Aoi Jitsuki-Takahashi

Profile Information

Affiliation: Tokyo Women's Medical University
: 横浜市立大学

J-GLOBAL ID: 201801013975643711
researchmap Member ID: B000323627

神経回路形成に重要な役割を果たす軸索ガイダンス分子をターゲットに生体内における様々なイベントを研究しています。

Research Areas

Life sciences / Neuroscience - general /

Papers

Clinical evidence that a dysregulated master neural network modulator may aid in diagnosing schizophrenia.

Munetaka Nomoto, Glenn T Konopaske, Naoya Yamashita, Reina Aoki, Aoi Jitsuki-Takahashi, Haruko Nakamura, Hiroko Makihara, Mari Saito, Yusuke Saigusa, Fumio Nakamura, Keisuke Watanabe, Toshihiko Baba, Francine M Benes, Brian T D Tobe, Cameron D Pernia, Joseph T Coyle, Richard L Sidman, Yoshio Hirayasu, Evan Y Snyder, Yoshio Goshima

Proceedings of the National Academy of Sciences of the United States of America, 118(31), Aug 3, 2021
Activity-induced secretion of semaphorin 3A mediates learning.

Aoi Jitsuki-Takahashi, Susumu Jitsuki, Naoya Yamashita, Meiko Kawamura, Manabu Abe, Kenji Sakimura, Akane Sano, Fumio Nakamura, Yoshio Goshima, Takuya Takahashi

The European journal of neuroscience, 53(10) 3279-3293, May, 2021
Phosphorylation of Collapsin Response Mediator Protein 1 (CRMP1) at Tyrosine 504 residue regulates Semaphorin 3A-induced cortical dendritic growth.

Takeshi Kawashima, Aoi Jitsuki-Takahashi, Kohtaro Takizawa, Susumu Jitsuki, Takuya Takahashi, Toshio Ohshima, Yoshio Goshima, Fumio Nakamura

Journal of neurochemistry, 157(4) 1207-1221, May, 2021
Network-guided analysis of hippocampal proteome identifies novel proteins that colocalize with Aβ in a mice model of early-stage Alzheimer's disease.

Aderemi Caleb Aladeokin, Tomoko Akiyama, Ayuko Kimura, Yayoi Kimura, Aoi Takahashi-Jitsuki, Haruko Nakamura, Hiroko Makihara, Daiki Masukawa, Jun Nakabayashi, Hisashi Hirano, Fumio Nakamura, Takashi Saito, Takaomi Saido, Yoshio Goshima

Neurobiology of disease, 132 104603-104603, Dec, 2019 Peer-reviewed
Proteome and behavioral alterations in phosphorylation-deficient mutant Collapsin Response Mediator Protein2 knock-in mice.

Haruko Nakamura, Aoi Takahashi-Jitsuki, Hiroko Makihara, Tetsuya Asano, Yayoi Kimura, Jun Nakabayashi, Naoya Yamashita, Yuko Kawamoto, Fumio Nakamura, Toshio Ohshima, Hisashi Hirano, Fumiaki Tanaka, Yoshio Goshima

Neurochemistry international, 119 207-217, Oct, 2018 Peer-reviewed
CRMP2-binding compound, edonerpic maleate, accelerates motor function recovery from brain damage

Hiroki Abe, Susumu Jitsuki, Waki Nakajima, Yumi Murata, Aoi Jitsuki-Takahashi, Yuki Katsuno, Hirobumi Tada, Akane Sano, Kumiko Suyama, Nobuyuki Mochizuki, Takashi Komori, Hitoshi Masuyama, Tomohiro Okuda, Yoshio Goshima, Noriyuki Higo, Takuya Takahashi

Science, 360(6384) 50-57, 2018 Peer-reviewed
Comprehensive behavioral study and proteomic analyses of CRMP2-deficient mice

Haruko Nakamura, Naoya Yamashita, Ayuko Kimura, Yayoi Kimura, Hisashi Hirano, Hiroko Makihara, Yuko Kawamoto, Aoi Jitsuki-Takahashi, Kumiko Yonezaki, Kenkichi Takase, Tomoyuki Miyazaki, Fumio Nakamura, Fumiaki Tanaka, Yoshio Goshima

