中江大 (Dai Nakae) - マイポータル

基本情報

所属: 帝京平成大学健康医療スポーツ学部医療スポーツ学科動物医療コース教授

学位: 医学博士(1989年5月奈良県立医科大学)

J-GLOBAL ID: 201401037262479497
researchmap会員ID: B000242583

外部リンク: http://kaken.nii.ac.jp/d/r/90207712.ja.html

研究キーワード

研究分野

経歴

2022年4月 - 現在

帝京平成大学, 健康医療スポーツ学部医療スポーツ学科動物医療コース, 教授
2015年4月 - 2022年3月

東京農業大学, 応用生物科学部食品安全健康学科食品安全評価学研究室, 教授

論文

221

Drug review process advancement and required manufacturer and contract research oraganization responses.

Takayuki Anzai, Glenn J Myatt, Frances Hall, Brenda Finney, Kenshi Nakagawa, Hijiri Iwata, Reo Anzai, Anne Dickinson, Matthew Freer, Dai Nakae …

Journal of toxicologic pathology 37(2) 45-53 2024年4月
Urinary liver‐type fatty acid binding protein is a biomarker reflecting renal damage and the ameliorative effect of drugs at an early stage of histone‐induced <scp>acute kidney injury</scp>

Keiichi Ohata, Takeshi Sugaya, Hanh Nhung Nguyen, Karin Arai, Yuri Hatanaka, Kinuko Uno, Marika Tohma, Teppei Uechi, Keita Sekiguchi, Tsuyoshi Oikawa …

Nephrology 29(3) 117-125 2023年11月11日
Time-Course of Transcriptomic Change in the Lungs of F344 Rats Repeatedly Exposed to a Multiwalled Carbon Nanotube in a 2-Year Test.

Motoki Hojo, Ai Maeno, Yoshimitsu Sakamoto, Yukio Yamamoto, Yuhji Taquahashi, Akihiko Hirose, Jin Suzuki, Akiko Inomata, Dai Nakae

Nanomaterials (Basel, Switzerland) 13(14) 2023年7月19日
Urinary liver-type fatty acid binding protein is increased in the early stages of the disease with a risk of acute kidney injury induced by histone.

Keiichi Ohata, Takeshi Sugaya, Hanh Nhung Nguyen, Yuri Hatanaka, Kinuko Uno, Marika Tohma, Tsuyoshi Oikawa, Hiroshi Nagabukuro, Kanako Kuniyeda, Atsuko Kamijo-Ikemori …

Nephrology (Carlton, Vic.) 28(6) 345-355 2023年6月
Nonalcoholic steatohepatitis-associated hepatocarcinogenesis in mice fed a modified choline-deficient, methionine-lowered, L-amino acid-defined diet and the role of signal changes.

Noriko Suzuki-Kemuriyama, Akari Abe, Sae Nakane, Megumi Yuki, Katsuhiro Miyajima, Dai Nakae

PloS one 18(8) e0287657 2023年
Continuous infiltration of small peritoneal macrophages in the mouse peritoneum through CCR2-dependent and -independent routes during fibrosis and mesothelioma development induced by a multiwalled carbon nanotube, MWNT-7.

Motomu Shimizu, Motoki Hojo, Kiyomi Ikushima, Yukio Yamamoto, Ai Maeno, Yoshimitsu Sakamoto, Naozumi Ishimaru, Yuhji Taquahashi, Jun Kanno, Akihiko Hirose …

The Journal of toxicological sciences 48(12) 617-639 2023年
Effects of Siraitia grosvenorii extract on nonalcoholic steatohepatitis-like lesions in Sprague Dawley rats fed a choline-deficient, methionine-lowered, l-amino acid-defined diet

Kinuko Uno, Katsuhiro Miyajima, Shuji Ogawa, Noriko Suzuki-Kemuriyama, Dai Nakae

Journal of Toxicologic Pathology 36(1) 1-10 2023年
Effects of Siraitia grosvenorii extract on nonalcoholic steatohepatitis-like lesions in Sprague Dawley rats fed a choline-deficient, methionine-lowered, l-amino acid-defined diet

Kinuko Uno, Katsuhiro Miyajima, Shuji Ogawa, Noriko Suzuki-Kemuriyama, Dai Nakae

JOURNAL OF TOXICOLOGIC PATHOLOGY 36(1) 1-10 2023年
Effects of Siraitia grosvenorii extract on nonalcoholic steatohepatitis-like lesions in Sprague Dawley rats fed a choline-deficient, methionine-lowered, l-amino acid-defined diet.

