論文

査読有り
2013年12月

Mice lacking collapsin response mediator protein 1 manifest hyperactivity, impaired learning and memory, and impaired prepulse inhibition

FRONTIERS IN BEHAVIORAL NEUROSCIENCE
  • Naoya Yamashita
  • ,
  • Aoi Takahashi
  • ,
  • Keizo Takao
  • ,
  • Toshifumi Yamamoto
  • ,
  • Pappachan Kolattukudy
  • ,
  • Tsuyoshi Miyakawa
  • ,
  • Yoshio Goshima

7
開始ページ
216
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3389/fnbeh.2013.00216
出版者・発行元
FRONTIERS RESEARCH FOUNDATION

Collapsin response mediator protein 1 (CRMP1) is one of the CRMP family members that are involved in various aspects of neuronal development such as axonal guidance and neuronal migration. Here we provide evidence that crmp1(-/-) mice exhibited behavioral abnormalities related to schizophrenia. The crmp1(-/-) mice exhibited hyperactivity and/or impaired emotional behavioral phenotype. These mice also exhibited impaired context-dependent memory and long-term memory retention. Furthermore, crmp1(-/-) mice exhibited decreased prepulse inhibition, and this phenotype was rescued by administration of chlorpromazine, a typical antipsychotic drug. In addition, in vivo microdialysis revealed that the methamphetamine-induced release of dopamine in prefrontal cortex was exaggerated in crmp1(-/-) mice, suggesting that enhanced mesocortical dopaminergic transmission contributes to their hyperactivity phenotype. These observations suggest that impairment of CRMP1 function may be involved in the pathogenesis of schizophrenia. We propose that crmp1(-/-) mouse may model endophenotypes present in this neuropsychiatric disorder.

Web of Science ® 被引用回数 : 18

リンク情報
DOI
https://doi.org/10.3389/fnbeh.2013.00216
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/24409129
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000329176500001&DestApp=WOS_CPL
ID情報
  • DOI : 10.3389/fnbeh.2013.00216
  • ISSN : 1662-5153
  • PubMed ID : 24409129
  • Web of Science ID : WOS:000329176500001

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