HOSHINO ATSUSHI

Profile Information

Affiliation: Kyoto Prefectural University of Medicine

Degree: 医学博士(京都府立医科大学)

Researcher number: 50737210
J-GLOBAL ID: 201801008313377635
researchmap Member ID: B000316527

Research Interests

Research Areas

Life sciences / Cardiology /

Research History

Apr, 2022 - Present

講師, 京都府立医科大学循環器内科
Jul, 2019 - Mar, 2022

Kyoto Prefectural University of Medicine
Sep, 2017 - Jun, 2019

Assistant professor, Cardiovasular medicine, Kyoto Prefectural University of Medicine
Aug, 2015 - Jul, 2017

Postdoctoral Fellow for Research Abroad, Japan Society for the Promotion of Science
Aug, 2014 - Jul, 2017

Postdoc fellow, Cardiovasular institute, University of Pennsylvania
Apr, 2014 - Jul, 2014

Postdoc fellow, Cardiovasular medicine, Kyoto Prefectural University of Medicine
Apr, 2011 - Mar, 2014

Research fellow, Cardiovasular medicine, Kyoto Prefectural University of Medicine
Apr, 2005 - Mar, 2007

Senior resident, internal medicine, Saiseikai Shiga Hospital
Jun, 2004 - Mar, 2005

Junior resident, Cardiology, Kyoto second red cross hospital
Apr, 2003 - Jun, 2004

Junior resident, internal medicine, Kyoto Prefectural University of Medicine Hospital

Education

Apr, 2007 - Mar, 2011

Kyoto Prefectural University of Medicine
Apr, 1997 - Mar, 2003

Kyoto Prefectural University of Medicine

Awards

Oct, 2020

永井賞, 第56回高血圧関連疾患モデル学会学術総会
Jun, 2019

Richard J Bing Award for Young Investigators, ISHR

HOSHINO ATSUSHI
Sep, 2018

Basic research grant, Japanese Circulation Society

HOSHINO ATSUSHI
2015

Postdoctoral Fellow for Research Abroad, Japan Society for the Promotion of Science

HOSHINO ATSUSHI
2014

Postdoctoral Fellowship, The Uehara Memorial Foundation

HOSHINO ATSUSHI
2013

Shoren award, Kyoto Prefectural University of Medicine

HOSHINO ATSUSHI
2012

poster award, 3rd Molecular Cardiovascular Conference II

HOSHINO ATSUSHI

Major Papers

An AsCas12f-based compact genome-editing tool derived by deep mutational scanning and structural analysis.

Tomohiro Hino, Satoshi N Omura, Ryoya Nakagawa, Tomoki Togashi, Satoru N Takeda, Takafumi Hiramoto, Satoshi Tasaka, Hisato Hirano, Takeshi Tokuyama, Hideki Uosaki …

Cell, 186(22) 4920-4935, Sep 22, 2023 Corresponding author
An inhaled ACE2 decoy confers protection against SARS-CoV-2 infection in preclinical models.

Emiko Urano, Yumi Itoh, Tatsuya Suzuki, Takanori Sasaki, Jun-Ichi Kishikawa, Kanako Akamatsu, Yusuke Higuchi, Yusuke Sakai, Tomotaka Okamura, Shuya Mitoma …

Science translational medicine, 15(711) eadi2623, Aug 30, 2023 Corresponding author
Structural delineation and computational design of SARS-CoV-2-neutralizing antibodies against Omicron subvariants.

Saya Moriyama, Yuki Anraku, Shunta Taminishi, Yu Adachi, Daisuke Kuroda, Shunsuke Kita, Yusuke Higuchi, Yuhei Kirita, Ryutaro Kotaki, Keisuke Tonouchi …

Nature communications, 14(1) 4198-4198, Jul 14, 2023
Liver lipophagy ameliorates nonalcoholic steatohepatitis through extracellular lipid secretion.

