Yuko Arioka - My portal

Profile Information

Affiliation: Hospital, Nagoya University
: 精神医学分野

Degree: 博士（人間健康科学）(京都大学)

J-GLOBAL ID: 201801015238275526
researchmap Member ID: B000333103

Research Areas

Research History

Jun, 2020 - Present

特任講師, 名古屋大学医学部附属病院/医学系研究科
Apr, 2020 - Present

Fujita Health University
Jul, 2014 - May, 2020

Graduate School of Medicine, Nagoya University
Apr, 2013 - Jun, 2014

Graduate School of Medicine, Gifu University

Awards

Papers

Phenotypes for general behavior, activity, and body temperature in 3q29 deletion model mice

Daisuke Mori, Ryosuke Ikeda, Masahito Sawahata, Sho Yamaguchi, Akiko Kodama, Takashi Hirao, Yuko Arioka, Hiroki Okumura, Chihiro Inami, Toshiaki Suzuki …

Translational Psychiatry, 14(1), Mar 7, 2024
Indoleamine 2,3-dioxygenase 2 deficiency associates with autism-like behavior via dopaminergic neuronal dysfunction.

Masaki Ishikawa, Yasuko Yamamoto, Bolati Wulaer, Kazuo Kunisawa, Hidetsugu Fujigaki, Tatsuya Ando, Hiroki Kimura, Itaru Kushima, Yuko Arioka, Youta Torii …

The FEBS journal, 291(5) 945-964, Mar, 2024
Analysis of human neuronal cells carrying ASTN2 deletion: A cross-disorder risk variant of schizophrenia, autism spectrum disorder, and bipolar disorder

Yuko Arioka, Yu Hayashi, Hiroki Okumura, Itaru Kushima, Daisuke Mori, Tzuyao Lo, Gantsooj Otgonbayar, Hidekazu Kato, Yoshihiro Nawa, Hiroki Kimura …

Feb 21, 2023
Investigation of OLIG2 as a candidate gene for schizophrenia and autism spectrum disorder.

Sho Furuta, Branko Aleksic, Yoshihiro Nawa, Hiroki Kimura, Itaru Kushima, Kanako Ishizuka, Hidekazu Kato, Miho Toyama, Yuko Arioka, Daisuke Mori …

Nagoya journal of medical science, 84(2) 260-268, May, 2022
Cross-disorder analysis of genic and regulatory copy number variations in bipolar disorder, schizophrenia, and autism spectrum disorder

Itaru Kushima, Masahiro Nakatochi, Branko Aleksic, Takashi Okada, Hiroki Kimura, Hidekazu Kato, Mako Morikawa, Toshiya Inada, Kanako Ishizuka, Youta Torii …

Biological Psychiatry, 92(5) 362-374, Apr, 2022
Sequencing of selected chromatin remodelling genes reveals increased burden of rare missense variants in ASD patients from the Japanese population

Tzuyao Lo, Itaru Kushima, Branko Aleksic, Hidekazu Kato, Yoshihiro Nawa, Yu Hayashi, Gantsooj Otgonbayar, Hiroki Kimura, Yuko Arioka, Daisuke Mori …

International Review of Psychiatry, 34(2) 154-167, Feb 17, 2022
[A New Outlook on Mental Disorders: Pathological Dynamics of Glial Cells].

Yuko Arioka, Daisuke Kato, Hiroaki Wake, Norio Ozaki

Brain and nerve = Shinkei kenkyu no shinpo, 73(7) 787-794, Jul, 2021
Chromosome 22q11.2 deletion causes PERK-dependent vulnerability in dopaminergic neurons.

Yuko Arioka, Emiko Shishido, Itaru Kushima, Toshiaki Suzuki, Ryo Saito, Atsu Aiba, Daisuke Mori, Norio Ozaki

EBioMedicine, 63 103138-103138, Jan, 2021 Peer-reviewed
Rare genetic variants in the gene encoding histone lysine demethylase 4C (KDM4C) and their contributions to susceptibility to schizophrenia and autism spectrum disorder.

