Aki Sho

Profile Information

Affiliation: Research Center for Advanced Science and Technology, The University of Tokyo

J-GLOBAL ID: 201901017810199283
researchmap Member ID: B000371699

Research Interests

Research Areas

Research History

Jan, 2021 - Present

The University of Tokyo
Jul, 2015 - Dec, 2020

Kanazawa University

Committee Memberships

2022 - Present

評議員, 日本血管生物医学会
2019 - Present

評議員, 日本生理学会

Awards

May, 2023

血管生物若手研究会最優秀賞, 血管生物医学会
Dec, 2022

循環医学分野若手研究者助成, 先進医薬研究振興財団
Jul, 2022

がんと代謝研究会ポスター賞, がんと代謝研究会
Jul, 2022

がんと代謝若手研究会最優秀賞, がんと代謝研究会
Mar, 2022

入澤宏・彩記念若手研究奨励賞日本生理学会奨励賞, 日本生理学会
Sep, 2021

武田科学振興財団医学系研究助成
Sep, 2020

第34回北國がん基金
Jul, 2016

第14回高安賞優秀論文賞

安藝翔
Mar, 2016

第2回血管生物若手研究会最優秀賞

安藝翔
Jul, 2015

ONO Pharmaceutical Travel Awards for Young Japanese Investigators. 14th International Conference on Bioactive Lipids in Cancer, Inflammation and Related Diseases.

Aki Sho

Papers

Antibody-mimetic drug conjugate with efficient internalization activity using anti-HER2 VHH and duocarmycin

Juri Sakata, Toshifumi Tatsumi, Akira Sugiyama, Akihiro Shimizu, Yuya Inagaki, Hiroto Katoh, Takefumi Yamashita, Kazuki Takahashi, Sho Aki, Yudai Kaneko …

Protein Expression and Purification, 214 106375-106375, Feb, 2024
Hypoxia activates SREBP2 through Golgi disassembly in bone marrow-derived monocytes for enhanced tumor growth.

Ryuichi Nakahara, Sho Aki, Maki Sugaya, Haruka Hirose, Miki Kato, Keisuke Maeda, Daichi M Sakamoto, Yasuhiro Kojima, Miyuki Nishida, Ritsuko Ando …

The EMBO journal, 42(22) e114032, Oct 2, 2023
Acidic extracellular pH drives accumulation of N1-acetylspermidine and recruitment of protumor neutrophils.

Miki Kato, Keisuke Maeda, Ryuichi Nakahara, Haruka Hirose, Ayano Kondo, Sho Aki, Maki Sugaya, Sana Hibino, Miyuki Nishida, Manami Hasegawa …

PNAS nexus, 2(10) pgad306, Oct, 2023
Convergent genomic diversity and novel BCAA metabolism in intrahepatic cholangiocarcinoma.

Akihiro Kitagawa, Tsuyoshi Osawa, Miwa Noda, Yuta Kobayashi, Sho Aki, Yusuke Nakano, Tomoko Saito, Dai Shimizu, Hisateru Komatsu, Maki Sugaya …

British journal of cancer, 128(12) 2206-2217, Jun, 2023
Cancer metabolism within tumor microenvironments.

Sho Aki, Ryuichi Nakahara, Keisuke Maeda, Tsuyoshi Osawa

Biochimica et biophysica acta. General subjects, 1867(5) 130330-130330, May, 2023
Metabolic adaptations of cancer in extreme tumor microenvironments.

Ryuichi Nakahara, Keisuke Maeda, Sho Aki, Tsuyoshi Osawa

Cancer science, 114(4) 1200-1207, Apr, 2023
Pathological complete remission of relapsed tumor by photo-activating antibody-mimetic drug conjugate treatment.

Yudai Kaneko, Kenzo Yamatsugu, Takefumi Yamashita, Kazuki Takahashi, Toshiya Tanaka, Sho Aki, Toshifumi Tatsumi, Takeshi Kawamura, Mai Miura, Masazumi Ishii …

Cancer science, 113(12) 4350-4362, Dec, 2022
Antibody mimetic drug conjugate manufactured by high-yield Escherichia coli expression and non-covalent binding system.

