論文

査読有り 国際誌
2020年3月20日

Effects of lipid metabolism on mouse incisor dentinogenesis.

Scientific reports
  • Yutaro Kurotaki
  • ,
  • Nobuhiro Sakai
  • ,
  • Takuro Miyazaki
  • ,
  • Masahiro Hosonuma
  • ,
  • Yurie Sato
  • ,
  • Akiko Karakawa
  • ,
  • Masahiro Chatani
  • ,
  • Mie Myers
  • ,
  • Tetsuo Suzawa
  • ,
  • Takako Negishi-Koga
  • ,
  • Ryutaro Kamijo
  • ,
  • Akira Miyazaki
  • ,
  • Yasubumi Maruoka
  • ,
  • Masamichi Takami

10
1
開始ページ
5102
終了ページ
5102
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/s41598-020-61978-0

Tooth formation can be affected by various factors, such as oral disease, drug administration, and systemic illness, as well as internal conditions including dentin formation. Dyslipidemia is an important lifestyle disease, though the relationship of aberrant lipid metabolism with tooth formation has not been clarified. This study was performed to examine the effects of dyslipidemia on tooth formation and tooth development. Dyslipidemia was induced in mice by giving a high-fat diet (HFD) for 12 weeks. Additionally, LDL receptor-deficient (Ldlr-/-) strain mice were used to analyze the effects of dyslipidemia and lipid metabolism in greater detail. In the HFD-fed mice, incisor elongation was decreased and pulp was significantly narrowed, while histological findings revealed disappearance of predentin. In Ldlr-/- mice fed regular chow, incisor elongation showed a decreasing trend and pulp a narrowing trend, while predentin changes were unclear. Serum lipid levels were increased in the HFD-fed wild-type (WT) mice, while Ldlr-/- mice given the HFD showed the greatest increase. These results show important effects of lipid metabolism, especially via the LDL receptor, on tooth homeostasis maintenance. In addition, they suggest a different mechanism for WT and Ldlr-/- mice, though the LDL receptor pathway may not be the only factor involved.

リンク情報
DOI
https://doi.org/10.1038/s41598-020-61978-0
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32198436
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083963

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