37 42‐43 Mar 31, 2018
がん細胞の特質に依存した転移前ニッチ形成の分子機序

出口敦子, 三島大志, 丸義朗

東京女子医科大学総合研究所紀要 37 44‐45 Mar 31, 2018
転移前ニッチ形成に関与する骨髄由来免疫抑制細胞の役割

出口敦子, 三島大志, 丸義朗

東京女子医科大学総合研究所紀要 36 33 Feb 27, 2017
Toll様受容体内因性リガンドによるがん微小環境形成に伴う胃がん増悪化

出口敦子, 丸義朗, 大島正伸, 大島浩子

金沢大学がん進展制御研究所がんの転移・薬剤耐性に関わる先導的研究拠点 2016 147 2017
Toll様受容体内因性リガンドによるがん微小環境の増悪化

出口敦子, 丸義朗, 大島正伸, 大島浩子

金沢大学がん進展制御研究所がんの転移・薬剤耐性に関わる先導的研究拠点 2015 83 2016
がんにおける血管・リンパ管新生 8.がんの転移前ニッチ

出口敦子, 丸義朗

実験医学 33(5) 815 - 819 Mar 15, 2015
原発巣におけるephrin‐A1の発現調節機構

家口勝昭, 富田毅, 出口敦子, 平塚佐千枝, 丸義朗

東京女子医科大学総合研究所紀要 34 28-29,152 Nov 30, 2014
肺におけるEph/ephrinシステムの機能解析

家口勝昭, 富田毅, 出口敦子, 平塚佐千枝, 丸義朗

東京女子医科大学総合研究所紀要 33 32-33,157 Nov 30, 2013
細胞接着におけるEphA1受容体の機能解析

家口勝昭, 富田毅, 出口敦子, 平塚佐千枝, 丸義朗

東京女子医科大学総合研究所紀要 32 36 - 37 2012
Sulindac derivatives can activate apoptosis by Cox-independent mechanisms.

IB Weinstein, JW Soh, A Deguchi, JTE Lim

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION 11(10) 1243S - 1243S Oct, 2002

Presentations

転移前ニッチ形成を標的とした新規がん治療への展開

出口敦子

東京女子医科大学学会 Feb 24, 2018
大腸癌肝転移に伴う転移前肝微小環境の形成

出口敦子

東京女子医科大学雑誌 Feb 25, 2014

Professional Memberships

Research Projects

転移前肝微小環境形成因子による臓器決定性と腫瘍クロストーク

日本学術振興会科学研究費補助金基盤研究(C)

出口敦子
転移前肝ニッチ形成因子による肝転移促進の分子機序

公益財団法人アステラス病態代謝研究会
転移前肝微小環境形成による転移促進の分子機序

日本学術振興会科学研究費補助金基盤研究(C)

出口敦子
Toll様受容体を介した肝特異的転移前微小環境の構築

日本学術振興会科学研究費補助金基盤研究(C)

出口敦子
TLR4内因性リガンドS100A8によるがん微小環境のフィードバック活性化

公益財団法人武田科学振興財団医学系研究奨励

出口敦子
LKB1欠失による肝癌発症の分子機序の解析

日本学術振興会科学研究費補助金若手研究(B)

出口敦子

Profile Information

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Research History

Education

Papers

Misc.

Presentations

Professional Memberships

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