論文

査読有り 国際誌
2022年1月

Utility of a corticotropin-releasing hormone test to differentiate pituitary-dependent hyperadrenocorticism from cortisol-producing adrenal tumors in dogs.

Journal of veterinary internal medicine
  • Sachiyo Tanaka
  • ,
  • Shuji Suzuki
  • ,
  • Asaka Sato
  • ,
  • Takahiro Teshima
  • ,
  • Akihiro Mori
  • ,
  • Toshinori Sako
  • ,
  • Aki Tanaka
  • ,
  • Yasushi Hara

36
1
開始ページ
29
終了ページ
38
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/jvim.16336

BACKGROUND: Hyperadrenocorticism (HAC) is a common endocrine disorder in dogs; however, there are no reports on the use of the corticotropin-releasing hormone test (CRHT) to differentiate between pituitary-dependent hyperadrenocorticism (PDH) and cortisol-producing adrenal tumors (CPATs), both causative of HAC. OBJECTIVES: To evaluate the usefulness of CRHT as a tool to differentiate between PDH and CPAT in dogs and to determine the reference intervals for CRHT in healthy, PDH, and CPAT dogs. ANIMALS: Dogs diagnosed with PDH (n = 21), CPAT (n = 6), and healthy beagle dogs (n = 33). METHODS: This prospective study included dogs with a definitive diagnosis of PDH and CPAT and healthy beagle dogs, in which CRHT was performed, were prospectively evaluated. We investigated the correlations of CRHT (endogenous adrenocorticotropic hormone [ACTH] concentration, endogenous ACTH concentration [EAC], and poststimulation ACTH concentration [PAC]) with pituitary-to-brain ratio (PBR) (in PDH) and with indices of adrenal ultrasonography (smaller and larger adrenal gland dorsoventral thickness in PDH and CPAT). RESULTS: For EAC, the area under the curve (AUC) was 0.95, with a cutoff value of 26.3 pg/mL (sensitivity: 90.62%, specificity: 87.50%). The AUC for PAC was 0.96 with a cutoff value of 54.5 pg/mL (sensitivity: 100.00%, specificity: 66.67%). The 95% reference interval for CRHT in healthy (control) dogs ranged 5.00 to 79.8 pg/mL (1.10-17.57 pmol/L) for EAC, and 1.92 to 153.42 pg/mL (0.42-33.78 pmol/L) for PAC. There was no significant correlation between PBR and CRHT, nor adrenal size and CRHT. CONCLUSIONS AND CLINICAL IMPORTANCE: CRHT appears to be a rapid and reliable test for differentiating PDH from CPAT in dogs.

リンク情報
DOI
https://doi.org/10.1111/jvim.16336
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/34859496
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8783340
ID情報
  • DOI : 10.1111/jvim.16336
  • PubMed ID : 34859496
  • PubMed Central 記事ID : PMC8783340

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