論文

査読有り
2011年2月

Serotonin Mediates Cross-Modal Reorganization of Cortical Circuits

NEURON
  • Susumu Jitsuki
  • ,
  • Kiwamu Takemoto
  • ,
  • Taisuke Kawasaki
  • ,
  • Hirobumi Tada
  • ,
  • Aoi Takahashi
  • ,
  • Carine Becamel
  • ,
  • Akane Sano
  • ,
  • Michisuke Yuzaki
  • ,
  • R. Suzanne Zukin
  • ,
  • Edward B. Ziff
  • ,
  • Helmut W. Kessels
  • ,
  • Takuya Takahashi

69
4
開始ページ
780
終了ページ
792
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.neuron.2011.01.016
出版者・発行元
CELL PRESS

Loss of one type of sensory input can cause improved functionality of other sensory systems. Whereas this form of plasticity, cross-modal plasticity, is well established, the molecular and cellular mechanisms underlying it are still unclear. Here, we show that visual deprivation (VD) increases extracellular serotonin in the juvenile rat barrel cortex. This increase in serotonin levels facilitates synaptic strengthening at layer 4 to layer 2/3 synapses within the barrel cortex. Upon VD, whisker experience leads to trafficking of the AMPA-type glutamate receptors (AMPARs) into these synapses through the activation of ERK and increased phosphorylation of AMPAR subunit GluR1 at the juvenile age when natural whisker experience no longer induces synaptic GluR1 delivery. VD thereby leads to sharpening of the functional whisker-barrel map at layer 2/3. Thus, sensory deprivation of one modality leads to serotonin release in remaining modalities, facilitates GluR1-dependent synaptic strengthening, and refines cortical organization.

Web of Science ® 被引用回数 : 94

リンク情報
DOI
https://doi.org/10.1016/j.neuron.2011.01.016
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/21338886
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000288413200018&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.neuron.2011.01.016
  • ISSN : 0896-6273
  • PubMed ID : 21338886
  • Web of Science ID : WOS:000288413200018

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