Hanamatsu Hisatoshi

Profile Information

Affiliation: Nagoya University

Degree: Doctor of Life science(Hokkaido University)

J-GLOBAL ID: 201401062250173745
researchmap Member ID: B000241804

Research Interests

Research Areas

Life sciences / Molecular biology /

Awards

Oct, 2021

第２４回日本糖質学会奨励賞, シアル酸結合様式特異的な化学修飾による構造異性体識別法の開発, 日本糖質学会

花松久寿

Papers

Articular cartilage corefucosylation regulates tissue resilience in osteoarthritis.

Kentaro Homan, Tomohiro Onodera, Hisatoshi Hanamatsu, Jun-Ichi Furukawa, Daisuke Momma, Masatake Matsuoka, Norimasa Iwasaki

eLife, 12, Mar 11, 2024
Tolerable glycometabolic stress boosts cancer cell resilience through altered N-glycosylation and Notch signaling activation.

Shungo Iwamoto, Takashi Kobayashi, Hisatoshi Hanamatsu, Ikuko Yokota, Yukiko Teranishi, Akiho Iwamoto, Miyu Kitagawa, Sawako Ashida, Ayane Sakurai, Suguru Matsuo …

Cell death & disease, 15(1) 53-53, Jan 15, 2024
Focal-adhesion kinase regulates the sialylation of N-glycans via the PI4KIIα-PI4P pathway.

Yuhan Sun, Tomoya Isaji, Yoshiyuki Oyama, Xing Xu, Jianwei Liu, Hisatoshi Hanamatsu, Ikuko Yokota, Nobuaki Miura, Jun-Ichi Furukawa, Tomohiko Fukuda …

The Journal of biological chemistry, 105051-105051, Jul 12, 2023
Simultaneous and sialic acid linkage-specific N- and O-linked glycan analysis by ester-to-amide derivatization.

Hisatoshi Hanamatsu, Yoshiaki Miura, Takashi Nishikaze, Ikuko Yokota, Kentaro Homan, Tomohiro Onodera, Yoshihiro Hayakawa, Norimasa Iwasaki, Jun-Ichi Furukawa

Glycoconjugate journal, 40(2) 259-267, Apr, 2023 Peer-reviewed
Exposure to brefeldin A induces unusual expression of hybrid- and complex-type free N-glycans in HepG2 cells

Kanako Sugiura, Yuho Kawai, Arisa Yamamoto, Hiroki Yoshioka, Yuika Kiyohara, Ayaka Iida, Yurika Ozawa, Mai Nishikawa, Nobuaki Miura, Hisatoshi Hanamatsu …

Biochimica et Biophysica Acta (BBA) - General Subjects, 130331-130331, Feb, 2023 Peer-reviewed
Comprehensive Glycan Analysis of Sphingolipids in Human Serum/Plasma.

Hisatoshi Hanamatsu, Takashi Nishikaze, Jun-Ichi Furukawa

Methods in molecular biology (Clifton, N.J.), 2613 289-299, 2023
Simultaneous determination of heparan sulfate, chondroitin/dermatan sulfates, and hyaluronan glycosaminoglycan disaccharides by high-performance liquid chromatography using a reverse-phase column with adamantyl groups.

Hisatoshi Hanamatsu, Satoshi Makino, Masatsugu Ohara, Goki Suda, Ikuko Yokota, Shoko Nishihara, Naoya Sakamoto, Jun-Ichi Furukawa

Journal of chromatography. A, 1689 463748-463748, Dec 23, 2022 Peer-reviewed
Toolbox Accelerating Glycomics (TAG): Improving Large-Scale Serum Glycomics and Refinement to Identify SALSA-Modified and Rare Glycans.

Nobuaki Miura, Hisatoshi Hanamatsu, Ikuko Yokota, Keiko Akasaka-Manya, Hiroshi Manya, Tamao Endo, Yasuro Shinohara, Jun-Ichi Furukawa

International journal of molecular sciences, 23(21), Oct 28, 2022 Peer-reviewed
Establishment of the removal method of undifferentiated induced pluripotent stem cells coexisting with chondrocytes using R-17F antibody.

