Osteoporosis is one of the risk factor for implant therapy. Curcumin is known as a functional healthy food and able to remove active oxygen spices. Curcumin thought to be contributed to help bone formation and save people from osteoporosis. The aim of this study is to elucidate the mechanisms of acceleration for bone formation by curcumin. We fed curcumin to the normal rat and OVX rat, then observed maxillary cylindrical cavity healing, calvarias defect and femoral defect. Among these all samples, there are no significant difference could be seen.