Kinuko Uno, Katsuhiro Miyajima, Shuji Ogawa, Noriko Suzuki-Kemuriyama, Dai Nakae

Journal of toxicologic pathology 36(1) 1-10 2023年1月
Correction to: A trans fatty acid substitute enhanced development of liver proliferative lesions induced in mice by feeding a cholinedeficient, methionine-lowered, L-amino acid-defined, high-fat diet. (Lipids in Health and Disease, (2020), 19, 1, (251), 10.1186/s12944-020-01423-3)

Noriko Suzuki-Kemuriyama, Akari Abe, Kinuko Uno, Shuji Ogawa, Atsushi Watanabe, Ryuhei Sano, Megumi Yuki, Katsuhiro Miyajima, Dai Nakae

Lipids in Health and Disease 21(1) 2022年12月
Two-year intermittent exposure of a multiwalled carbon nanotube by intratracheal instillation induces lung tumors and pleural mesotheliomas in F344 rats

Motoki Hojo, Ai Maeno, Yoshimitsu Sakamoto, Aya Ohnuki, Yukie Tada, Yukio Yamamoto, Kiyomi Ikushima, Ryota Inaba, Jin Suzuki, Yuhji Taquahashi …

Particle and Fibre Toxicology 19(1) 38-38 2022年12月
CD44 expression in the bile duct epithelium is related to hepatic fibrosis in nonalcoholic steatohepatitis rats induced by a choline-deficient, methionine-lowered, L-amino acid diet.

Kinuko Uno, Katsuhiro Miyajima, Marika Toma, Noriko Suzuki-Kemuriyama, Dai Nakae

Journal of toxicologic pathology 35(2) 149-157 2022年4月
Iron oxide nanoparticles exert inhibitory effects on N-Bis(2-hydroxypropyl)nitrosamine (DHPN)-induced lung tumorigenesis in rats.

Yukie Tada, Motoki Hojo, Katsuhiro Yuzawa, Akemichi Nagasawa, Jin Suzuki, Akiko Inomata, Takako Moriyasu, Dai Nakae

Regulatory toxicology and pharmacology : RTP 128 105072-105072 2022年2月
Correction to: A trans fatty acid substitute enhanced development of liver proliferative lesions induced in mice by feeding a cholinedeficient, methionine-lowered, L-amino acid-defined, high-fat diet.

Noriko Suzuki-Kemuriyama, Akari Abe, Kinuko Uno, Shuji Ogawa, Atsushi Watanabe, Ryuhei Sano, Megumi Yuki, Katsuhiro Miyajima, Dai Nakae

Lipids in health and disease 21(1) 2-2 2022年1月7日
CD44 expression in the bile duct epithelium is related to hepatic fibrosis in nonalcoholic steatohepatitis rats induced by a choline-deficient, methionine-lowered, L-amino acid diet

Kinuko Uno, Katsuhiro Miyajima, Marika Toma, Noriko Suzuki Kemuriyama, Dai Nakae

Journal of Toxicologic Pathology 35(2) 149-157 2022年
CD44 expression in the bile duct epithelium is related to hepatic fibrosis in nonalcoholic steatohepatitis rats induced by a choline-deficient, methionine-lowered, L-amino acid diet

Kinuko Uno, Katsuhiro Miyajima, Marika Toma, Noriko Suzuki-Kemuriyama, Dai Nakae

JOURNAL OF TOXICOLOGIC PATHOLOGY 35(2) 149-157 2022年
Nonobese mice with nonalcoholic steatohepatitis fed on a choline-deficient, l-amino acid-defined, high-fat diet exhibit alterations in signaling pathways

Noriko Suzuki-Kemuriyama, Akari Abe, Sae Nakane, Kinuko Uno, Shuji Ogawa, Atsushi Watanabe, Ryuhei Sano, Megumi Yuki, Katsuhiro Miyajima, Dai Nakae

FEBS Open Bio 11(11) 2950-2965 2021年11月
Nonobese mice with nonalcoholic steatohepatitis fed on a choline-deficient, l-amino acid-defined, high-fat diet exhibit alterations in signaling pathways

Noriko Suzuki-Kemuriyama, Akari Abe, Sae Nakane, Kinuko Uno, Shuji Ogawa, Atsushi Watanabe, Ryuhei Sano, Megumi Yuki, Katsuhiro Miyajima, Dai Nakae

FEBS OPEN BIO 11(11) 2950-2965 2021年11月
Nonobese mice with nonalcoholic steatohepatitis fed on a choline-deficient, l-amino acid-defined, high-fat diet exhibit alterations in signaling pathways.

