Shigeki Aoki - My portal

Profile Information

Affiliation: Associate Professor, Chiba University

Degree: 博士（薬学）(東京大学)

Researcher number: 30728366
J-GLOBAL ID: 201801021134687768
researchmap Member ID: B000336453

External link: http://www.p.chiba-u.jp/lab/yakuzai/

Research Interests

Research Areas

Life sciences / Clinical pharmacy / 薬物毒性学、臨床薬理学

Research History

Oct, 2024 - Present

Associate Professor, Graduate School of Pharmaceutical Sciences, Chiba University
Apr, 2019 - Sep, 2024

Lecturer, Graduate School of Pharmaceutical Sciences, Chiba University
Nov, 2018 - Mar, 2019

Graduate School of Pharmaceutical Sciences, Chiba University
Nov, 2013 - Oct, 2018

Graduate School of Pharmaceutical Sciences, Chiba University
Apr, 2013 - Oct, 2013

Pharmaceuticals and Medical Devices Agency
Apr, 2011 - Mar, 2013

特別研究員（ＤＣ２）, 日本学術振興会

Education

Apr, 2010 - Mar, 2013

Department of Pharmaceutical Technology, Graduate School of Pharmaceutical Sciences, The University of Tokyo
Apr, 2008 - Mar, 2010

Department of Pharmaceutical Technology, Graduate School of Pharmaceutical Sciences, The University of Tokyo
Apr, 2006 - Mar, 2008

Department of Pharmacy, Faculty of Pharmaceutical Sciences, The University of Tokyo
Apr, 2004 - Mar, 2006

College of Arts and Sciences, The University of Tokyo

Committee Memberships

Awards

Apr, 2023

JAICI賞, 薬物副作用の個人差の背景に潜むメカニズムの解明, 化学情報協会

青木重樹
Mar, 2023

Award for Young Scientists, Elucidation of mechanism underlying individual differences in adverse drug reactions, The Pharmaceutical Society of Japan

Shigeki Aoki
Nov, 2021

ベストポスター賞, Elimination of Immunosuppressive Factors Clearly Exhibits Idiosyncratic Toxicity by Abacavir in HLA-B*57:01-Transgenic Mice, 日本薬物動態学会第36回年会
Jul, 2021

技術賞, ヒトHLAトランスジェニックマウスを用いた特異体質薬物毒性理解への取り組み, 日本毒性学会
Sep, 2020

奨励賞, 薬物による副作用発症の個人差を決定するHLAの重要性, 日本薬学会関東支部
Sep, 2020

奨励賞, HLA遺伝子導入マウスを用いた特異体質薬物毒性研究, 日本免疫毒性学会
Jul, 2020

優秀研究発表賞, HLA多型特異的な薬物性の免疫毒性発症に対する免疫寛容系の関与, 第47回日本毒性学会学術年会
Jun, 2020

Highlighted paper selected by Editor-in-Chief, Detection of abacavir-induced structural alterations in human leukocyte antigen-B*57:01 using phage display, Biol.Pharm.Bull.

Shirayanagi T, Aoki S*, Fujimori S, Watanabe K, Aida T, Hirasawa M, Kumagai K, Hoshino T, Ito K. (* Corresponding author)
Nov, 2017

グローバルプロミネント研究基幹シンポジウム優秀発表賞, がん代謝アダプテーションの鍵を握るオートファジー, 千葉大学

Major Papers

16

Elucidating the Mechanisms Underlying Interindividual Differences in the Onset of Adverse Drug Reactions

Shigeki Aoki

Biological and Pharmaceutical Bulletin, 47(6) 1079-1086, Jun 1, 2024 Peer-reviewedInvitedLead authorLast authorCorresponding author
119

Potential role of lipophagy impairment for anticancer effects of glycolysis-suppressed pancreatic ductal adenocarcinoma cells

Zhiheng Zhang, Haruna Aoki, Keitaro Umezawa, Joshua Kranrod, Natsumi Miyazaki, Taichi Oshima, Takuya Hirao, Yuri Miura, John Seubert, Kousei Ito …

Cell Death Discovery, 10(1), Apr 5, 2024 Peer-reviewedLast authorCorresponding author
35

HLA-B*57:01-dependent intracellular stress in keratinocytes triggers dermal hypersensitivity reactions to abacavir

Akira Kazaoka, Sota Fujimori, Yushiro Yamada, Tomohiro Shirayanagi, Yuying Gao, Saki Kuwahara, Naoki Sakamoto, Takeshi Susukida, Shigeki Aoki, Kousei Ito

PNAS Nexus, 3(4), Apr 2, 2024 Peer-reviewedCorresponding author
30

Pathological changes in various organs in HLA-B*57:01 transgenic mice with abacavir-induced skin eruption

Akira Kazaoka, Kazuyoshi Kumagai, Junya Matsushita, Tetsuo Aida, Saki Kuwahara, Shigeki Aoki, Kousei Ito

Toxicological Research, Jan 6, 2024 Peer-reviewedCorresponding author
201

PINK1-dependent and Parkin-independent mitophagy is involved in reprogramming of glycometabolism in pancreatic cancer cells

Natsumi Miyazaki, Reika Shiratori, Taichi Oshima, Zhiheng Zhang, Robert Valencia, Joshua Kranrod, Liye Fang, John M. Seubert, Kousei Ito, Shigeki Aoki