Kenzo Yamatsugu, Hiroto Katoh, Takefumi Yamashita, Kazuki Takahashi, Sho Aki, Toshifumi Tatsumi, Yudai Kaneko, Takeshi Kawamura, Mai Miura, Masazumi Ishii …

Protein expression and purification, 192 106043-106043, Apr, 2022
Class II phosphatidylinositol 3-kinase-C2α is essential for Notch signaling by regulating the endocytosis of γ-secretase in endothelial cells

Shota Shimizu, Kazuaki Yoshioka, Sho Aki, Yoh Takuwa

Scientific Reports, 11(1) 5199-5199, Dec, 2021
Class II phosphatidylinositol 3-kinase α and β isoforms are required for vascular smooth muscle Rho activation, contraction and blood pressure regulation in mice.

Shahidul Islam, Kazuaki Yoshioka, Sho Aki, Kazuhiro Ishimaru, Hiroki Yamada, Noriko Takuwa, Yoh Takuwa

The journal of physiological sciences : JPS, 70(1) 18-18, Mar 19, 2020 Peer-reviewed
TGFβ receptor endocytosis and Smad signaling require synaptojanin1-, PI3K-C2α-, and INPP4B-mediated phosphoinositide conversions.

Aki S, Yoshioka K, Takuwa N, Takuwa Y

Mol Biol Cell., 31(5) 360-372, Mar 1, 2020 Peer-reviewed
The class II phosphoinositide 3-kinases PI3K-C2α and PI3K-C2β differentially regulate clathrin-dependent pinocytosis in human vascular endothelial cells.

Aung KT, Yoshioka K, Aki S, Ishimaru K, Takuwa N, Takuwa Y

The journal of physiological sciences : JPS, 69(2) 263-280, Mar, 2019 Peer-reviewed
Class II PI3Ks α and β Are Required for Rho-Dependent Uterine Smooth Muscle Contraction and Parturition in Mice.

Sarker MAK, Aki S, Yoshioka K, Kuno K, Okamoto Y, Ishimaru K, Takuwa N, Takuwa Y

Endocrinology, 160(1) 235-248, Jan, 2019 Peer-reviewed
MTMR4, a phosphoinositide-specific 3'-phosphatase, regulates TFEB activity and the endocytic and autophagic pathways.

Pham HQ, Yoshioka K, Mohri H, Nakata H, Aki S, Ishimaru K, Takuwa N, Takuwa Y

Genes to cells : devoted to molecular & cellular mechanisms, Jul, 2018 Peer-reviewed
Sphingosine-1-phosphate receptor-2 facilitates pulmonary fibrosis through potentiating IL-13 pathway in macrophages

Juanjuan Zhao, Yasuo Okamoto, Yuya Asano, Kazuhiro Ishimaru, Sho Aki, Kazuaki Yoshioka, Noriko Takuwa, Takashi Wada, Yutaka Inagaki, Chiaki Takahashi …

PLoS ONE, 13(5) e0197604, May 1, 2018 Peer-reviewed
Photoacoustic imaging of tumour vascular permeability with indocyanine green in a mouse model.

Kenichiro Okumura, Kotaro Yoshida, Kazuaki Yoshioka, Sho Aki, Norihide Yoneda, Dai Inoue, Azusa Kitao, Takahiro Ogi, Kazuto Kozaka, Tetsuya Minami …

European radiology experimental, 2(1) 5-5, 2018 Peer-reviewed
Phosphatidylinositol 3-Kinase Class II alpha-Isoform PI3K-C2 alpha Is Required for Transforming Growth Factor beta-induced Smad Signaling in Endothelial Cells

Sho Aki, Kazuaki Yoshioka, Yasuo Okamoto, Noriko Takuwa, Yoh Takuwa

JOURNAL OF BIOLOGICAL CHEMISTRY, 290(10) 6086-6105, Mar, 2015 Peer-reviewed
Endothelial PI3K-C2 alpha, a class II PI3K, has an essential role in angiogenesis and vascular barrier function

Kazuaki Yoshioka, Kotaro Yoshida, Hong Cui, Tomohiko Wakayama, Noriko Takuwa, Yasuo Okamoto, Wa Du, Xun Qi, Ken Asanuma, Kazushi Sugihara …

NATURE MEDICINE, 18(10) 1560-U170, Oct, 2012 Peer-reviewed

Misc.

