論文

査読有り
2013年11月

Ephrin-A1 expression induced by S100A8 is mediated by the toll-like receptor 4

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
  • Katsuaki Ieguchi
  • ,
  • Tsutomu Omori
  • ,
  • Akiko Komatsu
  • ,
  • Takeshi Tomita
  • ,
  • Atsuko Deguchi
  • ,
  • Yoshiro Maru

440
4
開始ページ
623
終了ページ
629
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.bbrc.2013.09.119
出版者・発行元
ACADEMIC PRESS INC ELSEVIER SCIENCE

The deregulation of Eph/ephrin protein expression has been shown to lead to tumor development and progression. Both mRNA and protein expression analyses using clinical samples have demonstrated that ephrin-A1 is over-expressed in various cancers and positively correlates with a poor prognosis for cancer patients. The prognosis of cancer patients depends on metastasis to distant organs. We previously demonstrated that ADAM12 metalloproteinase cleaved ephrin-A1 and ADAM12-cleaved ephrin-A1 enhanced vascular permeability by degrading VE-cadherin and the EphA2 receptor at the plasma membrane. An increase of soluble ephrin-A1 levels in the serum facilitated tumor cell recruitment to the lungs, which resulted in lung metastasis. We also found that ephrin-A1 was overexpressed in 3LL tumors, a highly metastatic tumor, in mice and TNF alpha, an authentic positive regulator of ephrin-A1, was not elevated in the tumors, whereas S100A8 was. Moreover, S100A8 induced ephrin-A1 expression mediated by the toll-like receptor 4 (TLR4). S100A8 is known to be an endogenous ligand for TLR4 and its expression was shown to be increased in the lungs at the premetastatic phase. Thus, S100A8 and ephrin-A1 contribute to lung metastasis. Therefore, elucidating the regulation mechanism of ephrin-A1 overexpression is of importance and may lead to the development of therapeutic drugs against tumor growth and metastasis. (C) 2013 Elsevier Inc. All rights reserved.

Web of Science ® 被引用回数 : 11

リンク情報
DOI
https://doi.org/10.1016/j.bbrc.2013.09.119
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/24103748
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000326905800029&DestApp=WOS_CPL
URL
http://europepmc.org/abstract/med/24103748
URL
http://orcid.org/0000-0001-6815-2244

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