2018年3月14日
Synthesis and stereochemistry of JBIR-81, a peptide enamide derived from aspergilli
Tetrahedron Letters
- ,
- ,
- ,
- ,
- 巻
- 59
- 号
- 11
- 開始ページ
- 1010
- 終了ページ
- 1013
- 記述言語
- 英語
- 掲載種別
- 研究論文（学術雑誌）
- DOI
- 10.1016/j.tetlet.2018.01.080
- 出版者・発行元
- Elsevier Ltd
The absolute stereochemistry of an aspergilli-derived peptide enamide, JBIR-81, was determined to be 12S, 15S by the first synthesis of (12S,15S)-JBIR-81 and its epimer. The overall yield was 56% over six steps from N-methyl-L-leucine. The (Z)-enamide structure was effectively constructed with use of a copper (I) catalyzed coupling reaction between a vinyl halide and a carboxamide.
- ID情報
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- DOI : 10.1016/j.tetlet.2018.01.080
- ISSN : 1873-3581
- ISSN : 0040-4039
- SCOPUS ID : 85042189174