論文

査読有り
2015年

Curcumin Targets in Inflammation and Cancer

ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
  • Atsuko Deguchi

15
2
開始ページ
88
終了ページ
96
記述言語
英語
掲載種別
研究論文(学術雑誌)
出版者・発行元
BENTHAM SCIENCE PUBL LTD

Curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) is commonly used as a spice, food additive or dietary pigment. Accumulating evidence suggests that curcumin has several pharmacologic effects, including anti-inflammatory, anti-oxidant and anti-cancer activities. The molecular mechanisms underlying the targets of curcumin are diverse and involve combinations of multiple signaling pathways, including NF-kappa B and STAT3 signaling. Thus, curcumin is one of the most promising phytochemicals that target various cancers and inflammation-mediated diseases. Clinical trials have been ongoing or completed for various cancers, including breast, pancreatic and colorectal cancers, and multiple myeloma. In this review, the molecular mechanisms and the issue of bioavailability are mainly discussed.

Web of Science ® 被引用回数 : 54

リンク情報
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/25772169
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000355000200003&DestApp=WOS_CPL

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