Hidekazu Kato, Itaru Kushima, Daisuke Mori, Akira Yoshimi, Branko Aleksic, Yoshihiro Nawa, Miho Toyama, Sho Furuta, Yanjie Yu, Kanako Ishizuka …

Translational psychiatry, 10(1) 421-421, Dec 5, 2020 Peer-reviewed
Involvement of nicotinic acetylcholine receptors in behavioral abnormalities and psychological dependence in schizophrenia-like model mice.

Yukihiro Noda, Mizuki Uchida, Akihiro Mouri, Shokuro Yamada, Sakika Goto, Shinji Kitagaki, Takayoshi Mamiya, Itaru Kushima, Yuko Arioka, Norio Ozaki …

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 41 92-105, Dec, 2020 Peer-reviewed
Rare single-nucleotide DAB1 variants and their contribution to Schizophrenia and autism spectrum disorder susceptibility.

Yoshihiro Nawa, Hiroki Kimura, Daisuke Mori, Hidekazu Kato, Miho Toyama, Sho Furuta, Yanjie Yu, Kanako Ishizuka, Itaru Kushima, Branko Aleksic …

Human genome variation, 7(1) 37-37, Nov 10, 2020 Peer-reviewed
Effect of intranasal oxytocin on the core social symptoms of autism spectrum disorder: a randomized clinical trial.

Hidenori Yamasue, Takashi Okada, Toshio Munesue, Miho Kuroda, Toru Fujioka, Yota Uno, Kaori Matsumoto, Hitoshi Kuwabara, Daisuke Mori, Yuko Okamoto …

Molecular psychiatry, 25(8) 1849-1858, Aug, 2020 Peer-reviewed
ARHGAP10, which encodes Rho GTPase-activating protein 10, is a novel gene for schizophrenia risk.

Mariko Sekiguchi, Akira Sobue, Itaru Kushima, Chenyao Wang, Yuko Arioka, Hidekazu Kato, Akiko Kodama, Hisako Kubo, Norimichi Ito, Masahito Sawahata …

Translational psychiatry, 10(1) 247-247, Jul 22, 2020 Peer-reviewed
Generation and analysis of novel Reln-deleted mouse model corresponding to exonic Reln deletion in schizophrenia.

Masahito Sawahata, Daisuke Mori, Yuko Arioka, Hisako Kubo, Itaru Kushima, Kanako Kitagawa, Akira Sobue, Emiko Shishido, Mariko Sekiguchi, Akiko Kodama …

Psychiatry and clinical neurosciences, 74(5) 318-327, May, 2020 Peer-reviewed
Cell body shape and directional movement stability in human-induced pluripotent stem cell-derived dopaminergic neurons.

Yuko Arioka, Emiko Shishido, Itaru Kushima, Daisuke Mori, Norio Ozaki

Scientific reports, 10(1) 5820-5820, Apr 2, 2020 Peer-reviewed
Characterization of a schizophrenia patient with a rare RELN deletion by combining genomic and patient-derived cell analyses.

Yuko Arioka, Akihiro Hirata, Itaru Kushima, Branko Aleksic, Daisuke Mori, Norio Ozaki

Schizophrenia research, Dec 14, 2019 Peer-reviewed
In vitro modeling of the bipolar disorder and schizophrenia using patient-derived induced pluripotent stem cells with copy number variations of PCDH15 and RELN.

Ishii T, Ishikawa M, Fujimori K, Maeda T, Kushima I, Arioka Y, Mori D, Nakatake Y, Yamagata B, Nio S …

eNeuro, 6(5) ENEURO.0403-18.2019, Sep, 2019 Peer-reviewed
Quantitative facial expression analysis revealed the efficacy and time course of oxytocin in autism.

Keiho Owada, Takashi Okada, Toshio Munesue, Miho Kuroda, Toru Fujioka, Yota Uno, Kaori Matsumoto, Hitoshi Kuwabara, Daisuke Mori, Yuko Okamoto …

Brain : a journal of neurology, 142(7) 2127-2136, Jul 1, 2019
Proteomic analysis of lymphoblastoid cell lines from schizophrenic patients.

