Alfarius Eko Nugroho

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アバター
研究者氏名
Alfarius Eko Nugroho
所属
星薬科大学
部署
イノベーションセンター
学位
博士(薬学)(星薬科大学)

研究キーワード

 
 

研究分野

 
 

経歴

 
2012年4月
 - 
2015年3月
星薬科大学
 

学歴

 
2009年4月
 - 
2012年3月
星薬科大学 博士課程  
 

論文

 
Toshio Kaneda, Haruka Yoshida, Yuki Nakajima, Minako Toishi, Alfarius Eko Nugroho, Hiroshi Morita
Bioorganic & medicinal chemistry letters   26(7) 1760-1761   2016年2月   [査読有り]
Hitomi Nishino, Yuki Nakajima, Yoshiaki Kakubari, Nakata Asami, Jun Deguchi, Alfarius Eko Nugroho, Yusuke Hirasawa, Toshio Kaneda, Yoko Kawasaki, Yukihiro Goda, Hiroshi Morita
Bioorganic and Medicinal Chemistry Letters   26 524-525   2016年1月   [査読有り]
© 2015 Elsevier Ltd.All rights reserved. Oxomollugin (2) is a degradation product of mollugin (1) and a potent inhibitor of NO-production including nuclear factor kappa B signals. In our endeavor to develop a potent anti-inflammatory compound, we ...
Chin Piow Wong, Ari Seki, Kaori Horiguchi, Tomokazu Shoji, Takashi Arai, Alfarius Eko Nugroho, Yusuke Hirasawa, Fumiaki Sato, Toshio Kaneda, Hiroshi Morita
Journal of Natural Products   78 1656-1662   2015年7月   [査読有り]
© 2015 The American Chemical Society and American Society of Pharmacognosy. We have previously reported that bisleuconothine A (Bis-A), a novel bisindole alkaloid isolated from Leuconotis griffithii, showed cytostatic activity in several cell line...
Alfarius E. Nugroho, Rio Sugiura, Takanori Momota, Yusuke Hirasawa, Chin Piow Wong, Toshio Kaneda, A. Hamid A Hadi, Hiroshi Morita
Journal of Natural Medicines   69 411-415   2015年7月   [査読有り]
© 2015 The Japanese Society of Pharmacognosy and Springer. Two new aromadendrane sesquiterpenoids, dysosesquiflorins A and B (1 and 2), were isolated from Dysoxylum densiflorum bark, and their structures were elucidated on the basis of NMR spectro...
Hiroshi Morita, Hitomi Nishino, Yuki Nakajima, Yoshiaki Kakubari, Asami Nakata, Jun Deguchi, Alfarius Eko Nugroho, Yusuke Hirasawa, Toshio Kaneda, Yoko Kawasaki, Yukihiro Goda
Journal of Natural Medicines   69 608-611   2015年7月   [査読有り]
© 2015 The Japanese Society of Pharmacognosy and Springer Japan. Mollugin, a naphthoquinone derivative, was reported to possess various biological activities such as anti-inflammatory and anti-tumor activity. Mollugin isolated from Rubia tinctorum...
Azusa Haseo, Alfarius Eko Nugroho, Yusuke Hirasawa, Toshio Kaneda, Osamu Shirota, Abdul Rahman, C. Idha Kusumawati, Noor Cholies Zaini, Hiroshi Morita
Heterocycles   90 601-606   2015年1月   [査読有り]
©2015 The Japan Institute of Heterocyclic Chemistry Received. A new bisindole alkaloid, voacalgine F (1), has been isolated from the bark of Indonesian Voacanga grandifollia (Miq.) Rolfe. Its structure was elucidated on the basis of 1D and 2D-NMR ...
Janar Jenis, Janar Jenis, Alfarius Eko Nugroho, Akiyo Hashimoto, Jun Deguchi, Yusuke Hirasawa, Chin Piow Wong, Toshio Kaneda, Osamu Shirota, Hiroshi Morita
Natural Product Communications   10 291-292   2015年1月   [査読有り]
A new benzylisoquinoline alkaloid, lincangenine-4-β-D-glucopyranoside (1), has been isolated from the roots of Leontice altaica, together with 5 known alkaloids. Its structure was elucidated on the basis of 1D and 2D NMR data, and chemical means.
Alfarius E. Nugroho, Takanori Momota, Rio Sugiura, Marina Hanzawa, Erika Yajima, Yuta Nagakura, Naoki Yasuda, Yusuke Hirasawa, Chin Piow Wong, Toshio Kaneda, A. Hamid A Hadi, Haruhiko Fukaya, Hiroshi Morita
Tetrahedron   70 9661-9667   2014年12月   [査読有り]
