2011年7月
Glucosylceramide synthase in the fat body controls energy metabolism in Drosophila
JOURNAL OF LIPID RESEARCH
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- ,
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- 巻
- 52
- 号
- 7
- 開始ページ
- 1392
- 終了ページ
- 1399
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1194/jlr.M014266
- 出版者・発行元
- AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
Glucosylceramide synthase (GlcT-1) catalyzes the synthesis of glucosylceramide (GlcCer), the core structure of major glycosphingolipids (GSLs). Obesity is a metabolic disorder caused by an imbalance between energy uptake and expenditure, resulting in excess stored body fat. Recent studies have shown that GSL levels are increased in obese rodents and that pharmacologically reducing GSL levels by inhibiting GlcCer synthesis improves adipocyte function. However, the molecular mechanism underlying these processes is still not clearly understood. Using Drosophila as a model animal, we report that GlcT-1 expression in the fat body, which is equivalent to mammalian adipose tissue, regulates energy metabolism. Overexpression of GlcT-1 increases stored nutrition (triacylglycerol and carbohydrate) levels. Conversely, reduced expression of GlcT-1 in the fat body causes a reduction of fat storage. This regulation occurs, at least in part, through the activation of p38-ATF2 signaling. Furthermore, we found that GlcCer is the sole GSL of the fat body, indicating that regulation of GlcCer synthesis by GlcT-1 in the fat body is responsible for regulating energy homeostasis. Both GlcT-1 and p38-ATF2 signaling are evolutionarily conserved, leading us to propose an evolutionary perspective in which GlcT-1 appears to be one of the key factors that control fat metabolism.-Kohyama-Koganeya, A., T. Nabetani, M. Miura, and Y. Hirabayashi. Glucosylceramide synthase in the fat body controls energy metabolism in Drosophila. J. Lipid Res. 2011. 52: 1392-1399.
- リンク情報
- ID情報
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- DOI : 10.1194/jlr.M014266
- ISSN : 0022-2275
- PubMed ID : 21550991
- Web of Science ID : WOS:000291466400010