Ayano Kawaguchi

Profile Information

Affiliation: Graduate School of Medicine , Dentistry and Pharmaceutical Sciences, Okayama University

Degree: 博士(医学）(大阪大学)

Researcher number: 90360528
ORCID ID: https://orcid.org/0000-0002-0339-3992
J-GLOBAL ID: 201101046021393912
researchmap Member ID: B000004836

External link: https://www.okayama-u-humanmorphology.website/

頑強な脳発生に貢献する、神経前駆細胞の運命決定の仕組みに興味を持って研究を行っています。

Research Interests

Research Areas

Research History

Dec, 2022 - Present

School of Medicine, Nagoya University
Jun, 2022 - Present

Okayama University
Apr, 2024 - Mar, 2025

大阪大学医学系研究科委託講師（兼任）
2008 - 2022

Graduate School of Medicine, Nagoya University
2002 - 2008

RIKEN
2001 - 2002

特別研究員 (DC2), 日本学術振興会

Education

Apr, 1998 - Mar, 2002

Graduate School of Medicine, Osaka University
Apr, 1989 - Mar, 1995

Medical School, Faculty of Medicine, Osaka University

Committee Memberships

Jun, 2022

代議員, 日本解剖学会

Papers

Calcium signals tune AMPK activity and mitochondrial homeostasis in dendrites of developing neurons

Akane Hatsuda, Junko Kurisu, Kazuto Fujishima, Ayano Kawaguchi, Nobuhiko Ohno, Mineko Kengaku

Development, 150(21), Nov, 2023 Peer-reviewed
Advanced Techniques Using In Vivo Electroporation to Study the Molecular Mechanisms of Cerebral Development Disorders

Chen Yang, Atsunori Shitamukai, Shucai Yang, Ayano Kawaguchi

International Journal of Molecular Sciences, 24(18) 14128-14128, Sep 15, 2023 Peer-reviewedInvitedLast authorCorresponding author
CD206+ macrophages transventricularly infiltrate the early embryonic cerebral wall to differentiate into microglia

Yuki Hattori, Daisuke Kato, Futoshi Murayama, Sota Koike, Hisa Asai, Ayato Yamasaki, Yu Naito, Ayano Kawaguchi, Hiroyuki Konishi, Marco Prinz …

Cell Reports, 42(2) 112092-112092, Feb, 2023 Peer-reviewed
Neuronal delamination and outer radial glia generation in neocortical development

Kawaguchi A

Frontiers Cell and Developmental Biology, 8 623573, Feb, 2021 Peer-reviewedLast authorCorresponding author
Transient microglial absence assists postmigratory cortical neurons in proper differentiation.

Yuki Hattori, Yu Naito, Yoji Tsugawa, Shigenori Nonaka, Hiroaki Wake, Takashi Nagasawa, Ayano Kawaguchi, Takaki Miyata

Nature communications, 11(1) 1631-1631, Apr 2, 2020 Peer-reviewed
Lzts1 controls both neuronal delamination and outer radial glial-like cell generation during mammalian cerebral development.

Kawaue T, Shitamukai A, Nagasaka A, Tsunekawa Y, Shinoda T, Saito K, Terada R, Bilgic M, Miyata T, Matsuzaki F …

Nature Communications, 10(1) 2780-2780, Jun, 2019 Peer-reviewedCorresponding author
Temporal patterning of neocortical progenitor cells: how do they know the right time?

Kawaguchi A

Neuroscience Research, 138 3-11, Jan, 2019 Peer-reviewedCorresponding author
Neural Progenitor Cells Undergoing Yap/Tead-Mediated Enhanced Self-Renewal Form Heterotopias More Easily in the Diencephalon than in the Telencephalon

Kanako Saito, Ryotaro Kawasoe, Hiroshi Sasaki, Ayano Kawaguchi, Takaki Miyata

Neurochemical Research, 43(1) 171-180, Jan 1, 2018 Peer-reviewed
Division modes and physical asymmetry in cerebral cortex progenitors

Delphine Delaunay, Ayano Kawaguchi, Colette Dehay, Fumio Matsuzaki

CURRENT OPINION IN NEUROBIOLOGY, 42 75-83, Feb, 2017 Peer-reviewed
Differences in the Mechanical Properties of the Developing Cerebral Cortical Proliferative Zone between Mice and Ferrets at both the Tissue and Single-Cell Levels.