Takuji Miyazaki, Hisatoshi Hanamatsu, Tomohiro Onodera, Jun-Ichi Furukawa, Liang Xu, Kentaro Homan, Rikiya Baba, Toshisuke Kawasaki, Norimasa Iwasaki

Regenerative medicine, 17(11) 793-803, Sep 26, 2022 Peer-reviewed
Glycosphingolipid GM3 prevents albuminuria and podocytopathy induced by anti-nephrin antibody.

Nagako Kawashima, Shokichi Naito, Hisatoshi Hanamatsu, Masaki Nagane, Yasuo Takeuchi, Jun-Ichi Furukawa, Norimasa Iwasaki, Tadashi Yamashita, Ken-Ichi Nakayama

Scientific reports, 12(1) 16058-16058, Sep 26, 2022 Peer-reviewed
Evaluation of the context of downstream N- and free N-glycomic alterations induced by swainsonine in HepG2 cells.

Chie Morikawa, Kanako Sugiura, Keina Kondo, Yurie Yamamoto, Yuma Kojima, Yurika Ozawa, Hiroki Yoshioka, Nobuaki Miura, Jinhua Piao, Kazue Okada …

Biochimica et biophysica acta. General subjects, 1866(9) 130168-130168, May 17, 2022 Peer-reviewed
Comprehensive Cellular Glycan Profiling of Glycoproteins and Glycosphingolipids by Glycoblotting and BEP Methods.

Hisatoshi Hanamatsu, Jun-Ichi Furukawa

Methods in molecular biology (Clifton, N.J.), 2556 1-18, 2022 Peer-reviewedInvited
Comprehensive and Comparative Structural Glycome Analysis in Mouse Epiblast-like Cells

Federico Pecori, Hisatoshi Hanamatsu, Jun ichi Furukawa, Shoko Nishihara

Methods in Molecular Biology, 2490 179-193, 2022 Peer-reviewedInvited
Comprehensive Glycomic Approach Reveals Novel Low-Molecular-Weight Blood Group-Specific Glycans in Serum and Cerebrospinal Fluid.

Jun-Ichi Furukawa, Hisatoshi Hanamatsu, Ikuko Yokota, Megumi Hirayama, Tomohiro Ando, Hiroyuki Kobayashi, Shunsuke Ohnishi, Nobuaki Miura, Kazue Okada, Shota Sakai …

Journal of proteome research, 20(5) 2812-2822, Mar 10, 2021 Peer-reviewed
A defined glycosylation regulatory network modulates total glycome dynamics during pluripotency state transition.

Federico Pecori, Ikuko Yokota, Hisatoshi Hanamatsu, Taichi Miura, Chika Ogura, Hayato Ota, Jun-Ichi Furukawa, Shinya Oki, Kazuo Yamamoto, Osamu Yoshie …

Scientific reports, 11(1) 1276-1276, Jan 14, 2021 Peer-reviewed
Alterations of Glycosphingolipid Glycans and Chondrogenic Markers during Differentiation of Human Induced Pluripotent Stem Cells into Chondrocytes.

Liang Xu, Hisatoshi Hanamatsu, Kentaro Homan, Tomohiro Onodera, Takuji Miyazaki, Jun-Ichi Furukawa, Kazutoshi Hontani, Yuan Tian, Rikiya Baba, Norimasa Iwasaki

Biomolecules, 10(12), Dec 1, 2020 Peer-reviewed
Toolbox Accelerating Glycomics (TAG): Glycan Annotation from MALDI-TOF MS Spectra and Mapping Expression Variation to Biosynthetic Pathways.

Nobuaki Miura, Hisatoshi Hanamatsu, Ikuko Yokota, Kazue Okada, Jun-Ichi Furukawa, Yasuro Shinohara

Biomolecules, 10(10), Sep 28, 2020 Peer-reviewed
Mucin-type O-glycosylation controls pluripotency in mouse embryonic stem cells via Wnt receptor endocytosis.

Federico Pecori, Yoshihiro Akimoto, Hisatoshi Hanamatsu, Jun-Ichi Furukawa, Yasuro Shinohara, Yuzuru Ikehara, Shoko Nishihara

Journal of cell science, 133(20), Sep 24, 2020 Peer-reviewed
Lactone-Driven Ester-to-Amide Derivatization for Sialic Acid Linkage-Specific Alkylamidation.

