2008年8月
Basolateral amygdala neurons facilitate reward-seeking behavior by exciting nucleus accumbens neurons
NEURON
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- 巻
- 59
- 号
- 4
- 開始ページ
- 648
- 終了ページ
- 661
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1016/j.neuron.2008.07.004
- 出版者・発行元
- CELL PRESS
Both the nucleus accumbens (NAc) and basolateral amygdala (BLA) contribute to learned behavioral choice. Neurons in both structures that encode reward-predictive cues may underlie the decision to respond to such cues, but the neural circuits by which the BLA influences reward-seeking behavior have not been established. Here, we test the hypothesi's that the BLA drives NAc neuronal responses to reward-predictive cues. First, using a disconnection experiment, we show that the BLA and dopamine projections to the NAc interact to promote the reward-seeking behavioral response. Next, we demonstrate that BLA neuronal responses to cues precede those of NAc neurons and that cue-evoked excitation of NAc neurons depends on BLA input. These results indicate that BLA input is required for dopamine to enhance the cue-evoked firing of NAc neurons and that this enhanced firing promotes reward-seeking behavior.
- リンク情報
- ID情報
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- DOI : 10.1016/j.neuron.2008.07.004
- ISSN : 0896-6273
- PubMed ID : 18760700
- Web of Science ID : WOS:000258944900014