Nagasaka A, Shinoda T, Kawaue T, Suzuki M, Nagayama K, Matsumoto T, Ueno N, Kawaguchi A, Miyata T

Frontiers in cell and developmental biology, 4 139, Nov, 2016 Peer-reviewed
Cell-cycle-independent transitions in temporal identity of mammalian neural progenitor cells

Mayumi Okamoto, Takaki Miyata, Daijiro Konno, Hiroki R. Ueda, Takeya Kasukawa, Mitsuhiro Hashimoto, Fumio Matsuzaki, Ayano Kawaguchi

NATURE COMMUNICATIONS, 7 11349, Apr, 2016 Peer-reviewedCorresponding author
Cell cycle-arrested cells know the right time

Ayano Kawaguchi, Fumio Matsuzaki

CELL CYCLE, 15(20) 2683-2684, 2016 Peer-reviewedCorresponding author
Interkinetic nuclear migration generates and opposes ventricular-zone crowding: insight into tissue mechanics

Takaki Miyata, Mayumi Okamoto, Tomoyasu Shinoda, Ayano Kawaguchi

FRONTIERS IN CELLULAR NEUROSCIENCE, 8 473, Jan, 2015 Peer-reviewed
Neurogenin2-d4Venus and Gadd45g-d4Venus transgenic mice: Visualizing mitotic and migratory behaviors of cells committed to the neuronal lineage in the developing mammalian brain

Takumi Kawaue, Ken Sagou, Hiroshi Kiyonari, Kumiko Ota, Mayumi Okamoto, Tomoyasu Shinoda, Ayano Kawaguchi, Takaki Miyata

DEVELOPMENT GROWTH & DIFFERENTIATION, 56(4) 293-304, May, 2014 Peer-reviewed
TAG-1-assisted progenitor elongation streamlines nuclear migration to optimize subapical crowding

Mayumi Okamoto, Takashi Namba, Tomoyasu Shinoda, Takefumi Kondo, Tadashi Watanabe, Yasuhiro Inoue, Kosei Takeuchi, Yukiko Enomoto, Kumiko Ota, Kanako Oda …

NATURE NEUROSCIENCE, 16(11) 1556-1566, Nov, 2013 Peer-reviewed
Migration, early axonogenesis, and Reelin-dependent layer-forming behavior of early/posterior-born Purkinje cells in the developing mouse lateral cerebellum

Takaki Miyata, Yuichi Ono, Mayumi Okamoto, Makoto Masaoka, Akira Sakakibara, Ayano Kawaguchi, Mitsuhiro Hashimoto, Masaharu Ogawa

NEURAL DEVELOPMENT, 5 23, Sep, 2010 Peer-reviewed
Lunatic fringe potentiates Notch signaling in the developing brain

Tomoaki M. Kato, Ayano Kawaguchi, Yoichi Kosodo, Hitoshi Niwa, Fumio Matsuzaki

MOLECULAR AND CELLULAR NEUROSCIENCE, 45(1) 12-25, Sep, 2010 Peer-reviewed
Mechanisms that regulate the number of neurons during mouse neocortical development

Takaki Miyata, Daichi Kawaguchi, Ayano Kawaguchi, Yukiko Gotoh

CURRENT OPINION IN NEUROBIOLOGY, 20(1) 22-28, Feb, 2010 Peer-reviewed
Single-cell gene profiling defines differential progenitor subclasses in mammalian neurogenesis

Ayano Kawaguchi, Tomoko Ikawa, Takeya Kasukawa, Hiroki R. Ueda, Kazuki Kurimoto, Mitinori Saitou, Fumio Matsuzaki

DEVELOPMENT, 135(18) 3113-3124, Sep, 2008 Peer-reviewedCorresponding author
Differential expression of Pax6 and Ngn2 between pair-generated cortical neurons

A Kawaguchi, M Ogawa, K Saito, F Matsuzaki, H Okano, T Miyata

JOURNAL OF NEUROSCIENCE RESEARCH, 78(6) 784-795, Dec, 2004 Peer-reviewedCorresponding author

Misc.