Biochemical and Biophysical Research Communications, 625 167-173, Oct, 2022 Peer-reviewedLast authorCorresponding author
34

TARC/CCL17 Expression Is Associated with CD8+ T Cell Recruitment in Abacavir-Induced Skin Hypersensitivity in HLA-Transgenic Mice

Yuying Gao, Saki Kuwahara, Akira Kazaoka, Kousei Ito, Shigeki Aoki

Biological and Pharmaceutical Bulletin, 45(9) 1347-1353, Sep 1, 2022 Peer-reviewedLast authorCorresponding author
142

Weak complex formation of adverse drug reaction-associated HLA-B57, B58, and B15 molecules

Tomohiro Shirayanagi, Akira Kazaoka, Kenji Watanabe, Liang Qu, Naoki Sakamoto, Tyuji Hoshino, Kousei Ito, Shigeki Aoki

Toxicology in vitro : an international journal published in association with BIBRA, 82 105383-105383, May 11, 2022 Peer-reviewedLast authorCorresponding author
57

Regulation of the immune tolerance system determines the susceptibility to HLA-mediated abacavir-induced skin toxicity

Takeshi Susukida, Saki Kuwahara, Binbin Song, Akira Kazaoka, Shigeki Aoki, Kousei Ito

Communications Biology, 4(1) 1137-1137, Dec, 2021 Peer-reviewedCorresponding author
114

Aldo-keto reductase inhibitors increase the anticancer effects of tyrosine kinase inhibitors in chronic myelogenous leukemia

Megumi Kikuya, Kenta Furuichi, Takuya Hirao, Satoshi Endo, Naoki Toyooka, Kousei Ito, Shigeki Aoki

Journal of Pharmacological Sciences, 147(1) 1-8, Sep, 2021 Peer-reviewedLast authorCorresponding author
103

Importance of HLA in Determining Individual Differences in the Onset of Adverse Drug Reactions

Shigeki Aoki

YAKUGAKU ZASSHI, 141(8) 1001-1007, Aug 1, 2021 Peer-reviewedInvitedLead authorLast authorCorresponding author
121

HLA transgenic mice: application in reproducing idiosyncratic drug toxicity

Takeshi Susukida, Shigeki Aoki, Tomohiro Shirayanagi, Yushiro Yamada, Saki Kuwahara, Kousei Ito

Drug Metabolism Reviews, 52(4) 1-28, Aug 27, 2020 Peer-reviewedInvited
195

Autophagy-dependent mitochondrial function regulates osteoclast differentiation and maturation

Shigeki Aoki, Kengo Shimizu, Kousei Ito

Biochemical and biophysical research communications, 527(4) 874-880, Jul 5, 2020 Peer-reviewedLead authorCorresponding author
55

Detection of Abacavir-Induced Structural Alterations in Human Leukocyte Antigen-B*57:01 Using Phage Display

Tomohiro Shirayanagi, Shigeki Aoki, Sota Fujimori, Kenji Watanabe, Tetsuo Aida, Makoto Hirasawa, Kazuyoshi Kumagai, Tyuji Hoshino, Kousei Ito

Biological & pharmaceutical bulletin, 43(6) 1007-1015, 2020 Peer-reviewedCorresponding author
44

Glycolytic suppression dramatically changes the intracellular metabolic profile of multiple cancer cell lines in a mitochondrial metabolism-dependent manner

Reika Shiratori, Kenta Furuichi, Masashi Yamaguchi, Natsumi Miyazaki, Haruna Aoki, Hiroji Chibana, Kousei Ito, Shigeki Aoki

Scientific reports, 9(1) 18699-18699, Dec 10, 2019 Peer-reviewedLast authorCorresponding author
46

Complex formation between platelet-derived growth factor receptor β and transforming growth factor β receptor regulates the differentiation of mesenchymal stem cells into cancer-associated fibroblasts

Kaori Aoto, Kousei Ito, Shigeki Aoki

Oncotarget, 9(75) 34090-34102, Sep 25, 2018 Peer-reviewedLast authorCorresponding author
47

Coupling of bone resorption and formation by RANKL reverse signalling

Ikebuchi Y, Aoki S, Honma M, Hayashi M, Sugamori Y, Khan M, Kariya Y, Kato G, Tabata Y, Penninger JM …

Nature, 561(7722) 195-200, Sep, 2018 Peer-reviewedLead author
51

An Animal Model of Abacavir-Induced HLA-Mediated Liver Injury

Binbin Song, Shigeki Aoki, Cong Liu, Takeshi Susukida, Kousei Ito

Toxicological sciences : an official journal of the Society of Toxicology, 162(2) 713-723, Apr 1, 2018 Peer-reviewed
57

Evaluation of immune-mediated idiosyncratic drug toxicity using chimeric HLA transgenic mice

Takeshi Susukida, Shigeki Aoki, Kotaro Kogo, Sota Fujimori, Binbin Song, Cong Liu, Shuichi Sekine, Kousei Ito

Archives of toxicology, 92(3) 1177-1188, Mar, 2018 Peer-reviewed
83

Altered intracellular signaling by imatinib increases the anti-cancer effects of tyrosine kinase inhibitors in chronic myelogenous leukemia cells

Takuya Hirao, Masashi Yamaguchi, Megumi Kikuya, Hiroji Chibana, Kousei Ito, Shigeki Aoki

Cancer science, 109(1) 121-131, Jan, 2018 Peer-reviewedLast authorCorresponding author