Jun-Ichi Furukawa, Hisatoshi Hanamatsu, Takashi Nishikaze, Hiroshi Manya, Nobuaki Miura, Hirokazu Yagi, Ikuko Yokota, Keiko Akasaka-Manya, Tamao Endo, Motoi Kanagawa …

Analytical chemistry, 92(21) 14383-14392, Sep 16, 2020 Peer-reviewed
【Human Glycomeがもたらす未来】糖鎖一次構造解析技術の開発要素

花松久寿, 古川潤一

生化学, 92(3) 360-368, Jun, 2020

Misc.

Intercomparison of all glycans expressed in osteoarthritic cartilage

宝満健太郎, 小野寺智洋, 花松久寿, 古川潤一, 松ヶ崎圭純, LIU Yue, KIM WooYoung, 松岡正剛, 岩崎倫政

日本軟骨代謝学会プログラム・抄録集, 35th, 2023
総合グライコミクスアプローチによる変形性関節症標的分子の探索

宝満健太郎, 小野寺智洋, 花松久寿, 古川潤一, 山口純, 細川吉暁, 金佑泳, 松岡正剛, 岩崎倫政

日本整形外科学会雑誌, 96(8), 2022
軟骨統合グライコミクスによる変形性関節症標的因子の探索

宝満健太郎, 小野寺智洋, 花松久寿, 古川潤一, 山口純, 細川吉暁, 松ヶ崎圭純, 金佑泳, 松岡正剛, 岩崎倫政

北海道整形災害外科学会, 141st, 2022
Deficiency of fucosylated glycan in articular cartilage inhibits recovery from damage and promotes cartilage degeneration

宝満健太郎, 小野寺智洋, 花松久寿, 古川潤一, 宮崎拓自, 山口純, 細川吉暁, LIANG Dawei, KIM Woo Young, 江畑拓 …

日本軟骨代謝学会プログラム・抄録集, 34th, 2022
細胞特異的糖鎖解析による定量評価を応用した未分化iPS細胞除去条件の最適化

宮崎拓自, 小野寺智洋, 花松久寿, 古川潤一, 宝満健太郎, 川嵜敏祐, 岩崎倫政

日本整形外科学会雑誌, 95(8), 2021
軟骨のコアフコシル化の喪失は変性からの修復を妨げ変形性関節症を早期化する

宝満健太郎, 小野寺智洋, 濱崎雅成, 徐亮, 宮崎拓自, 山口純, 細川吉暁, 江畑拓, 梁大偉, 金佑泳 …

北海道整形災害外科学会, 139th, 2021
細胞特異的糖鎖解析の手法を用いた残存未分化iPS細胞の定量的評価法の確立

宮崎拓自, 小野寺智洋, 徐亮, 宝満健太郎, 岩崎倫政, 花松久寿, 古川潤一

北海道整形災害外科学会, 139th, 2021
【Human Glycomeがもたらす未来】糖鎖一次構造解析技術の開発要素

花松久寿, 古川潤一

生化学, 92(3) 360-368, Jun, 2020
Glycolipid Expression Analysis Of Chondrocyte-like Cells Derived From Human Induced Pluripotent Stem Cells (hipsc).

Liang Xu, Tomohiro Onodera, Jun-ichi Furukawa, Hisatoshi Hanamatsu, Kentaro Homan, Kazutoshi Hontani, Takuji Miyazaki, Yuan Tian, Norimasa Iwasaki

The 66th Annual Meeting of Orthopaedic Research Society (ORS), 45(PS2-2263), Feb, 2020
Elimination Of Residual Ipscs From Derived Chondrocytes By Using A Cytotoxic Antibody Specifically Bound To Ips May Reduce The Risk Of Tumorigenicity.

Takuji Miyazaki, Tomohiro Onodera, Jun-ichi Furukawa, Hisatoshi Hanamatsu, Liang Xu, Kentaro Homan, Toshisuke Kawasaki, Norimasa Iwasaki

The 66th Annual Meeting of Orthopaedic Research Society (ORS), 45(PS2-1549), Feb, 2020
Comparative Glycomic Analysis by Aminolysis-SALSA method combined with Sialyl Linkage-specific Isotope Labeling.