Understanding cell-cell to cell-organelle to organelle mediated diseases

安藝翔, 大澤毅

実験医学, 41(15), 2023
クラスII PI3K はエンドサイトーシスを制御して血管新生に関与する

安藝翔

月刊「細胞」特集 : 血管のバイオロジー, Nov, 2018 Invited
内胸動脈グラフトの血管攣縮に対するRho‐kinase inhibitor(Fasudil)の抗攣縮効果

西田洋児, 安藝翔, 山本宜孝, 加藤寛城, 飯野賢治, 木村圭一, 多久和陽, 竹村博文

日本外科学会定期学術集会(Web), 118th ROMBUNNO.PS‐196‐3 (WEB ONLY), 2018
Phosphatidylinositol 3-kinase class IIα-isoform PI3K-C2α is required for transforming growth factor β-induced Smad signaling in endothelial cells

125(2) 73-74, Jun 1, 2016
Phosphatidylinositol 3-kinase class II α isoform (PI3K-C2α) maintains vascular integrity

Saori Koizumi, Kazuaki Yoshioka, Sho Aki, Yoh Takuwa

The Juzen Medical Society Kanazawa University, 125(2) 77-78, Jun, 2016 Invited
ICGを用いたマウスリアルタイム光音響イメージングの検討(Usefulness of indocyanine green contrast agent for photoacoustic imaging in an in vivo mouse model)

吉田耕太郎, 奥村健一朗, 井上大, 南哲弥, 香田渉, 蒲田敏文, 安藝翔, 吉岡和晃, 多久和陽

JSMI Report, 9(2) 169-169, Apr, 2016
インドシアニングリーンを用いた光音響イメージングの生体への応用

奥村健一朗, 吉田耕太郎, 井上大, 南哲弥, 香田渉, 小林聡, 蒲田敏文, 安藝翔, 吉岡和晃, 多久和陽

日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 88回・38回 [3P1286]-[3P1286], Dec, 2015
Sphingosine-1-phosphate receptor-2 plays a protective role against anaphylactic shock through inhibiting eNOS

Cui Hong, Okamoto Yasuo, Yoshioka Kazuaki, Du Wa, Takuwa Noriko, Zhang Wei, Biswas Kuntal, Aki Sho, Zhao JuanJuan, Kuda Yuichi …

JOURNAL OF PHYSIOLOGICAL SCIENCES, 63 S119, 2013 Peer-reviewed
Class II PI3 kinase-C2 alpha plays essential roles in endosomal Rac1 activation and cell migration in S1P-stimulated endothelial cells

Biswas Kuntal, Yoshioka Kazuaki, Aki Sho, Cui Hong, Zhao JuanJuan, Kuda Yuichi, Takuwa Noriko, Okamoto Yasuo, Takuwa Yoh

JOURNAL OF PHYSIOLOGICAL SCIENCES, 63 S136, 2013 Peer-reviewed
Essential role of phophatidyilinositol 3-kinase class IIα isoform (PI3K-C2α) in TGFβ1-induced angiogenesis

AKI Sho

119(2) 42-43, Jun 1, 2010
Physiological role of class II PI3K-C2 alpha for vascular formation: conditional knockout mouse study

Yoshioka Kazuaki, Yoshida Kotaro, Aki Sho, Biswas Kuntal, Du Wa, Qin Xun, Wang Fei, Takuwa Noriko, Okamoto Yasuo, Takuwa Yoh

JOURNAL OF PHYSIOLOGICAL SCIENCES, 60 S76, 2010 Peer-reviewed
Class II PI3K-C2 alpha regulates angiogenesis via TGF beta 1-Smad2/3 signaling in endothelial cell

Aki Sho, Yoshioka Kazuaki, Okamoto Yasuo, Takuwa Yoh

JOURNAL OF PHYSIOLOGICAL SCIENCES, 60 S76, 2010 Peer-reviewed

Research Projects

II型PI3キナーゼによるメンブレントラフィック制御を介した心臓・血管の機能調節

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2020 - Mar, 2023

安藝翔
New mechanisms of perinatal cardiovascular regulation by class II PI3K

Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists, Grant-in-Aid for Early-Career Scientists, Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2020

Aki Sho
Class II PI3K regulate receptor endocytosis and endosomal signaling

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2018

Aki Sho, Azadul Sarker Kabir, Khin Aung Thuzar
Regulation of membrane trafficking through PI(3)P-metabolizing enzymes in endothelial cells.

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2017

Yoshioka Kazuaki, BISWAS Kuntal, AKI Sho, Kuda Yuichi, MOHRI Hiromi, SHIMIZU Shouta

Profile Information

Research Interests

Research Areas

Research History

Committee Memberships

Awards

Papers

Misc.

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