2017年12月
Imbalanced expression of polycistronic miRNA in acute myeloid leukemia.
International journal of hematology
- 巻
- 106
- 号
- 6
- 開始ページ
- 811
- 終了ページ
- 819
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1007/s12185-017-2314-1
- 出版者・発行元
- SPRINGER JAPAN KK
miR-1 and miR-133 are clustered on the same chromosomal loci and are transcribed together as a single transcript that is positively regulated by ecotropic virus integration site-1 (EVI1). Previously, we described how miR-133 has anti-tumorigenic potential through repression of EVI1 expression. It has also been reported that miR-1 is oncogenic in the case of acute myeloid leukemia (AML). Here, we show that expression of miR-1 and miR-133, which have distinct functions, is differentially regulated between AML cell lines. Interestingly, the expression of miR-1 and EVI1, which binds to the promoter of the miR-1/miR-133 cluster, is correlative. The expression levels of TDP-43, an RNA-binding protein that has been reported to increase the expression, but inhibits the activity, of miR-1, were not correlated with expression levels of miR-1 in AML cells. Taken together, our observations raise the possibility that the balance of polycistronic miRNAs is regulated post-transcriptionally in a hierarchical manner possibly involving EVI1, suggesting that the deregulation of this balance may play some role in AML cells with high EVI1 expression.
- リンク情報
- ID情報
-
- DOI : 10.1007/s12185-017-2314-1
- ISSN : 0925-5710
- eISSN : 1865-3774
- PubMed ID : 28831750
- Web of Science ID : WOS:000415648500011