論文

査読有り
2006年1月

The sulindac derivatives OSI-461, OSIP486823, and OSIP487703 arrest colon cancer cells in mitosis by causing microtubule depolymerization

MOLECULAR CANCER THERAPEUTICS
  • D Xiao
  • ,
  • A Deguchi
  • ,
  • GG Gundersen
  • ,
  • B Oehlen
  • ,
  • L Arnold
  • ,
  • IB Weinstein

5
1
開始ページ
60
終了ページ
67
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1158/1535-7163.MCT-05-0260
出版者・発行元
AMER ASSOC CANCER RESEARCH

Exisulind (sulindac sulfone) and three highly potent derivatives, OSI-461 (CP461), OSIP486823 (CP248), and OSIP487703, inhibit growth and induce apoptosis in SW480 human colon cancer cells, with IC(50)s of 200, 2, 0.1, and 0.003 mu mol/L, respectively. The latter three compounds, but not exisulind, induce marked M-phase cell cycle arrest in these cells. This effect seems to be independent of the known ability of these compounds to cause activation of protein kinase G. When tested at twice their IC50 concentration for growth inhibition, CSI-461, OSIP486823, and OSIP487703 cause depolymerization of microtubules in interphase cells, inhibit spindle formation in mitotic cells, and induce multinucleated cells. In vitro tubulin polymerization assays indicate that all three compounds interact with tubulin directly to cause microtubule depolymerization and/or inhibit de novo tubulin polymerization. These results suggest that the dual effects of OSI-461, OSIP486823, and OSIP487703 on impairment of microtubule functions and protein kinase G activation may explain the potent antiproliferative and apoptotic effects of these compounds in cancer cells.

Web of Science ® 被引用回数 : 20

リンク情報
DOI
https://doi.org/10.1158/1535-7163.MCT-05-0260
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000234772900007&DestApp=WOS_CPL

エクスポート
BibTeX RIS