An infected patient with new swine influenza (A/H1N1) at the first case in Japan was confirmed in Kobe City in May, 2009. We arranged and analyzed the responses that government of Kobe City had done. As a result, they were divided into six phases. In this paper, it explains a social situation in each phase and the feature of response. Government of Kobe City corresponded flexibly according to the situation of the site while referring to the response plan made beforehand. The purpose of this paper is to clarify the reason why the responses of government of Kobe City to the first domestic case were good.