2015年1月26日
Total Synthesis of (+)-Vibsanin A
Organic Letters
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- 巻
- 17
- 号
- 3
- 開始ページ
- 756
- 終了ページ
- 759
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1021/acs.orglett.5b00086
- 出版者・発行元
- American Chemical Society
The first total synthesis of (+)-vibsanin A, an 11-membered vibsane diterpenoid, was achieved, unambiguously establishing its relative and absolute stereochemistry. Highlights of the synthesis include the stereoselective formation of an all-carbon quaternary stereocenter by a zinc-mediated Barbier-type allylation in an aqueous medium, and the efficient construction of an 11-membered ring skeleton by a combination of an intramolecular Nozaki-Hiyama-Kishi (NHK) reaction and a Mitsunobu reaction.
- リンク情報
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- DOI
- https://doi.org/10.1021/acs.orglett.5b00086
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/25622000
- URL
- https://pubs.acs.org/doi/10.1021/acs.orglett.5b00086
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84922642130&origin=inward
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84922642130&origin=inward
- ID情報
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- DOI : 10.1021/acs.orglett.5b00086
- ISSN : 1523-7060
- eISSN : 1523-7052
- PubMed ID : 25622000
- SCOPUS ID : 84922642130