2009年12月
Ostrich Involvement in the Selection of H5N1 Influenza Virus Possessing Mammalian-Type Amino Acids in the PB2 Protein
JOURNAL OF VIROLOGY
- ,
- ,
- ,
- ,
- ,
- ,
- ,
- 巻
- 83
- 号
- 24
- 開始ページ
- 13015
- 終了ページ
- 13018
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1128/JVI.01714-09
- 出版者・発行元
- AMER SOC MICROBIOLOGY
Amino acids at positions 627 and 701 in the PB2 protein (PB2-627 and PB2-701, respectively) of avian influenza A viruses affect virus replication in some mammalian cells. Highly pathogenic H5N1 influenza viruses possessing mammalian-type PB2-627 were detected during the Qinghai Lake outbreak in 2005 and spread to Europe and Africa. Via a database search, we found a high rate of viral isolates from Ratitae, including ostrich, possessing mammalian-type PB2-627 or -701. Here, we report that H5N1 avian influenza viruses possessing mammalian-type amino acids in PB2-627 or -701 are selected during replication in ostrich cells in vitro and in vivo.
- リンク情報
- ID情報
-
- DOI : 10.1128/JVI.01714-09
- ISSN : 0022-538X
- PubMed ID : 19793811
- Web of Science ID : WOS:000271932900035