Regulation of neural stem cell morphology in brain

55(10) 850-853, Aug, 2023 InvitedLast authorCorresponding author
Morphological perspectives on the fate determination of neural progenitor cells

Ayano Kawaguchi

Journal of Okayama Medical Association, 135(1) 12-17, Apr, 2023 InvitedLead authorLast authorCorresponding author
細胞離脱の実行役分子Lzts1による大脳形成制御

川口綾乃

生化学, 92(6) 817-821, Dec, 2020 Peer-reviewed
非対称分裂

川口綾乃, 松崎文雄

分子細胞治療, 3(1) 138-139, 2004
実験講座胎生期大脳組織の三次元培養:複雑さへの回帰

宮田卓樹, 齋藤加奈子, 川口綾乃

生体の科学, 53(3) 243-249, May, 2002
発達脳における神経細胞の移動:新しいニューロン移動法とその原理 (特集脳の発達に関与する分子機構)

宮田卓樹, 川口綾乃, 岡野栄之

生体の科学, 52(3) 224-229, May, 2001
神経系前駆細胞及び成熟ニューロンの非対称性に関する細胞生物学的解析

岡野栄之, 飯島崇利, 川口綾乃, 宮田卓樹, 今井貴雄, 小川正晴

日本分子生物学会年会プログラム・講演要旨集, 23rd 292, Nov 25, 2000
神経幹細胞の同定--中枢神経系の再生を目指して (特集幹細胞システムと再生医学)

川口綾乃, 岡野栄之

細胞工学, 19(3) 392-397, Mar, 2000
FACSを用いた神経系前駆細胞の分離

川口綾乃, 岡野栄之

実験医学, 18 1106-1108, 2000
神経幹細胞の同定とその中枢神経再生への応用の展望

川口綾乃, 岡野栄之

最新医学, 54 1721-1729, 1999

Professional Memberships

Research Projects

上皮構造からの細胞離脱による器官形成制御

創発的研究支援事業 (フェーズ1), 科学技術振興機構(JST), 2022 - 2024

川口綾乃
上皮構造からの細胞の離脱・移動の新しい分子制御機構

研究助成金, 上原記念生命科学財団, 2022 - 2023

川口綾乃
異所性灰白質病態と脳進化に関わる脳室下帯の形成メカニズムの解明

科学研究費補助金基盤B, 文部科学省, 2020 - 2023

川口綾乃
場の変化が明らかにする神経前駆細胞の時間個性獲得の機構

科学研究費補助金新学術領域(公募研究), 文部科学省, 2019 - 2020

川口綾乃
脳室帯のシステム科学的研究

科学研究費補助金基盤A, 文部科学省, 2016 - 2020

宮田卓樹
大脳発生過程における脳室面からの細胞離脱制御

科学研究費補助金基盤Ｃ, 文部科学省, 2016 - 2019

川口綾乃
大脳皮質の脳回形成に寄与する神経前駆細胞移動の分子機構

第27回研究助成, 堀科学芸術振興財団, 2018 - 2018

川口綾乃
Outer radial glia誕生がもたらす神経幹細胞の場と時間特性の変化

科学研究費補助金新学術領域（公募研究）, 文部科学省, 2017 - 2018

川口綾乃
Neurogenesis regulated through three-dimensional cellular movement and cell-cell interactions within the neuroepithelium

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Apr, 2010 - Mar, 2016

Miyata Takaki, KAWAGUCHI Ayano, SAKAKIBARA Akira, HASHIMOTO Mitsuhiro, SHINODA Tomoyasu, OKAMOTO Mayumi
神経幹細胞の分化に際し速やかに発現変動する遺伝子の脳組織形成への関与

科学研究費補助金基盤Ｃ, 文部科学省, 2013 - 2016

川口綾乃
発生時期による神経幹細胞の分裂パターンの変化を制御する機構の解明

科学研究費補助金新学術領域（公募研究）, 文部科学省, 2011 - 2012

川口綾乃
発生期の脳組織中で神経幹細胞の維持と分化を制御する機構の解明

科学研究費補助金基盤Ｃ, 文部科学省, 2010 - 2012

川口綾乃
小脳発生の研究:胎生期のニューロン誕生・移動の機構

科学研究費補助金基盤A, 文部科学省, 2009 - 2012

宮田卓樹
単一細胞マイクロアレイ法を用いた神経前駆細胞の時期特異的な分化制御機構の解析

H20年度第２回学術研究助成, 名古屋大学学術振興基金, 2008 - 2010

川口綾乃
単一細胞遺伝子発現解析法を用いた、ほ乳類中枢神経系の前駆細胞の運命決定因子の探索

科学研究費補助金若手(A), 文部科学省, 2006 - 2007

川口綾乃
哺乳類中枢神経系における非対称分裂を介した細胞運命決定機構の解析

科学研究費補助金若手(Ｂ), 文部科学省, 2003 - 2005

川口綾乃
中枢神経系幹細胞による細胞産生、組織構築のメカニズムの解明

特別研究奨励費, 特別研究員奨励費, 日本学術振興会, 2001 - 2001

川口綾乃

Profile Information

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Research History

Education

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Papers

Misc.

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