Akiko Makino

Profile Information

Affiliation: Kyoto University

Degree: 医学博士(東京大学)

Researcher number: 30571145
J-GLOBAL ID: 201101063743556575
researchmap Member ID: B000001789

Research Areas

Life sciences / Virology /

Research History

Apr, 2022 - Present

准教授, 京都大学医生物学研究所
Mar, 2018 - Present

京都大学ウイルス・再生医科学研究所
Nov, 2012 - Feb, 2018

特定助教, 京都大学ウイルス・再生医科学研究所
Apr, 2012 - Nov, 2012

Institute for Virus Research, Kyoto University
Apr, 2009 - Mar, 2012

Graduate School of Medicine, Kobe University
Apr, 2006 - Mar, 2009

特別研究員DC1, 日本学術振興会

Education

Apr, 2005 - Mar, 2009

The University of Tokyo
Apr, 1998 - Mar, 2005

The University of Tokyo

Papers

Reverse genetics of parrot bornavirus 4 reveals a unique splicing of the glycoprotein gene that affects viral propagation

Ryo Komorizono, Kan Fujino, Susanne Kessler, Solveig Runge, Takehiro Kanda, Masayuki Horie, Akiko Makino, Dennis Rubbenstroth, Keizo Tomonaga

Journal of Virology, 97(8), Aug 31, 2023
Contact-number-driven virus evolution: A multi-level modeling framework for the evolution of acute or persistent RNA virus infection

Junya Sunagawa, Ryo Komorizono, Hyeongki Park, William S. Hart, Robin N. Thompson, Akiko Makino, Keizo Tomonaga, Shingo Iwami, Ryo Yamaguchi

PLOS Computational Biology, 19(5) e1011173-e1011173, May 30, 2023
Efficacy of oligodendrocyte precursor cells as delivery vehicles for single-chain variable fragment to misfolded SOD1 in ALS rat model

Sumio Minamiyama, Madoka Sakai, Yuko Yamaguchi, Makiko Kusui, Hideki Wada, Ryota Hikiami, Yoshitaka Tamaki, Megumi Asada-Utsugi, Akemi Shodai, Akiko Makino …

Molecular Therapy - Methods and Clinical Development, 28 312-329, Mar 9, 2023
Genome-scale CRISPR‒Cas9 screen identifies novel host factors as potential therapeutic targets for SARS-CoV-2 infection

Madoka Sakai, Yoshie Masuda, Yusuke Tarumoto, Naoyuki Aihara, Yugo Tsunoda, Michiko Iwata, Yumiko Kamiya, Ryo Komorizono, Takeshi Noda, Kosuke Yusa …

Mar 7, 2023
A multicenter study to investigate the positive rate of SARS-CoV-2 in middle ear and mastoid specimens from otologic surgery patients.

Hiroshi Yamazaki, Norio Yamamoto, Toru Sonoyama, Hayato Maruoka, Seiko Nasu, Akiko Makino, Keizo Tomonaga, Norifumi Shigemoto, Hiroki Ohge, Keizo Fujiwara …

Auris, nasus, larynx, Jul 29, 2022
Exogenous expression of both matrix protein and glycoprotein facilitates infectious viral particle production of Borna disease virus 1

Takehiro Kanda, Madoka Sakai, Akiko Makino, Keizo Tomonaga

Journal of General Virology, 103(7), Jul 12, 2022
Stability of Borna disease virus‐based episomal vector under physical and chemical stimulation

Mako Yanai, Madoka Sakai, Ryo Komorizono, Akiko Makino, Keizo Tomonaga

Microbiology and Immunology, 66(1) 24-30, Jan, 2022 Peer-reviewedCorresponding author
BUD23-TRMT112 interacts with the L protein of Borna disease virus and mediates the chromosomal tethering of viral ribonucleoproteins.

Bea Clarise B Garcia, Masayuki Horie, Shohei Kojima, Akiko Makino, Keizo Tomonaga

Microbiology and immunology, Jul 29, 2021
A Human Endogenous Bornavirus-Like Nucleoprotein Encodes a Mitochondrial Protein Associated with Cell Viability

Kan Fujino, Masayuki Horie, Shohei Kojima, Sae Shimizu, Aya Nabekura, Hiroko Kobayashi, Akiko Makino, Tomoyuki Honda, Keizo Tomonaga

Journal of Virology, 95(14) e0203020, Jun 24, 2021
Radioligand Assay-Based Detection of Antibodies against SARS-CoV-2 in Hospital Workers Treating Patients with Severe COVID-19 in Japan

Hidenori Matsunaga, Akiko Makino, Yasuhiro Kato, Teruaki Murakami, Yuta Yamaguchi, Atsushi Kumanogoh, Yuichiro Oba, Satoshi Fujimi, Tomoyuki Honda, Keizo Tomonaga

Viruses, 13(2) 347-347, Feb 23, 2021
Optimal Expression of the Envelope Glycoprotein of Orthobornaviruses Determines the Production of Mature Virus Particles