Noriko Suzuki-Kemuriyama, Akari Abe, Sae Nakane, Kinuko Uno, Shuji Ogawa, Atsushi Watanabe, Ryuhei Sano, Megumi Yuki, Katsuhiro Miyajima, Dai Nakae

FEBS open bio 11(11) 2950-2965 2021年11月
A case of spontaneous zymbal’s gland carcinoma with lung metastasis in an aged fischer 344 rat

Ai Maeno, Yoshimitsu Sakamoto, Motoki Hojo, Yukie Tada, Jin Suzuki, Akiko Inomata, Takako Moriyasu, Akihiko Hirose, Noriko Kemuriyama, Katsuhiro Miyajima …

Journal of Toxicologic Pathology 34(4) 353-358 2021年10月1日

もっとみる

MISC

Hepatocarcinogenesis associated with NASH in mice fed a CDAA-HF-T(-) and the involvement of the signal factors

Noriko Kemuriyama, Akari Abe, Megumi Yuki, Kinuko Uno, Sae Nakane, Katsuhiro Miyajima, Dai Nakae

CANCER SCIENCE 113 558-558 2022年2月
A trans fatty acid substitute enhanced development of liver proliferative lesions induced in mice by feeding a cholinedeficient, methionine-lowered, L-amino acid-defined, high-fat diet (vol 19, 251, 2020)

Noriko Suzuki-Kemuriyama, Akari Abe, Kinuko Uno, Shuji Ogawa, Atsushi Watanabe, Ryuhei Sano, Megumi Yuki, Katsuhiro Miyajima, Dai Nakae

LIPIDS IN HEALTH AND DISEASE 21(1) 2022年1月
2型糖尿病モデルdb/db及びKK-Ayマウスにおける高脂肪食給餌による肝臓への影響

万代康平, 美谷島克宏, 北村沙也夏, 山口彩音, 宇野絹子, 黒木楓子, 西田芽衣, 白坂航大, 筒井誉大, 武呂大和 …

第48回日本毒性学会講演要旨 46(Suppl.) S109-S110 2021年7月
2型糖尿病モデルdb/dbおよびKK-Ayマウスの腎臓における高脂肪食摂餌の影響

山口彩音, 美谷島克宏, 宇野絹子, 杉本実紀, 黒木楓子, 西田芽衣, 小郷智記, 煙山紀子, 篠原雅巳, 中江大 …

The Journal of Toxicological Sciences 45(Suppl.) S103-S103 2020年6月
Development of an animal hepatocarcinogenesis model through non-obese (Asian-type) nonalcoholic steatohepatitis (NASH)

Noriko Kemuriyama, Satomi Uchino, Syunta Sato, Haruka Funamizu, Linfeng Gao, Kanjiro Ryuu, Kinuko Uno, Soon Hui Teoh, Syuuji Ogawa, Atsushi Watanabe …

CANCER SCIENCE 109 1041-1041 2018年12月
A mouse model of nonalcoholic steatohepatitis using a choline-deficient, methionine-lowered, L-amino acid-defined diet

Noriko Kemuriyama, Kaori Ikehata, Takuya Yamashita, Kinuko Uno, Soon Hui Teoh, Shuji Ogawa, Atsushi Watanabe, Katsuhiro Miyajima, Dai Nakae

CANCER SCIENCE 109 780-780 2018年1月
Responses to the standard for exchange of nonclinical data (SEND) in non-US countries

Takayuki Anzai, Masamichi Kaminishi, Keizo Sato, Laura Kaufman, Hijiri Iwata, Dai Nakae

Journal of Toxicologic Pathology 28(2) 57-64 2015年4月1日査読有り責任著者
Nitric oxide and cancer development

Robert A. Floyd, Yashige Kotake, Rheal A. Towner, We-Xing Guo, Dai Nakae, Yoichi Konishi

Journal of Toxicologic Pathology 20(2) 77-92 2007年7月2日査読有り
Antioxidant and signal-normalizing properties of phenyl N-tert-butyl nitrone and its derivatives in chemoprevention of hepatocellular carcinoma

D. Nakae, R. A. Floyd

CHEMICO-BIOLOGICAL INTERACTIONS 161(3) 196-196 2006年7月筆頭著者
コリン欠乏アミノ酸(CDAA)食によるマウス肝発がんに対するOgg1遺伝子欠損の修飾効果

傳田阿由美, 中江大, 笹平智則, 木下アンナ, 鰐渕英機, 福島昭治, 國安弘基

日本癌学会学術総会記事 65th 2006年
S-nitrosylation in the development of choline deficiency-induced hepatocellular carcinoma

WX Guo, RH Broyles, R Towner, K Hensley, D Nakae, Y Kotake, RA Floyd

FREE RADICAL BIOLOGY AND MEDICINE 39 S165-S165 2005年
Role of nitric oxide in hepatocellular carcinoma development

RA Floyd, R Towner, WX Guo, K Hensley, RH Broyles, D Nakae, Y Kotake

FREE RADICAL BIOLOGY AND MEDICINE 39 S84-S84 2005年査読有り
O-11 Dietary indole-3-carbinol promotes endometrial adenocarcinoma development in rats by increase of cytochrome P450 activities and modulation of estrogen metabolism in the liver(CARCINOGENICITY)(GENERAL SESSION BY ORAL PRESENTATION)(Proceedings of the 31st Annual Meeting)