Yoshito Minami, Atsushi Hoshino, Yusuke Higuchi, Masahide Hamaguchi, Yusaku Kaneko, Yuhei Kirita, Shunta Taminishi, Toshiyuki Nishiji, Akiyuki Taruno, Michiaki Fukui …

Nature communications, 14(1) 4084-4084, Jul 13, 2023 Lead authorCorresponding author
Deep Mutational Scanning to Predict Escape from Bebtelovimab in SARS-CoV-2 Omicron Subvariants.

Mellissa C Alcantara, Yusuke Higuchi, Yuhei Kirita, Satoaki Matoba, Atsushi Hoshino

Vaccines, 11(3), Mar 22, 2023 Last authorCorresponding author
Engineering ACE2 decoy receptors to combat viral escapability

Takao Arimori, Nariko Ikemura, Toru Okamoto, Junichi Takagi, Daron M. Standley, Atsushi Hoshino

Trends in Pharmacological Sciences, Jul, 2022 InvitedLast authorCorresponding author
An engineered ACE2 decoy neutralizes the SARS-CoV-2 Omicron variant and confers protection against infection in vivo

Nariko Ikemura, Shunta Taminishi, Tohru Inaba, Takao Arimori, Daisuke Motooka, Kazutaka Katoh, Yuhei Kirita, Yusuke Higuchi, Songling Li, Tatsuya Suzuki …

Science Translational Medicine, 14(650) eabn7737, Apr 26, 2022 Last authorCorresponding author
Engineered ACE2 receptor therapy overcomes mutational escape of SARS-CoV-2.

Yusuke Higuchi, Tatsuya Suzuki, Takao Arimori, Nariko Ikemura, Emiko Mihara, Yuhei Kirita, Eriko Ohgitani, Osam Mazda, Daisuke Motooka, Shota Nakamura …

Nature communications, 12(1) 3802-3802, Jun 21, 2021 Last authorCorresponding author
The ADP/ATP translocase drives mitophagy independent of nucleotide exchange.

Hoshino A, Wang WJ, Wada S, McDermott-Roe C, Evans CS, Gosis B, Morley MP, Rathi KS, Li J, Li K …

Nature, 575(7782) 375-379, Nov, 2019 Lead author
NADPH production by the oxidative pentose-phosphate pathway supports folate metabolism.

Chen L, Zhang Z, Hoshino A, Zheng HD, Morley M, Arany Z, Rabinowitz JD

Nature metabolism, 1 404-415, Mar, 2019
Observation of Parkin-Mediated Mitophagy in Pancreatic β-Cells.

Hoshino A, Matoba S

Methods in molecular biology (Clifton, N.J.), 1759 41-46, 2018 Peer-reviewedInvitedLead author
Oxidative Post-Translational Modifications Develop LONP1 Dysfunction in Pressure Overload Heart Failure

Atsushi Hoshino, Yoshifumi Okawa, Makoto Ariyoshi, Satoshi Kaimoto, Motoki Uchihashi, Kuniyoshi Fukai, Eri Iwai-Kanai, Satoaki Matoba

CIRCULATION-HEART FAILURE, 7(3) 500-U224, May, 2014 Lead author
Inhibition of p53 preserves Parkin-mediated mitophagy and pancreatic beta-cell function in diabetes

Atsushi Hoshino, Makoto Ariyoshi, Yoshifumi Okawa, Satoshi Kaimoto, Motoki Uchihashi, Kuniyoshi Fukai, Eri Iwai-Kanai, Koji Ikeda, Tomomi Ueyama, Takehiro Ogata …

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 111(8) 3116-3121, Feb, 2014 Lead author
Cytosolic p53 inhibits Parkin-mediated mitophagy and promotes mitochondrial dysfunction in the mouse heart

Atsushi Hoshino, Yuichiro Mita, Yoshifumi Okawa, Makoto Ariyoshi, Eri Iwai-Kanai, Tomomi Ueyama, Koji Ikeda, Takehiro Ogata, Satoaki Matoba

NATURE COMMUNICATIONS, 4 2308, Aug, 2013 Peer-reviewedLead author

Misc.