Madoka Sakai, Yoko Fujita, Ryo Komorizono, Takehiro Kanda, Yumiko Komatsu, Takeshi Noda, Keizo Tomonaga, Akiko Makino

Journal of Virology, 95(5), Feb 10, 2021 Last authorCorresponding author
Evolutionary Selection of the Nuclear Localization Signal in the Viral Nucleoprotein Leads to Host Adaptation of the Genus Orthobornavirus

Ryo Komorizono, Yukiko Sassa, Masayuki Horie, Akiko Makino, Keizo Tomonaga

Viruses, 12(11) 1291-1291, Nov 11, 2020 Corresponding author
ADAR2 Is Involved in Self and Nonself Recognition of Borna Disease Virus Genomic RNA in the Nucleus.

Mako Yanai, Shohei Kojima, Madoka Sakai, Ryo Komorizono, Keizo Tomonaga, Akiko Makino

Journal of virology, 94(6), Feb 28, 2020 Peer-reviewed
Development of a reverse transcription-loop-mediated isothermal amplification assay for the detection of parrot bornavirus 4.

Komorizono R, Tomonaga K, Makino A

J Virol Methods, 275 113749, 2020 Peer-reviewed
RNA Virus-Based Episomal Vector with a Fail-Safe Switch Facilitating Efficient Genetic Modification and Differentiation of iPSCs.

Yumiko Komatsu, Dan Takeuchi, Tomoya Tokunaga, Hidetoshi Sakurai, Akiko Makino, Tomoyuki Honda, Yasuhiro Ikeda, Keizo Tomonaga

Molecular therapy. Methods & clinical development, 14 47-55, Sep 13, 2019 Peer-reviewed
Intracellular dynamics of actin affects Borna disease virus replication in the nucleus.

Hirai Y, Domae E, Yoshikawa Y, Okamura H, Makino A, Tomonaga K

Virus research, 263 179-183, Apr, 2019 Peer-reviewed
外来蛋白質を持続発現するボルナウイルスベクターの新たなアルツハイマー病治療戦略

上田紗希帆, 酒井まどか, 大東卓史, 浅田めぐみ, 小松弓子, 眞木崇州, 葛谷聡, 木下彩栄, 高橋良輔, 牧野晶子 …

Dementia Japan, 32(3) 443-443, Sep, 2018
Degradation of amyloid β peptide by neprilysin expressed from Borna disease virus vector

Sakai, M, Ueda, S, Daito, T, Asada-Utsugi, M, Komatsu, Y, Kinoshita, A, Maki, T, Kuzuya, A, Takahashi, R, Makino, A …

Microbiol Immunol, May, 2018 Peer-reviewed
Generation of a non-transmissive Borna disease virus vector lacking both matrix and glycoprotein genes

Kan Fujino, Yusuke Yamamoto, Takuji Daito, Akiko Makino, Tomoyuki Honda, Keizo Tomonaga

MICROBIOLOGY AND IMMUNOLOGY, 61(9) 380-386, Sep, 2017 Peer-reviewed
Dual function of the nuclear export signal of the Borna disease virus nucleoprotein in nuclear export activity and binding to viral phosphoprotein

Mako Yanai, Madoka Sakai, Akiko Makino, Keizo Tomonaga

VIROLOGY JOURNAL, 14 126, Jul, 2017 Peer-reviewed

Misc.

ゲノムワイドCRISPRスクリーニングによるボルナウイルスの転写・複製・持続感染に関わる宿主因子の探索

松郷宙倫, 遊佐宏介, 牧野晶子, 朝長啓造, 松郷宙倫, 牧野晶子, 朝長啓造, 朝長啓造

日本獣医学会学術集会講演要旨集, 166th, 2023
オウム目におけるトリボルナウイルス感染症の病理学的検索

藤原千夏, 相原尚之, 小森園亮, 牧野晶子, 朝長啓造, 曽我玲子, 上家潤一

日本獣医学会学術集会講演要旨集, 162nd, 2019
鳥ボルナウイルスParrot bornavirus4のリバースジェネティクス法の確立

小森園亮, 小森園亮, 藤野寛, 堀江真行, 堀江真行, KESSLER Susanne, RUNGE Solveig, 神田雄大, 神田雄大, 牧野晶子 …

日本ウイルス学会学術集会プログラム・予稿集(Web), 67th, 2019
日本国内の愛玩鳥繁殖場における鳥ボルナウイルス感染症の流行

小森園亮, 小森園亮, 竹前喜洋, 上家潤一, 曽我玲子, 牧野晶子, 牧野晶子, 朝長啓造, 朝長啓造

日本獣医学会学術集会講演要旨集, 161st, 2018
Development of Borna Disease Virus Vector for Differentiation of Human iPSCs into Skeletal Muscle Cells

