論文

査読有り
2018年

CRMP2-binding compound, edonerpic maleate, accelerates motor function recovery from brain damage

Science
  • Hiroki Abe
  • ,
  • Susumu Jitsuki
  • ,
  • Waki Nakajima
  • ,
  • Yumi Murata
  • ,
  • Aoi Jitsuki-Takahashi
  • ,
  • Yuki Katsuno
  • ,
  • Hirobumi Tada
  • ,
  • Akane Sano
  • ,
  • Kumiko Suyama
  • ,
  • Nobuyuki Mochizuki
  • ,
  • Takashi Komori
  • ,
  • Hitoshi Masuyama
  • ,
  • Tomohiro Okuda
  • ,
  • Yoshio Goshima
  • ,
  • Noriyuki Higo
  • ,
  • Takuya Takahashi

360
6384
開始ページ
50
終了ページ
57
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1126/science.aao2300
出版者・発行元
American Association for the Advancement of Science

Brain damage such as stroke is a devastating neurological condition that may severely compromise patient quality of life. No effective medication-mediated intervention to accelerate rehabilitation has been established. We found that a small compound, edonerpic maleate, facilitated experience-driven synaptic glutamate AMPA (a-amino-3hydroxy-5-methyl-4-isoxazole-propionic-acid) receptor delivery and resulted in the acceleration of motor function recovery after motor cortex cryoinjury in mice in a training-dependent manner through cortical reorganization. Edonerpic bound to collapsin-response-mediator-protein 2 (CRMP2) and failed to augment recovery in CRMP2-deficient mice. Edonerpic maleate enhanced motor function recovery from internal capsule hemorrhage in nonhuman primates. Thus, edonerpic maleate, a neural plasticity enhancer, could be a clinically potent small compound with which to accelerate rehabilitation after brain damage.

リンク情報
DOI
https://doi.org/10.1126/science.aao2300
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29622647
ID情報
  • DOI : 10.1126/science.aao2300
  • ISSN : 1095-9203
  • ISSN : 0036-8075
  • PubMed ID : 29622647
  • SCOPUS ID : 85045000257

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