© 2014 Elsevier Ltd. Thirteen new triterpenoids, dysotriflorins A-M (1-13), were isolated from Dysoxylum densiflorum barks, and their structures were elucidated on the basis of NMR spectroscopic data and X-ray crystallography. Dysotriflorins A, B,...
Hiroshi Morita, Alfarius Eko Nugroho, Yuta Nagakura, Yusuke Hirasawa, Haruka Yoshida, Toshio Kaneda, Osamu Shirota, Intan Safinar Ismail
Bioorganic and Medicinal Chemistry Letters   24 2437-2439   2014年6月   [査読有り]
Four new chromone alkaloids, chrotacumines G-J (1-4), have been isolated from the barks of Dysoxylum acutangulum. Their structures and absolute configurations were elucidated on the basis of NMR and CD data. Chrotacumines G and J (1 and 4) showed ...
Reika Mori, Alfarius Eko Nugroho, Yusuke Hirasawa, Chin Piow Wong, Toshio Kaneda, Osamu Shirota, A. Hamid A Hadi, Hiroshi Morita
Journal of Natural Medicines   68 186-191   2014年1月   [査読有り]
Three new terpenoids, opaciniols A-C (1-3), were isolated from the barks of Garcinia opaca, together with malabarica-17,21-dien-3β,14-diol (4) and 13βH-malabarica-14,17,21-trien-3β-ol (5). Their structures were determined on the basis of NMR spect...
Yuko Kiren, Alfarius Eko Nugroho, Yusuke Hirasawa, Osamu Shirota, Myrzaim Bekenova, Narbekov Omorbay Narbekovich, Marina Shapilova, Hiromichi Maeno, Hiroshi Morita
Journal of Natural Medicines   68 199-205   2014年1月   [査読有り]
Five new diterpenoids belonging to labdane and isopimarane skeletons, mumic acids A-E (1-5), have been isolated from mumiyo. Their structures and absolute configurations were elucidated on the basis of spectroscopic data and chemical derivatizatio...
Amal Sallam, Amal Sallam, Alfarius Eko Nugroho, Yusuke Hirasawa, Wong Chin-Piow, Toshio Kaneda, Osamu Shirota, Sahar R. Gedara, Hiroshi Morita
Natural Product Communications   9 1243-1244   2014年1月   [査読有り]
© 2014, Natural Product Incorporation. All rights reserved. A new acyclic diterpenoid (1) and a new erythroxan diterpenoid (2), together with 4 erythroxan diterpenoids and 3 triterpenoids, have been isolated from the aerial parts of Fagonia mollis...
Alfarius Eko Nugroho, Hiroshi Morita
Journal of Natural Medicines   68 1-10   2014年1月   [査読有り]
Determination of the absolute configuration (AC) is often a challenging aspect in the structure elucidation of natural products. When chiral compounds possess appropriate chromophore(s), electronic circular dichroism (ECD) may provide a powerful a...
Alfarius E. Nugroho, Maho Okuda, Yukari Yamamoto, Yusuke Hirasawa, Chin Piow Wong, Toshio Kaneda, Osamu Shirota, A. Hamid A Hadi, Hiroshi Morita
Tetrahedron   69 4139-4145   2013年5月   [査読有り]
Six new limonoids, Walsogynes B (1)-G (6), were isolated from the barks of Walsura chrysogyne, and their structures were determined on the basis of NMR and MS spectroscopic analyses in combination with NMR chemical shifts calculations. Walsogynes ...
Yuta Nagakura, Alfarius Eko Nugroho, Yusuke Hirasawa, Takahiro Hosoya, Abdul Rahman, Idha Kusumawati, Noor Cholies Zaini, Hiroshi Morita
Journal of Natural Medicines   67 381-385   2013年4月   [査読有り]
Two new limonoids, sanjecumins A (1) and B (2), have been isolated from the leaves of Sandoricum koetjape, together with sandoripins A (3) and B (4). Their structures and absolute configurations were elucidated on the basis of NMR and CD data. San...
Chin Piow Wong, Jun Deguchi, Alfarius Eko Nugroho, Toshio Kaneda, A. Hamid A Hadi, Hiroshi Morita
Bioorganic and Medicinal Chemistry Letters   23 1786-1788   2013年3月   [査読有り]