Age Related Cardiac Dysfunction and Pancreatic beta-cell Function in Diabetes Were Improved by P53 Inhibition Through Parkin-mediated Mitophagy

Makoto Ariyoshi, Atsushi Hoshino, Yoshifumi Okawa, Syuhei Tateishi, Daichi Hato, Ryoetsu Yamanaka, Sakiko Honda, Yohei Fushimura, Eri Iwai-Kanai, Satoaki Matoba

CIRCULATION, 134, Nov, 2016
Age Related Cardiac Dysfunction and Pancreatic beta-cell Function in Diabetes Were Improved by P53 Inhibition Through Parkin-mediated Mitophagy

Makoto Ariyoshi, Atsushi Hoshino, Yoshifumi Okawa, Syuhei Tateishi, Daichi Hato, Ryoetsu Yamanaka, Sakiko Honda, Yohei Fushimura, Eri Iwai-Kanai, Satoaki Matoba

CIRCULATION, 134, Nov, 2016
Activation of PPAR alpha During the Progressive Phase of Heart Failure Improved Myocardial Energetics and Function in Pressure Overload Heart Failure

Satoshi Kaimoto, Atsushi Hoshino, Makoto Ariyoshi, Yoshifumi Okawa, Motoki Uchihashi, Kuniyoshi Fukai, Kazunori Ono, Shuhei Tateishi, Eri Iwai-Kanai, Satoaki Matoba

CIRCULATION, 130, Nov, 2014
Activation of PPAR Alpha during Heart Failure Maintained Myocardial Function and Energetics in Mice Transverse Aortic Constriction (TAC) Model

Satoshi Kaimoto, Atsushi Hoshino, Yoshifumi Okawa, Makoto Ariyoshi, Kuniyoshi Fukai, Motoki Uchihashi, Kazunori Ono, Shuhei Tateishi, Eri Iwai-Kanai, Satoaki Matoba

JOURNAL OF CARDIAC FAILURE, 20(10) S189-S189, Oct, 2014
Ketone Body Metabolism Attenuates Oxidative Stress and Cardiac Remodeling in Pressure Overload Heart Failure

Motoki Uchihashi, Atsushi Hoshino, Makoto Ariyoshi, Shuhei Tateishi, Kazunori Ono, Satoshi Kaimoto, Kuniyoshi Fukai, Eri Kanai, Satoaki Matoba

JOURNAL OF CARDIAC FAILURE, 20(10) S204-S204, Oct, 2014
Cardiac-specific Overexpression of Bdh1 Ameliorates Oxidative Stress and Cardiac Remodeling in Pressure Overload Heart Failure

Motoki Uchihashi, Atsushi Hoshino, Yoshifumi Okawa, Makoto Ariyoshi, Satoshi Kaimoto, Kuniyoshi Fukai, Eri I. Kanai, Satoaki Matoba

CIRCULATION, 128(22), Nov, 2013
Tigar (tp53-induced Glycolysis And Apoptosis Regulator) Decreases Glycogenic Energy Metabolism and Deteriorates Left Ventricular Function in Pressure Overload-induced Heart Failure Model

Yoshifumi Okawa, Eri Iwai-Kanai, Yuichiro Mita, Atsushi Hoshino, Maki Katamura, Makoto Ariyoshi, Satoshi Kaimoto, Kuniyoshi Fukai, Motoki Uchihashi, Satoaki Matoba

CIRCULATION, 128(22), Nov, 2013
Inhibition of Oxidative Modification in Mitochondrial Proteases Ameliorates Declines of Mitochondrial Respiration and Cardiac Contractility in Pressure Overload Heart Failure

Satoshi Kaimoto, Atsushi Hoshino, Yoshifumi Okawa, Makoto Ariyoshi, Motoki Uchihashi, Kuniyoshi Fukai, Eri Iwai-Kanai, Satoaki Matoba

CIRCULATION, 128(22), Nov, 2013
Inhibition of Protease Oxidation Preserves Protein Turnover of Mitochondrial Electron Transport Complex and Improves Respiration Capacity in Pressure Overload Heart

Atsushi Hoshino, Satoaki Matoba, Yuichiro Mita, Eri Iwai-Kanai, Hiroaki Matsubara