YOSHIDA Midori, NAKAE Dai, MAEKAWA Akihiko

Journal of toxicological sciences 29(4) 398-398 2004年10月29日
Existence of a threshold for induction of aberrant crypt foci in the rat colon with low doses of 2-amino-1-methyl-6-phenolimidazo[4,5-b]pyridine

S. Fukushima, H. Wanibuchi, K. Morimura, S. Iwai, D. Nakae, H. Kishida, H. Tsuda, N. Uehara, K. Imaida, T. Shirai …

Toxicological Sciences 80(1) 109-114 2004年7月査読有り
Dietary indole-3-carbinol promotes endometrial adenocarcinoma development in rats by increase of cytochrome P450 activities and modulation of estrogen metabolism in the liver

M Yoshida, D Nakae, A Maekawa

TOXICOLOGY AND APPLIED PHARMACOLOGY 197(3) 243-244 2004年6月査読有り
Inhibitory effect of hydroxymatairesinol on the development of endometrial adenocarcinomas in rats

SI Katsuda, M Yoshida, N Saarinen, A Smeds, D Nakae, R Santti, A Maekawa

TOXICOLOGY AND APPLIED PHARMACOLOGY 197(3) 200-201 2004年6月
Carcinogenic risks in the high-risk groups (SYMPOSIUM3: RECENT TOPICS ON THE RISK ASSESSMENT OF CHEMICAL CARCINOGENS) (Proceedings of the 30th Annual Meeting)

Nakae Dai, Takahashi Masakazu, Yoshida Midori, Uematsu Fumiyuki, Maekawa Akihiko

Journal of toxicological sciences 28(4) 242-242 2003年10月31日
Effect of neonatal exposure of high dose p-tert octylphenol on the ovary in rats (ENDOCRINE SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)

Yoshida Midori, Katashima Sayumi, Maekawa Akihiko, Nakae Dai

Journal of toxicological sciences 28(4) 321-321 2003年10月31日
Narama, I., Imaida, K., Iwata, H., Nakae, D., Nishikawa, A., Harada, T.: A review of nomenclature and diagnostic criteria for proliferative lesions in the liver of rats by a working group of the Japanese Society of Toxicologic Pathology.

Isao Narama, Katsumi Imaida, Hijiri Iwata, Dai Nakae, Akiyoshi Nishikawa, Takanori Harada

J. Toxicol. Pathol. 16(1) 1-17 2003年
A flow cytometry study on nitric oxide and ROS formation in primary hepatocytes isolated from rats fed with an amino acid diet.

Y Kotake, H Kishida, D Nakae, RA Floyd

FREE RADICAL BIOLOGY AND MEDICINE 33 S260-S260 2002年

もっとみる

書籍等出版物

図で見る公衆衛生学

河村, 葉子, 中江, 大, 長野, 嘉介, 吉川, 邦衛, 米澤, 加代

学術研究出版/ブックウエイ 2017年3月 (ISBN: 9784865842227)
図で見る公衆衛生学

河村, 葉子, 菅谷, 紘一, 中室, 克彦, 長野, 嘉介, 中江, 大, 吉川, 邦衛, 米澤, 加代

学術研究出版/ブックウエイ 2015年3月 (ISBN: 9784865840254)

共同研究・競争的資金等の研究課題

がん研究の資材有効保存と利用に関する研究

日本学術振興会科学研究費助成事業特定領域研究 2005年 - 2009年

清木元治, 松居靖久, 丹羽太貫, 佐竹正延, 立松正衛, 福島昭治, 中江大
食餌中の栄養素組成の変動操作のみで誘導される内因性発がんの機構に関する研究

日本学術振興会科学研究費助成事業基盤研究(C) 2004年 - 2005年

中江大, 高橋正一, 増村健一
環境因子の発がんリスク評価

日本学術振興会科学研究費助成事業重点領域研究 1996年 - 1999年

福島昭治, 津田洋幸, 立松正衛, 広瀬雅雄, 今井田克己, 中江大, 高橋道人
膵癌の発生・増殖と進展及びその制御に関する基礎的研究

日本学術振興会科学研究費助成事業基盤研究(A) 1996年 - 1999年

小西陽一, 堤雅弘, 傳田阿由美, 中江大, 辻内俊文
ラット肝における酸化性DNA障害依存性発癌機構と肝細胞壊死

日本学術振興会科学研究費助成事業奨励研究(A) 1992年 - 1992年

中江大

中江大

基本情報

研究キーワード

研究分野

経歴

論文

MISC

書籍等出版物

共同研究・競争的資金等の研究課題

メニュー

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