In our search for lipid-droplets accumulation (LDA) inhibitors, some ceramicines, a series of limonoids isolated from the barks of Chisocheton ceramicus, were discovered to be active as anti-LDA. Preliminary structure-activity relationships (SAR) ...
Fumie Yamasaki, Shoko Machida, Asami Nakata, Alfarius Eko Nugroho, Yusuke Hirasawa, Toshio Kaneda, Osamu Shirota, Naoyuki Hagane, Tadayoshi Sugizaki, Hiroshi Morita
Journal of Natural Medicines   67 212-216   2013年1月   [査読有り]
Two new isocoumarin glucosides, haworforbins A (1) and B (2), and a new chromone, haworforbin C (3), have been isolated from Haworthia cymbiformis. Their structures and absolute configurations were elucidated on the basis of NMR and CD data. Hawor...
Kartini Ahmad, Kartini Ahmad, Yusuke Hirasawa, Alfarius Eko Nugroho, A. Hamid A Hadi, Hiroshi Morita
Heterocycles   86 1611-1619   2012年12月   [査読有り]
Three new aspidofractinines; N(1)-formylkopsininic acid (1), N(1)-formylkopsininic acid-N(4)-oxide (2), 15-hydroxykopsamine (3), a new aspidospermatan; 14α-hydroxy-N(4)-methylcondylocarpine (4) and a new akuamiline; singaporentinidine (5) type ind...
Chin Piow Wong, Misae Shimada, Alfarius Eko Nugroho, Yusuke Hirasawa, Toshio Kaneda, A. Hamid A Hadi, Shirota Osamu, Hiroshi Morita
Journal of Natural Medicines   66 566-570   2012年7月   [査読有り]
Three new limonoids, ceramicines J (1), K (2), and L (3), were isolated from the hexane layer of Chisocheton ceramicus bark extract. Their structures were elucidated from 1D and 2D NMR data. Ceramicines J-L (1-3) exhibited dose-dependent moderate ...
Alfarius E. Nugroho, Yusuke Hirasawa, Wong Chin Piow, Toshio Kaneda, A. Hamid A Hadi, Osamu Shirota, Wiwied Ekasari, Aty Widyawaruyanti, Hiroshi Morita
Journal of Natural Medicines   66 350-353   2012年4月   [査読有り]
A new indole alkaloid, leucoridine A N-oxide (1), consisting of two units of a strychnan type of skeleton, was isolated from the leaves of Leuconotis griffithii. Its structure was elucidated by various spectroscopic means such as NMR and MS, and a...
Midori Motegi, Alfarius Eko Nugroho, Yusuke Hirasawa, Takashi Arai, A. Hamid A Hadi, Hiroshi Morita
Tetrahedron Letters   53 1227-1230   2012年3月   [査読有り]
Two novel indole alkaloids and new quinazoline alkaloids, namely leucomidines A-C (1-3), were isolated from the barks of Leuconotis griffithii. The structures including the absolute configuration were elucidated on the basis of spectroscopic data,...
Fei He, Fei He, Alfarius Eko Nugroho, Chin Piow Wong, Yusuke Hirasawa, Osamu Shirota, Hiroshi Morita, Haji Akber Aisa
Chemical and Pharmaceutical Bulletin   60 213-218   2012年2月   [査読有り]
Eight new guaipyridine sesquiterpene alkaloids, rupestines F-M (1-8) were isolated from the leaves of Artemisia rupestris and their structures were elucidated on the basis of 2D-NMR data. The absolute configurations of 1-8 have been assigned by co...
Jenis Janar, Jenis Janar, Alfarius Eko Nugroho, Yusuke Hirasawa, Bahargul Konirhan, Hiroshi Morita
Heterocycles   84 1259-1263   2012年2月   [査読有り]
Two new lignans, sabinaperins A (1) and B (2), have been isolated from the aerial part of Juniperus sabina L. together with six known lignans. Their structures were established on the basis of 1D and 2D-NMR data analysis. © 2012 The Japan Institut...
Ibrahim A. Najmuldeen, A. Hamid A Hadi, Khalit Mohamad, Khalijah Awang, Kamal Aziz Ketuly, Mat Ropi Mukhtar, Hairin Taha, Noraziah Nordin, Marc Litaudon, Françoise Guéritte, Alfarius Eko Nugroho, Hiroshi Morita
Heterocycles   84 1265-1270   2012年2月   [査読有り]