CIRCULATION, 126(21), Nov, 2012
Inhibition of Cytosolic p53 Preserves Mitochondrial Integrity and Prevents Cardiac Aging

Atsushi Hoshino, Satoaki Matoba, Maki Katamura, Yoshifumi Okawa, Makoto Ariyoshi, Satoshi Kaimoto, Yuichiro Mita, Hiroaki Matsubara

CIRCULATION, 126(21), Nov, 2012
Curcumin Prevents Doxorubicin-Induced Cardiotoxicity Through Phosphorylated Bcl-2-Regulated Autophagy

Maki Katamura, Satoaki Matoba, Eri Iwi-Kanai, Atsushi Hoshino, Yoshifumi Okawa, Yuichiro Mita, Makoto Ariyoshi, Satoshi Kaimoto, Hiroaki Matsubara

CIRCULATION, 126(21), Nov, 2012
p53-Tigar Axis Attenuates Mitophagy Tt Exacerbate Cardiac Damage After Ischemia

Atsushi Hoshino, Satoaki Matoba, Eri Iwai-Kanai, Maki Katamura, Yoshifumi Okawa, Makoto Ariyoshi, Yuichiro Mita, Hiroaki Matsubara

CIRCULATION, 124(21), Nov, 2011
p53 Promotes Cardiac Dysfunction in Diabetes Mellitus by Excessive Mitochondrial Respiration and Fat/cd36 Upregulation

Hideo Nakamura, Satoaki Matoba, Eri Iwai-Kanai, Masaki Kimata, Atsushi Hoshino, Mikihiko Nakaoka, Maki Katamura, Yoshihumi Okawa, Yuichiro Mita, Makoto Ariyoshi …

CIRCULATION, 124(21), Nov, 2011
p53 Promotes Cardiac Aging Through The Inhibition Of Parkin Mediated Mitochondrial Quality Control

Atsushi Hoshino, Satoaki Matoba, Eri Iwai-Kanai, Maki Katamura, Yoshifumi Okawa, Makoto Ariyoshi, Yuichiro Mita, Hiroaki Matsubara

CIRCULATION, 124(21), Nov, 2011
Mediated Decrease in ROS Signal Reduces Mitophagy via Inactivation of Bnip3 to Aggravate Cardiac Damage After Ischemic Injury

Atsushi Hoshino, Satoaki Matoba, Eri Iwai-Kanai, Masaki Kimata, Hideo Nakamura, Mikihiko Nakaoka, Yoshifumi Okawa, Maki Katamura, Hiroaki Matsubara

CIRCULATION, 122(21), Nov, 2010
p53-mediated Acceleration of Mitochondrial Oxygen Consumption Promotes Lipotoxicity via SCO2 in Diabetic Mice

Hideo Nakamura, Satoaki Matoba, Eri Iwai-Kanai, Masaki Kimata, Atsushi Hoshino, Mikihiko Nakaoka, Maki Katamura, Yoshifumi Okawa, Yuichiro Mita, Tetsuya Tatsumi …

CIRCULATION, 122(21), Nov, 2010
p53 Promotes Heart Failure With Lipid Accumulation in Diabetes

Hideo Nakamura, Satoaki Matoba, Eri Iwi-Kanai, Masaki Kimata, Atsushi Hoshino, Mikihiko Nakaoka, Maki Katamura, Tetsuya Tatsumi, Hiroaki Matsubara

CIRCULATION, 120(18) S895-S895, Nov, 2009
Differential Roles of Akt and Extracellular Signal-Regulated Kinase Signaling Pathways on Autophagy During Alpha1-Adrenergic Agonist-Mediated Cardioprotection

Mikihiko Nakaoka, Eri Iwai-Kanai, Satoaki Matoba, Masaki Kimata, Hideo Nakamura, Atsushi Hoshino, Maki Katamura, Yoshimi Hiraumi, Hiroaki Matsubara