花松久寿, 西風隆司, 津元裕樹, 小川浩司, 横田育子, 森川賢一, 須田剛生, 荘拓也, 中井正人, 三浦信明 …

日本糖質学会年会要旨集, 39th, 2020
TRI-ANTENNARY TRI-SIALYLATED MONO-FUCOSYLATED GLYCAN OF ALPHA-1 ANTITRYPSIN AS A NON-INVASIVE BIOMARKER FOR NON-ALCOHOLIC STEATOHEPATITIS

Takashi Kobayashi, Koji Ogawa, Jun-Ichi Furukawa, Hisatoshi Hanamatsu, Masato Nakai, Takuya Sho, Goki Suda, Kenichi Morikawa, Megumi Hato, Kenichi Higashino …

HEPATOLOGY, 70 1079A-1079A, Oct, 2019
The Selective Removal Method of Undifferentiated iPS Cells Using Specifi c Antibody for Cartilage Regenerative Medicine.

T. Miyazaki, T. Onodera, L. Xu, H. Hanamatsu, J. Furukawa, K. Homan, M. Hamasaki, R. Hishimura, T. Kawasaki, N. Iwasaki

World Congress of International Chemical Reference Substances (ICRS), 15(P174), Oct, 2019
Identification of M9 high-mannose glycan regulating hypertrophy in articular cartilage

K. Homan, T. Onodera, J. Furukawa, H. Hanamatsu, R. Hishimura, K. Wooyoung, M. Hamasaki, L. Xu, N. Iwasaki

World Congress of International Chemical Reference Substances (ICRS), 15(10.4.8), Oct, 2019
軟骨再生医療への応用を標的とした未分化iPS細胞特異的除去法の検討

宮崎拓自, 小野寺智洋, 徐亮, 花松久寿, 古川潤一, 宝満健太郎, 川嵜敏祐, 岩崎倫政

日本運動器移植・再生医学研究会要旨集, 38, Oct, 2019
M9高マンノース型糖鎖は関節軟骨における肥大化を制御する

宝満健太郎, 小野寺智洋, 花松久寿, 古川潤一, 菱村亮介, 金佑泳, 濱崎雅成, 徐亮, 岩崎倫政

日本整形外科学会雑誌, 93(8) S1682-S1682, Sep 9, 2019
軟骨再生医療への応用を標的とした末分化iPS細胞特異的除去法の検討

宮崎拓自, 小野寺智洋, 徐亮, 花松久寿, 古川潤一, 宝満健太郎, 濱崎雅成, 菱村亮介, 川嵜敏祐, 岩崎倫政

日本整形外科学会雑誌, 93(8) S1664-S1664, Sep 9, 2019
Total Glycome Analysis Through Chondrocyte Hypertrophy.

Kentaro Homan, Tomohiro Onodera, Jun-ichi Furukawa, Hisatoshi Hanamatsu, Ryosuke Hishimura, WooYoung Kim, Masanari Hamasaki, Liang Xu, Norimasa Iwasaki

The 65th Annual Meeting of Orthopaedic Research Society (ORS), 44(PS2-065), Feb, 2019
FPGおよびIPG法による標的タンパク質におけるN-結合型糖鎖解析法の開発

花松久寿, 小林隆史, 小川浩司, 羽藤愛美, 吉永知世, 森川賢一, 須田剛生, 荘拓也, 中井正人, 東野賢一 …

日本糖質学会年会要旨集, 38th, 2019
Fc-融合糖タンパク質医薬品の意図しないO-結合型糖鎖修飾

橋井則貴, 鈴木淳也, 花松久寿, 古川潤一, 石井明子

日本糖質学会年会要旨集, 38th, 2019

Research Projects

Development of Novel Cartilage Regeneration Materials with Functional Glycolipid Molecules

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2025
新規シアル酸様式特異的修飾法を応用したシアリル化糖鎖・糖タンパク質解析法の開発

科学研究費補助金(若手研究), 文部科学省, 2019 - 2021

花松久寿

Industrial Property Rights

特願2018-036367 試料の調製方法および分析方法

花松久寿, 西風隆司, 古川潤一

Profile Information

Research Interests

Research Areas

Awards

Papers

Misc.

Research Projects

Industrial Property Rights

Menu

Coauthors