2021年10月27日
Human hepatocyte-derived extracellular vesicles attenuate the carbon tetrachloride-induced acute liver injury in mice.
Cell death & disease
- 巻
- 12
- 号
- 11
- 開始ページ
- 1010
- 終了ページ
- 1010
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/s41419-021-04204-7
Acute liver injury (ALI) induced by chemicals or viruses can progress rapidly to acute liver failure (ALF), often resulting in death of patients without liver transplantation. Since liver transplantation is limited due to a paucity of donors, expensive surgical costs, and severe immune rejection, novel therapies are required to treat liver injury. Extracellular vesicles (EVs) are used for cellular communication, carrying RNAs, proteins, and lipids and delivering them intercellularly after being endocytosed by target cells. Recently, it was reported that EVs secreted from human hepatocytes have an ability to modulate the immune responses; however, these roles of EVs secreted from human hepatocytes were studied only with in vitro experiments. In the present study, we evidenced that EVs secreted from human hepatocytes attenuated the CCL4-induced ALI by inhibiting the recruitment of monocytes through downregulation of chemokine receptor in the bone marrow and recruitment of neutrophils through the reduction of C-X-C motif chemokine ligand 1 (CXCL1) and CXCL2 expression levels in the liver.
- リンク情報
-
- DOI
- https://doi.org/10.1038/s41419-021-04204-7
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/34707093
- PubMed Central
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551237
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85117917207&origin=inward 本文へのリンクあり
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85117917207&origin=inward
- ID情報
-
- DOI : 10.1038/s41419-021-04204-7
- eISSN : 2041-4889
- PubMed ID : 34707093
- PubMed Central 記事ID : PMC8551237
- SCOPUS ID : 85117917207