CIRCULATION, 120(18) S902-S902, Nov, 2009
38) SATによるAMI第2病日に冠動脈スパズムによる心停止を来たした一例(第105回日本循環器学会近畿地方会)

矢西賢次, 西澤信也, 榎本聖子, 小出正洋, 星野温, 畔柳彰, 中村猛, 松室明義, 沢田尚久, 松原弘明

Circulation journal : official journal of the Japanese Circulation Society, 72 1095-1095, Oct 20, 2008
p53 Is a New Target to Improve Cardiac Metabolism

Masaki Kimata, Satoaki Matoba, Hideo Nakamura, Atsushi Hoshino, Mikihiko Nakaoka, Yoshimi Hiraumi, Eri Kanai-Iwai, Tetsuya Tatsumi, Hiroaki Matsubara

CIRCULATION RESEARCH, 103(5) E50-E50, Aug, 2008

Books and Other Publications

ミトコンドリアダイナミクス : 機能研究から疾患・老化まで

星野温 (Role: Contributor, 第3章3節ミトコンドリアの質を管理するマイトファジーメカニズム)

エヌ・ティー・エス, Oct, 2021 (ISBN: 9784860437466)
創薬研究者がこれだけは知っておきたい最新のウイルス学

星野温 (Role: Contributor, 第10章第10節ウイルスと強力に結合して重症化を防ぐタンパク質（ACE2))

技術情報協会, Aug, 2021 (ISBN: 9784861048555)
新しい臨床を開拓するための分子循環器病学

星野温、的場聖明 (Role: Joint author, 11章ミトコンドリア異常は心不全の原因か)

南山堂, 2019 (ISBN: 9784525249410)
Aging-related changes in mitochondrial function and implication for heart failure therapy. Aging and Heart Failure: Mechanisms & Management edited by Bodh I. Jugdutt

Matoba S, Hoshino A, Matsubara H (Role: Joint author)

2014

Presentations

Defects in Mitophagy Drive the Pathophysiology of ANT1-associated Myopathy.

星野温

第87回日本循環器学会総会, Mar 11, 2023 Invited
Liver lipophagy activates lysosomal exocytosis and ameliorates Non-alcoholic steatohepatitis.

星野温

第87回日本循環器学会総会, Mar 11, 2023 Invited
18. 線維化セクレトーム制御転写ネットワークの解明

星野温

第70 回日本心臓病学会学術集会, Sep 25, 2022 Invited
オートファジーによるミトコンドリア品質管理と創薬応用

星野温

第31回日本循環薬理学会, Dec 3, 2021 Invited
高親和性ACE2によるウイルス逃避変異抵抗性COVID-19治療薬の開発

星野温

第94回日本生化学学会大会, Nov 3, 2021 Invited
Engineering high affinity ACE2 with human cell-based directed evolution.

Atsushi Hoshino

JCS 2021, Mar 27, 2021
Mitochondrial biogenesis coupled with mitophagy-mediated mitochondrial degradation.

Atsushi Hoshino

Mar 13, 2021
選択的オートファジー～mitophagy and beyond～

星野温

第 23回小児心血管分子医学研究会, Nov 22, 2020 Invited
The mitochondrial adenine nucleotide translocator mediates Parkin-mediated mitophagy

Atsushi Hoshino

ISHR Asia-Pacific Cardiovascular Webinar Series, Jul 8, 2020 Invited
The mitochondrial adenine nucleotide translocator mediates mitophagy independently of its nucleotide exchange activity.

Atsushi Hoshino

JSC 2020, Jul, 2020
マイトファジーによる心筋ミトコンドリア機能制御

星野温

第３回基礎循環器サイエンスにおける若手研究者イニシアチブ, Feb 5, 2020 Invited
Various applications of CRISPR library screening.

Atsushi Hoshino

Jan 29, 2020 Invited
CRISPR library screen application in cardiovascular research.

Atsushi Hoshino

CVMW 2019, The 36th ISHR Presidential Symposium., Dec 14, 2019 Invited
New players of Parkin-mediated mitophagy.

HOSHINO ATSUSHI

3rd BCVR, Sep 7, 2019 Invited
CRISPR library screen to identify novel regulators in Parkin-mediated mitophagy.