Two new limonoids, chisomicines D and E (1 - 2) have been isolated from the bark of Malaysian Chisocheton ceramicus (Miq.) C. DC. Their structures were elucidated on the basis of 1D and 2D-NMR data analysis. © 2012 The Japan Institute of Heterocyc...
Koichiro Koyama, Yusuke Hirasawa, Alfarius E. Nugroho, Toshio Kaneda, Teh Chin Hoe, Kit Lam Chan, Hiroshi Morita
Tetrahedron   68 1502-1506   2012年2月   [査読有り]
Three novel indole alkaloids, alsmaphorazines C (1)-E (3), were isolated from the leaves of Alstonia pneumatophora (Apocynaceae) and their structures were determined on the basis of the 2D NMR and MS spectral analyses. The absolute configurations ...
Jenis Janar, Jenis Janar, Alfarius Eko Nugroho, Chin Piow Wong, Yusuke Hirasawa, Toshio Kaneda, Osamu Shirota, Hiroshi Morita
Chemical and Pharmaceutical Bulletin   60 154-159   2012年1月   [査読有り]
Six new diterpenoids, sabiperones A - F (1-6) have been isolated from the aerial part of Juniperus sabina. Their structures were elucidated by spectroscopic methods including 2D NMR techniques. Sabiperone F showed moderate cell growth inhibitory a...
Alfarius Eko Nugroho, Hiroshi Morita
Heterocycles   84 101-113   2011年12月   [査読有り]
Monoterpene indole alkaloids comprise a group of naturally occurring compounds, exhibiting a range of biological activities. These compounds have attracted great attention because of their interesting biosynthetic route and also as a challenging t...
Hairin Taha, A. Hamid A Hadi, Noraziah Nordin, Ibrahim A. Najmuldeen, Khalit Mohamad, Osamu Shirota, Alfarius E. Nugroho, Wong Chin Piow, Toshio Kaneda, Hiroshi Morita
Chemical and Pharmaceutical Bulletin   59 896-897   2011年7月   [査読有り]
Pseuduvarines A (1) and B (2), two new dioxoaporphine alkaloids with an amino moiety, were isolated from the stem bark of Pseuduvaria rugosa and their structures were elucidated by combination of 2D-NMR spectroscopic analysis. Pseuduvarines A (1) ...
Alfarius E. Nugroho, Masatomo Sugai, Yusuke Hirasawa, Takahiro Hosoya, Khalijah Awang, A. Hamid A Hadi, Wiwied Ekasari, Aty Widyawaruyanti, Hiroshi Morita
Bioorganic and Medicinal Chemistry Letters   21 3417-3419   2011年6月   [査読有り]
Two new indole alkaloids, bisnicalaterine D (1), consisting of an eburnane and a corynanthe type of skeletons, and nicalaterine A (2) were isolated from the bark of Hunteria zeylanica. Their structures were elucidated by various spectroscopic data...
Ibrahim A. Najmuldeen, A. Hamid A Hadi, Khalijah Awang, Khalit Mohamad, Kamal Aziz Ketuly, Mat Ropi Mukhtar, Soon Lim Chong, Gomathi Chan, Mohd Azlan Nafiah, Ng Seik Weng, Osamu Shirota, Takahiro Hosoya, Alfarius E. Nugroho, Hiroshi Morita
Journal of Natural Products   74 1313-1317   2011年5月   [査読有り]
Three new limonoids, chisomicines A-C (1-3), have been isolated from the bark of Chisocheton ceramicus. Their structures were determined by 2D NMR, CD spectroscopic methods, and X-ray analysis. Chisomicine A (1) exhibited NO production inhibitory ...
Chin Piow Wong, Misae Shimada, Yuta Nagakura, Alfarius Eko Nugroho, Yusuke Hirasawa, Toshio Kaneda, Khalijah Awang, A. Hamid A Hadi, Khalit Mohamad, Motoo Shiro, Hiroshi Morita
Chemical and Pharmaceutical Bulletin   59 407-411   2011年3月   [査読有り]
Five new limonoids, ceramicines E-I (1-5), have been isolated from the bark of Chisocheton ceramicus. The structures and relative stereochemistry of them were fully elucidated based on 1D- and 2D-NMR data. Ceramicines E-I (1-5) exhibited moderate ...
Ahmad Kaleem Qureshi, Mat Ropi Mukhtar, Yusuke Hirasawa, Takahiro Hosoya, Alfarius Eko Nugroho, Hiroshi Morita, Osamu Shirota, Khalit Mohamad, A. Hamid A Hadi, Marc Litaudon, Khalijah Awang