GENES TO CELLS, 21(10) 1059-1079, Oct, 2016 Peer-reviewed
CRMP1 and CRMP2 have synergistic but distinct roles in dendritic development

Hiroko Makihara, Shiori Nakai, Wataru Ohkubo, Naoya Yamashita, Fumio Nakamura, Hiroshi Kiyonari, Go Shioi, Aoi Jitsuki-Takahashi, Haruko Nakamura, Fumiaki Tanaka, Tomoko Akase, Pappachan Kolattukudy, Yoshio Goshima

GENES TO CELLS, 21(9) 994-1005, Sep, 2016 Peer-reviewed
Nogo Receptor Signaling Restricts Adult Neural Plasticity by Limiting Synaptic AMPA Receptor Delivery

Susumu Jitsuki, Waki Nakajima, Kiwamu Takemoto, Akane Sano, Hirobumi Tada, Aoi Takahashi-Jitsuki, Takuya Takahashi

CEREBRAL CORTEX, 26(1) 427-439, Jan, 2016 Peer-reviewed
Voltage-gated calcium and sodium channels mediate Sema3A retrograde signaling that regulates dendritic development

Naoya Yamashita, Reina Aoki, Sandy Chen, Aoi Jitsuki-Takahashi, Shunsuke Ohura, Haruyuki Kamiya, Yoshio Goshima

BRAIN RESEARCH, 1631 127-136, Jan, 2016 Peer-reviewed
Anti-Semaphorin 3A neutralization monoclonal antibody prevents sepsis development in lipopolysaccharide-treated mice

*Naoya Yamashita, *Aoi Jitsuki-Takahashi, Miyuki Ogawara, Wataru Ohkubo, Tomomi Araki, Chie Hotta, Tomohiko Tamura, Shu-ichi Hashimoto, Takashi Yabuki, Toru Tsuji, Yukie Sasakura, Hiromi Okumura, Aki Takaiwa, Chika Koyama, Koji Murakami, Yoshio Goshima

INTERNATIONAL IMMUNOLOGY, 27(9) 459-466, Sep, 2015 Peer-reviewedLead author
Mice lacking collapsin response mediator protein 1 manifest hyperactivity, impaired learning and memory, and impaired prepulse inhibition

Naoya Yamashita, Aoi Takahashi, Keizo Takao, Toshifumi Yamamoto, Pappachan Kolattukudy, Tsuyoshi Miyakawa, Yoshio Goshima

FRONTIERS IN BEHAVIORAL NEUROSCIENCE, 7 216, Dec, 2013 Peer-reviewed
Serotonin Mediates Cross-Modal Reorganization of Cortical Circuits

Susumu Jitsuki, Kiwamu Takemoto, Taisuke Kawasaki, Hirobumi Tada, Aoi Takahashi, Carine Becamel, Akane Sano, Michisuke Yuzaki, R. Suzanne Zukin, Edward B. Ziff, Helmut W. Kessels, Takuya Takahashi

NEURON, 69(4) 780-792, Feb, 2011 Peer-reviewed

Misc.

Collapsin response mediator protein 1 (CRMP1) and CRMP2 mediate Semaphorin3A signaling through distinct pathway in vivo

Hiroko Makihara, Shiori Nakai, Aoi Jitsuki-Takahashi, Haruko Nakamura, Naoya. Yamashita, Hiroshi Kiyonari, Go Shioi, Fumio Nakamura, Fumiaki Tanaka, Yoshio Goshima

JOURNAL OF PHARMACOLOGICAL SCIENCES, 130(3) S155-S155, Mar, 2016

Research Projects

恐怖記憶形成過程における神経ガイダンス分子の複合効果機構の解明

科学研究費助成事業若手研究, 日本学術振興会, Apr, 2020 - Mar, 2023

實木葵
軸索ガイダンス分子の長期記憶形成における役割

科学研究費助成事業若手研究(B), 日本学術振興会, Apr, 2017 - Mar, 2020

實木葵
アルツハイマー病発症におけるセマフォリン3Aの役割

わかば研究助成, 横浜総合医学振興財団, Sep, 2016 - Sep, 2017

實木(高橋)葵
Semaphorin3Aシグナルのシナプス可塑性における役割

特別研究員奨励費（DC1）, 独立行政法人日本学術振興会, Apr, 2012 - Mar, 2015

高橋葵

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