Apr, 2013 - Mar, 2016
Possibility of bone metabolism improvement by health food with medication
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research Grant-in-Aid for Challenging Exploratory Research
- Grant number
- 25670815
- Japan Grant Number (JGN)
- JP25670815
- Grant amount
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- (Total)
- 3,640,000 Japanese Yen
- (Direct funding)
- 2,800,000 Japanese Yen
- (Indirect funding)
- 840,000 Japanese Yen
The present study aimed to evaluate the effect of the functional foods for prevention of osteoporosis. We established osteoporosis model rat using ovariectomy operation. Sham operation was used for control. Before or after operation, Functional foods were fed to model animals. Two, 4 and 8 weeks after operation, Tibiae and femurs were collected. Samples were analyzed by micro-CT, three point bending test and Histological staining. Micro-CT images showed that cancellous bone mass in OVX-rats were decreasing from 4 weeks and reached 50% on 8 weeks after operation. Histological sections indicated that bone mineral density and amount of crosslinking were increased in Royal jelly diet and black vinegar diet samples. However, Bone volume and Breaking strength in Royal jelly diet and black vinegar diet samples showed no difference compare to the control.
- Link information
- ID information
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- Grant number : 25670815
- Japan Grant Number (JGN) : JP25670815