Yumiko Komatsu, Dan Takeuchi, Hidetoshi Sakurai, Yasuhiro Ikeda, Yusuke Yamamoto, Tomoyuki Honda, Akiko Makino, Keizo Tomonaga

MOLECULAR THERAPY, 25(5) 213-213, May, 2017
Improvement of the production of Borna disease virus vector

A. Makino, R. Komorizono, M. Sakai, K. Tomonaga

HUMAN GENE THERAPY, 27(11) A184-A185, Nov, 2016
A novel intranuclear RNA vector system for long-term stem cell modification

Y. Ikeda, A. Makino, W. E. Matchett, S. J. Holditch, B. Lu, A. B. Dietz, K. Tomonaga

GENE THERAPY, 23(3) 256-262, Mar, 2016 Peer-reviewed
A novel intranuclear RNA vector system for long-term stem cell modification

Y. Ikeda, A. Makino, W. E. Matchett, S. J. Holditch, B. Lu, A. B. Dietz, K. Tomonaga

GENE THERAPY, 23(3) 256-262, Mar, 2016 Peer-reviewed
A novel RNA virus-based episomal vector system for long-term stem cell modification

A. Makino, R. Komorizono, S. J. Holditch, B. Lu, T. Honda, Y. Ikeda, K. Tomonaga

HUMAN GENE THERAPY, 26(10) A26-A27, Oct, 2015
A novel RNA virus vector system for small RNA deliery based on Borna disease virus

T. Honda, Y. Yamamoto, Y. Matsumoto, A. Makino, K. Tomonaga

HUMAN GENE THERAPY, 26(10) A102-A102, Oct, 2015
The regulation of Borna disease virus production

Akiko Makino, Tomoyuki Honda, Keizo Tomonaga

The 14th Awaji International Forum on Infection and Immunity, Sep, 2015 Peer-reviewed
IGF2 is involved in the regulation of Borna disease virus production.

Akiko Makino, Tomoyuki Honda, Keizo Tomonaga

Negative Strand RNA virus meeting 2015, Jun, 2015 Peer-reviewed
IGF2によるボルナ病ウイルス粒子産生制御機構の解析

牧野晶子, 藤野寛, 平井悠哉, 本田知之, 朝長啓造

第8回日本ボルナウイルス研究会, Mar, 2015 Peer-reviewed
IGF2によるボルナ病ウイルス粒子産生制御機構の解析

牧野晶子, 藤野寛, 平井悠哉, 惣福梢, 本田知之, 朝長啓造

第4回Negative Strand Virus-Japan, Jan, 2015 Peer-reviewed
ボルナ病ウイルス粒子産生に対する宿主因子IGF2の関与

牧野晶子, 藤野寛, 平井悠哉, 惣福梢, 本田知之, 朝長啓造

第62回日本ウイルス学会, Nov, 2014 Peer-reviewed
ハダカデバネズミのゲノムに内在化したレトロウイルス様配列の解析

牧野晶子, 宮沢孝幸, 鈴木善幸, 三浦恭子, 朝長啓造

第157回日本獣医学会学術集会, -akkmkn, Sep, 2014 Peer-reviewed
Expression of IGF2 affects Borna disease virus production in infected cells

Akiko Makino, Kan Fujino, Takuji Daito, Tomoyuki Honda, Keizo Tomonaga

International Union of Microbiological Societies Congresses, Jul, 2014 Peer-reviewed
ボルナウイルスの粒子産生制御機構の解析

牧野晶子, 藤野寛, 大東卓史, 本田知之, 朝長啓造

第3回Negative Strand Virus-Japan, Jan, 2014 Peer-reviewed
ボルナ病ウイルスNタンパク質のアンキリン様配列を介したNF-κ B活性化阻害

牧野晶子, 藤野寛, 惣福梢, 中村祥子, 本田知之, 朝長啓造

第61回日本ウイルス学会, 61st, Nov, 2013 Peer-reviewed
Inhibition of NF-κB activation by peptide derived from nucleoprotein of Borna disease virus.

Akiko Makino, Kan Fujino, Kozue Sofuku, Shoko Nakamura, Tomoyuki Honda, Keizo Tomonaga

15th International Negative Strand Virus Meeting, Jun, 2013 Peer-reviewed

Presentations

Development of borna disease virus vector system.

Akiko Makino

Special seminar at Mayo clinic, Jul 24, 2014 Invited

Research Projects

エマージングリスクであるボルナ病ウイルスの制御法確立

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2021 - Mar, 2024

牧野晶子
ボルナウイルスの核内持続感染が解き明かすウイルス進化戦略の多様性

科学研究費助成事業, 新学術領域研究(研究領域提案型), 日本学術振興会, Apr, 2019 - Mar, 2021

牧野晶子
Risk assessment and pathogenicity of highly pathogenic emerging bornavirus

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2021

Makino Akiko
Generation of episomal RNA viral vector for stem cell gene therapy

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2018

Makino Akiko

Profile Information

Research Areas

Research History

Education

Papers

Misc.

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