Chemical and Pharmaceutical Bulletin   59 291-293   2011年2月   [査読有り]
Two new indole alkaloids, neolamarckines A and B (1, 2) were isolated from the leaves of Neolamarckia cadamba (Rubiaceae). Structural elucidation of 1 and 2 was performed by combination of 2D-NMR and circular dichroism (CD) spectra, and chemical c...
Yongqiang Liu, Yongqiang Liu, Alfarius E. Nugroho, Yusuke Hirasawa, Asami Nakata, Toshio Kaneda, Nahoko Uchiyama, Yukihiro Goda, Osamu Shirota, Hiroshi Morita, Haji Akber Aisa
Tetrahedron Letters   51 6584-6587   2010年12月   [査読有り]
Two novel elemanolide dimers, vernodalidimers A (1) and B (2), possessing a rare tricyclic ortho ester moiety, were isolated from the seeds of Vernonia anthelmintica. Their structures were elucidated by ID and 2D NMR data and CD spectra. Vernodali...
Jun Deguchi, Tomokazu Shoji, Alfarius E. Nugroho, Yusuke Hirasawa, Takahiro Hosoya, Osamu Shirota, Khalijah Awang, A. Hamid A Hadi, Hiroshi Morita
Journal of Natural Products   73 1727-1729   2010年10月   [査読有り]
Eucophylline (1), a new tetracyclic vinylquinoline alkaloid, was isolated from the bark of Leuconotis eugenifolius together with leucophyllidine (2). The structure and absolute configuration of 1 were elucidated on the basis of 2D NMR correlations...
Koichiro Koyama, Yusuke Hirasawa, Alfarius Eko Nugroho, Takahiro Hosoya, Teh Chin Hoe, Kit Lam Chan, Hiroshi Morita
Organic Letters   12 4188-4191   2010年9月   [査読有り]
Two novel indole alkaloids, alsmaphorazines A and B, were isolated from the leaves of Alstonia pneumatophora (Apocynaceae), and their structures were determined on the basis of the 2D NMR and MS spectral analysis. These alkaloids possessed a new s...
Yusuke Hirasawa, Mayumi Hara, Alfarius E. Nugroho, Masatomo Sugai, Kazumasa Zaima, Nobuo Kawahara, Yukihiro Goda, Khalijah Awang, A. Hamid A Hadi, Marc Litaudon, Hiroshi Morita
Journal of Organic Chemistry   75 4218-4223   2010年6月   [査読有り]
Two new bisindole alkaloids, bisnicalaterines B and C (1 and 2) consisting of an eburnane and a corynanthe type of skeletons, were isolated from the bark of Hunteria zeylanica. Their absolute structures were determined by combination of NMR, CD, a...
Alfarius E. Nugroho, Yusuke Hirasawa, Takahiro Hosoya, Khalijah Awang, A. Hamid A Hadi, Hiroshi Morita
Tetrahedron Letters   51 2589-2592   2010年5月   [査読有り]
A novel bisindole alkaloid, bisleucocurine A (1), consisting of two strychnan skeletons with an N-1-C-17′ and a C-12-C-2′ bridges, was isolated from the leaves of Leuconotis griffithii and the structure was elucidated on the basis of spectroscopic...
Yusuke Hirasawa, Tomokazu Shoji, Takashi Arai, Alfarius E. Nugroho, Jun Deguchi, Takahiro Hosoya, Nahoko Uchiyama, Yukihiro Goda, Khalijah Awang, A. Hamid A Hadi, Motoo Shiro, Hiroshi Morita
Bioorganic and Medicinal Chemistry Letters   20 2021-2024   2010年3月   [査読有り]
A new bisindole alkaloid, bisleuconothine A (1) consisting of an eburnane-aspidosperma type skeleton, was isolated from the bark of Leuconotis griffithii. The structure including absolute stereochemistry was elucidated on the basis of 2D NMR data ...
Alfarius E. Nugroho, Yusuke Hirasawa, Nobuo Kawahara, Yukihiro Goda, Khalijah Awang, A. Hamid A Hadi, Hiroshi Morita
Journal of Natural Products   72 1502-1506   2009年8月   [査読有り]
A new bisindole alkaloid, bisnicalaterine A (1), consisting of two vobasine-type skeletons, and 3-epivobasinol (2) and 3-O-methylepivobasinol (3), with vobasine-type skeletons, were isolated from the leaves of Hunteria zeylanica, and their structu...