Atsushi Hoshino

Jul 20, 2019 Invited
The mitochondrial adenine nucleotide translocator mediates mitophagy independently of its nucleotide exchange activity.

HOSHINO ATSUSHI

ISHR XXII World Congress, Jun 3, 2019
Mitochondria-nucleus network for a novel therapy against heart failure.

HOSHINO ATSUSHI

2nd BCVR, Sep 23, 2018
Essential components to induce PINK1-Parkin mediated mitophagy.

HOSHINO ATSUSHI

2nd BCVR, Sep 22, 2018 Invited
CRISPRライブラリによるマイトファジー制御因子の同定とその応用

星野温

第27回日本Cell death 学会学術集会, Jul 27, 2018 Invited
Essential mitochondrial components to induce mitophagy.

HOSHINO ATSUSHI

ISCP 23rd Annual Scientific Meeting, May 28, 2018 Invited

Professional Memberships

Research Projects

線維化セクレトームの転写制御ネットワーク解明と心不全治療応用

科学研究費助成事業基盤研究(B), 日本学術振興会, Apr, 2022 - Mar, 2025

星野温
COVID-19に対する吸入ACE2デコイ製剤の開発

令和4年度「新興・再興感染症に対する革新的医薬品等開発推進研究事業」に係る追加公募, AMED, Jun, 2023 - Mar, 2024

星野温, 高木淳一, 岡本徹, 田原耕平, 坂井祐介, 諫田泰成
Development of precise base editor to prevent Alzheimer s disease

Oct, 2021 - Mar, 2024

Atsushi Hoshino Sasaguri Hiroki
高親和性ACE2による変異株を網羅したCOVID-19治療薬開発

令和4年度「新興・再興感染症に対する革新的医薬品等開発推進研究事業」に係る公募（3次公募）, AMED, Jul, 2022 - Mar, 2023

星野温, 高木淳一, 岡本徹, 齊藤暁, 保富康宏, 坂井祐介, 諫田泰成
高親和性ACE2による逃避変異を克服するCOVID-19治療薬の開発

新興・再興感染症に対する革新的医薬品等開発推進研究事業（新型コロナウイルス感染症（COVID-19）治療薬開発・ワクチン接種後の免疫反応解明）, AMED, Oct, 2021 - Mar, 2022

星野温, 高木淳一, 岡本徹, 齊藤暁, 保富康宏
Comprehensive analysis of aggregate-resistant structure and its application for disease prevention

Grants-in-Aid for Scientific Research Challenging Research (Exploratory), Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jul, 2020 - Mar, 2022

Hoshino Atsushi
Comprehensive analysis to uncover molecular network between mitochondria and nucleus underlying mitochondrial homeostasis

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

Hoshino Atsushi
Neutralizing antibody producing B cell deletion by CAR technology in Lysosomal diseases

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jun, 2019 - Mar, 2021

Gojo Satoshi
Resistance-free SARS-CoV-2 neutralizing drug development with high-affinity modified ACE2 protein.

Oct, 2020 - Mar, 2021
核－ミトコンドリア間ネットワークの解明と心不全治療応用

基礎研究助成, 日本循環器学会, Oct, 2018 - Sep, 2020

星野温
Development of synthetic Amyloid beta receptor for Alzheimer's disease therapy

Grants-in-Aid for Scientific Research Challenging Research (Exploratory), Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jun, 2018 - Mar, 2020

Hoshino Atsushi
核－ミトコンドリア間ネットワークの解明と心不全治療応用

研究奨励, 日本心臓財団, Apr, 2019 - Mar, 2020

星野温
合成アミロイドβ受容体を用いたアルツハイマー病の遺伝子細胞治療法開発

橋渡し研究戦略的推進プログラム（シーズA）, AMED, Apr, 2018 - Mar, 2019

星野温

Profile Information

Research Interests

Research Areas

Research History

Education

Awards

Major Papers

Misc.

Books and Other Publications

Presentations

Professional Memberships

Research Projects

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