論文

査読有り
2016年1月

Nogo Receptor Signaling Restricts Adult Neural Plasticity by Limiting Synaptic AMPA Receptor Delivery

CEREBRAL CORTEX
  • Susumu Jitsuki
  • ,
  • Waki Nakajima
  • ,
  • Kiwamu Takemoto
  • ,
  • Akane Sano
  • ,
  • Hirobumi Tada
  • ,
  • Aoi Takahashi-Jitsuki
  • ,
  • Takuya Takahashi

26
1
開始ページ
427
終了ページ
439
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1093/cercor/bhv232
出版者・発行元
OXFORD UNIV PRESS INC

Experience-dependent plasticity is limited in the adult brain, and its molecular and cellular mechanisms are poorly understood. Removal of the myelin-inhibiting signaling protein, Nogo receptor (NgR1), restores adult neural plasticity. Here we found that, in NgR1-deficient mice, whisker experience-driven synaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR) insertion in the barrel cortex, which is normally complete by 2 weeks after birth, lasts into adulthood. In vivo live imaging by two-photon microscopy revealed more AMPAR on the surface of spines in the adult barrel cortex of NgR1-deficient than on those of wild-type (WT) mice. Furthermore, we observed that whisker stimulation produced new spines in the adult barrel cortex of mutant but not WT mice, and that the newly synthesized spines contained surface AMPAR. These results suggest that Nogo signaling limits plasticity by restricting synaptic AMPAR delivery in coordination with anatomical plasticity.

Web of Science ® 被引用回数 : 22

リンク情報
DOI
https://doi.org/10.1093/cercor/bhv232
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/26472557
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000370972500038&DestApp=WOS_CPL
ID情報
  • DOI : 10.1093/cercor/bhv232
  • ISSN : 1047-3211
  • eISSN : 1460-2199
  • PubMed ID : 26472557
  • Web of Science ID : WOS:000370972500038

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