オードリッチコートーニー (Courtney Aldrich) - マイポータル

基本情報

所属: University of Minnesota Medicinal Chemistry Professor

学位: Ph.D. in Chemistry(2001年1月 University of California, Los Angeles)

J-GLOBAL ID: 202101008893522713
researchmap会員ID: R000029669

学歴

1995年9月 - 2001年1月

UCLA, Chemistry, Ph.D. Thesis Title: Synthesis of Calphostin C and Related Perlyenequinone Analogs Utilizing Chromium Carbene Complexes

論文

Cephem-Pyrazinoic Acid Conjugates: Circumventing Resistance in Mycobacterium tuberculosis.

Malcolm S Cole, Michael D Howe, Joseph A Buonomo, Sachin Sharma, Elise A Lamont, Scott I Brody, Neeraj K Mishra, Yusuke Minato, Joshua M Thiede, Anthony D Baughn …

Chemistry (Weinheim an der Bergstrasse, Germany) 2022年6月13日
Blocking Bacterial Naphthohydroquinone Oxidation and ADP-Ribosylation Improves Activity of Rifamycins against Mycobacterium abscessus.

Uday S Ganapathy, Tian Lan, Philipp Krastel, Marissa Lindman, Matthew D Zimmerman, HsinPin Ho, Jansy P Sarathy, Joanna C Evans, Véronique Dartois, Courtney C Aldrich …

Antimicrobial agents and chemotherapy 65(9) e0097821 2021年8月17日
Mycobacterium tuberculosis PanD Structure-Function Analysis and Identification of a Potent Pyrazinoic Acid-Derived Enzyme Inhibitor.

Priya Ragunathan, Malcolm Cole, Chitra Latka, Wassihun Wedajo Aragaw, Pooja Hegde, Joon Shin, Malathy Sony Subramanian Manimekalai, Sankaranarayanan Rishikesan, Courtney C Aldrich, Thomas Dick …

ACS chemical biology 16(6) 1030-1039 2021年6月18日
8-cyanobenzothiazinone analogs with potent antitubercular activity.

Gang Zhang, Li Sheng, Pooja Hegde, Yan Li, Courtney C Aldrich

Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents 1-10 2021年1月13日
Development of small-molecule inhibitors of fatty acyl-AMP and fatty acyl-CoA ligases in Mycobacterium tuberculosis.

Marzena Baran, Kimberly D Grimes, Paul A Sibbald, Peng Fu, Helena I M Boshoff, Daniel J Wilson, Courtney C Aldrich

European journal of medicinal chemistry 201 112408-112408 2020年9月1日
Design, Synthesis, and Biophysical Evaluation of Mechanism-Based Probes for Condensation Domains of Nonribosomal Peptide Synthetases.

Ce Shi, Bradley R Miller, Evan M Alexander, Andrew M Gulick, Courtney C Aldrich

ACS chemical biology 15(7) 1813-1819 2020年7月17日
Biosynthesis, Mechanism of Action, and Inhibition of the Enterotoxin Tilimycin Produced by the Opportunistic Pathogen Klebsiella oxytoca.

Evan M Alexander, Dale F Kreitler, Valeria Guidolin, Alexander K Hurben, Eric Drake, Peter W Villalta, Silvia Balbo, Andrew M Gulick, Courtney C Aldrich

ACS infectious diseases 6(7) 1976-1997 2020年7月10日
The Biotin Biosynthetic Pathway in Mycobacterium tuberculosis is a Validated Target for the Development of Antibacterial Agents.

Matthew R Bockman, Neeraj Mishra, Courtney C Aldrich

Current medicinal chemistry 27(25) 4194-4232 2020年
Noncompetitive inhibitors of TNFR1 probe conformational activation states.

Chih Hung Lo, Tory M Schaaf, Benjamin D Grant, Colin Kin-Wye Lim, Prachi Bawaskar, Courtney C Aldrich, David D Thomas, Jonathan N Sachs

Science signaling 12(592) 2019年7月30日
Investigation of ( S)-(-)-Acidomycin: A Selective Antimycobacterial Natural Product That Inhibits Biotin Synthase.

