論文

国際誌
2021年5月

Activity-induced secretion of semaphorin 3A mediates learning.

The European journal of neuroscience
  • Aoi Jitsuki-Takahashi
  • ,
  • Susumu Jitsuki
  • ,
  • Naoya Yamashita
  • ,
  • Meiko Kawamura
  • ,
  • Manabu Abe
  • ,
  • Kenji Sakimura
  • ,
  • Akane Sano
  • ,
  • Fumio Nakamura
  • ,
  • Yoshio Goshima
  • ,
  • Takuya Takahashi

53
10
開始ページ
3279
終了ページ
3293
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/ejn.15210

The semaphorin family is a well-characterized family of secreted or membrane-bound proteins that are involved in activity-independent neurodevelopmental processes, such as axon guidance, cell migration, and immune functions. Although semaphorins have recently been demonstrated to regulate activity-dependent synaptic scaling, their roles in Hebbian synaptic plasticity as well as learning and memory remain poorly understood. Here, using a rodent model, we found that an inhibitory avoidance task, a hippocampus-dependent contextual learning paradigm, increased secretion of semaphorin 3A in the hippocampus. Furthermore, the secreted semaphorin 3A in the hippocampus mediated contextual memory formation likely by driving AMPA receptors into hippocampal synapses via the neuropilin1-plexin A4-semaphorin receptor complex. This signaling process involves alteration of the phosphorylation status of collapsin response mediator protein 2, which has been characterized as a downstream molecule in semaphorin signaling. These findings implicate semaphorin family as a regulator of Hebbian synaptic plasticity and learning.

リンク情報
DOI
https://doi.org/10.1111/ejn.15210
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33772906
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252788
ID情報
  • DOI : 10.1111/ejn.15210
  • PubMed ID : 33772906
  • PubMed Central 記事ID : PMC8252788

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