論文

査読有り 国際誌
2020年11月4日

Comparison of Common and Disease-Specific Post-translational Modifications of Pathological Tau Associated With a Wide Range of Tauopathies

Frontiers in Neuroscience
  • Fuyuki Kametani
  • Mari Yoshida
  • Tomoyasu Matsubara
  • Shigeo Murayama
  • Yuko Saito
  • Ito Kawakami
  • Mitsumoto Onaya
  • Hidetomo Tanaka
  • Akiyoshi Kakita
  • Andrew C. Robinson
  • David M. A. Mann
  • Masato Hasegawa
  • 全て表示

14
開始ページ
581936
終了ページ
581936
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3389/fnins.2020.581936
出版者・発行元
Frontiers Media SA

Tauopathies are the most common type of neurodegenerative proteinopathy, being characterized by cytoplasmic aggregates of hyperphosphorylated tau protein. The formation and morphologies of these tau inclusions, the distribution of the lesions and related metabolic changes in cytoplasm differ among different tauopathies. The aim of this study was to examine whether there are differences in the post-translational modifications (PTMs) in the pathological tau proteins. We analyzed sarkosyl-insoluble pathological tau proteins prepared from brains of patients with Alzheimer's disease, Pick's disease, progressive supranuclear palsy, corticobasal degeneration, globular glial tauopathy, and frontotemporal dementia and parkinsonisms linked to chromosome 17 with tau inclusions using liquid chromatography mass spectrometry. In pathological tau proteins associated with a wide range of tauopathies, 170 PTMs in total were identified including new PTMs. Among them, common PTMs were localized in the N- and C-terminal flanking regions of the microtubule binding repeats and PTMs, which were considered to be disease-specific, were found in microtubule binding repeats forming filament core. These suggested that the differences in PTMs reflected the differences in tau filament core structures in each disease.

リンク情報
DOI
https://doi.org/10.3389/fnins.2020.581936
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33250706
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7672045
URL
https://www.frontiersin.org/articles/10.3389/fnins.2020.581936/full
ID情報
  • DOI : 10.3389/fnins.2020.581936
  • eISSN : 1662-453X
  • PubMed ID : 33250706
  • PubMed Central 記事ID : PMC7672045

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