Matthew R Bockman, Curtis A Engelhart, Julia D Cramer, Michael D Howe, Neeraj K Mishra, Matthew Zimmerman, Peter Larson, Nadine Alvarez-Cabrera, Sae Woong Park, Helena I M Boshoff …

ACS infectious diseases 5(4) 598-617 2019年4月12日
A Cinchona Alkaloid Antibiotic That Appears To Target ATP Synthase in Streptococcus pneumoniae.

Xu Wang, Yuna Zeng, Li Sheng, Peter Larson, Xue Liu, Xiaowen Zou, Shufang Wang, Kaijing Guo, Chen Ma, Gang Zhang …

Journal of medicinal chemistry 62(5) 2305-2332 2019年3月14日
Spirocyclic and Bicyclic 8-Nitrobenzothiazinones for Tuberculosis with Improved Physicochemical and Pharmacokinetic Properties.

Gang Zhang, Michael Howe, Courtney C Aldrich

ACS medicinal chemistry letters 10(3) 348-351 2019年3月14日
Structural Basis of Polyketide Synthase O-Methylation.

Meredith A Skiba, Marissa M Bivins, John R Schultz, Steffen M Bernard, William D Fiers, Qingyun Dan, Sarang Kulkarni, Peter Wipf, William H Gerwick, David H Sherman …

ACS chemical biology 13(12) 3221-3228 2018年12月21日
Trapping interactions between catalytic domains and carrier proteins of modular biosynthetic enzymes with chemical probes.

Andrew M Gulick, Courtney C Aldrich

Natural product reports 35(11) 1156-1184 2018年11月14日
Avoiding Antibiotic Inactivation in Mycobacterium tuberculosis by Rv3406 through Strategic Nucleoside Modification.

Matthew R Bockman, Curtis A Engelhart, Surendra Dawadi, Peter Larson, Divya Tiwari, David M Ferguson, Dirk Schnappinger, Courtney C Aldrich

ACS infectious diseases 4(7) 1102-1113 2018年7月13日
Structural and functional delineation of aerobactin biosynthesis in hypervirulent Klebsiella pneumoniae.

Daniel C Bailey, Evan Alexander, Matthew R Rice, Eric J Drake, Lisa S Mydy, Courtney C Aldrich, Andrew M Gulick

The Journal of biological chemistry 293(20) 7841-7852 2018年5月18日
Targeting protein biotinylation enhances tuberculosis chemotherapy.

Divya Tiwari, Sae Woong Park, Maram M Essawy, Surendra Dawadi, Alan Mason, Madhumitha Nandakumar, Matthew Zimmerman, Marizel Mina, Hsin Pin Ho, Curtis A Engelhart …

Science translational medicine 10(438) 2018年4月25日
Conformationally Constrained Cinnolinone Nucleoside Analogues as Siderophore Biosynthesis Inhibitors for Tuberculosis.

Surendra Dawadi, Helena I M Boshoff, Sae Woong Park, Dirk Schnappinger, Courtney C Aldrich

ACS medicinal chemistry letters 9(4) 386-391 2018年4月12日
Mutual potentiation drives synergy between trimethoprim and sulfamethoxazole.

Yusuke Minato, Surendra Dawadi, Shannon L Kordus, Abiram Sivanandam, Courtney C Aldrich, Anthony D Baughn

Nature communications 9(1) 1003-1003 2018年3月8日
Whole-Cell Screen of Fragment Library Identifies Gut Microbiota Metabolite Indole Propionic Acid as Antitubercular.

Dereje A Negatu, Joe J J Liu, Matthew Zimmerman, Firat Kaya, Véronique Dartois, Courtney C Aldrich, Martin Gengenbacher, Thomas Dick

Antimicrobial agents and chemotherapy 62(3) 2018年3月

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オードリッチコートーニー

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