Akira Yoshimi, Shinnosuke Yamada, Shohko Kunimoto, Branko Aleksic, Akihiro Hirakawa, Mitsuki Ohashi, Yurie Matsumoto, Kazuhiro Hada, Norimichi Itoh, Yuko Arioka …

Translational psychiatry, 9(1) 126-126, Apr 22, 2019 Peer-reviewed
Comparative Analyses of Copy-Number Variation in Autism Spectrum Disorder and Schizophrenia Reveal Etiological Overlap and Biological Insights.

Itaru Kushima, Branko Aleksic, Masahiro Nakatochi, Teppei Shimamura, Takashi Okada, Yota Uno, Mako Morikawa, Kanako Ishizuka, Tomoko Shiino, Hiroki Kimura …

Cell reports, 24(11) 2838-2856, Sep 11, 2018 Peer-reviewed

Misc.

自閉スペクトラム症ゲノム解析の現状-当事者・家族の期待に応える成果を目指して-

加藤秀一, 有岡祐子, 有岡祐子, 尾崎紀夫, 尾崎紀夫

児童青年精神医学とその近接領域, 62(4), 2021
自閉スペクトラム症のゲノム研究と今後の展望

有岡祐子, 久島周, 尾崎紀夫

臨床精神医学, 44 1341-1348, 2015 Invited
iPS細胞の新展開 DNA脱メチル化関連因子Tetの細胞内局在制御機構の解析

有岡祐子, 渡辺亮, 齋藤邦明, 山田泰広

Cytometry Research, 22(Suppl.) 35-35, Jun, 2012
Indoleamine‐2,3‐dioxygenase(IDO)の抑制によるマウスウイルス性心筋炎の病態改善

吉永佳世, 星雅人, 松本圭史, 有岡祐子, 森口達郎, 村上由希, 山本康子, 竹村正男, 清島満, 斉藤邦明

臨床化学, 39(Suppl.1) 132-132, Jul 31, 2010
ウイルス性心筋炎における新規免疫制御因子としてのIDOの役割に関する研究

松本圭史, 有岡祐子, 山本康子, 竹田真由, 舩渡忠男, 星雅人, 竹村正男, 伊藤康弘, 清島満, 斉藤邦明

臨床化学, 38(Suppl.1) 143-143, Jul, 2009

Books and Other Publications

ゲノム解析を基盤とした自閉スペクトラム症・統合失調症のiPS細胞研究

有岡祐子, 久島周, 森大輔, 尾崎紀夫

日本生物学的精神医学会誌, Sep, 2018
Current and Future Genetic Study for Autism Spectrum Disorder

Yuko Arioka, Itaru Kushima, Norio Ozaki

2015

Presentations

患者iPS細胞で明らかにする神経精神疾患の細胞・分子病理

有岡祐子

第63回日本神経化学会大会, Sep 10, 2020
染色体22q11.2欠失症候群患者ドパミン神経細胞ではキナーゼタンパク質PERK依存的脆弱性が生じる

有岡祐子

第50回日本神経精神薬理学会・第42回日本生物学的精神医学会・第４回日本精神薬学会総会・学術集会（NPBPPP 2020 合同年会）
染色体22q11.2欠失症候群患者iPS細胞を用いた精神疾患の病態解明研究

有岡祐子

第50回日本神経精神薬理学会・第42回日本生物学的精神医学会・第４回日本精神薬学会総会・学術集会（NPBPPP 2020 合同年会）, Aug 22, 2020
Single-cell trajectory analysis of human iPS cell-derived neurons carrying a rare RELN deletion.

有岡祐子

第57回日本生物物理学会, Sep 24, 2019
染色体22q11.2欠失患者iPS細胞由来の神経細胞はストレス応答機構に依存した脆弱性を有する

有岡祐子

第41回JSBP, Jun, 2019
Human iPSC-derived brain organoid as a novel tool to analyze both glial & neuronal cell development and function.

Yuko Arioka, Akihiro Hirata, Norio Ozaki

Dec 1, 2018
稀なゲノム変異（バリアント）を有する患者iPS細胞に着目した精神疾患研究

有岡祐子

第28回日本臨床精神神経薬理学会·第48回日本神経精神薬理学会合同年会, Nov 15, 2018 Invited
Understanding the pathophysiology of mental disorders using patient-derived iPS cells

Yuko Arioka

Oct 28, 2018 Invited
Using induced pluripotent stem cells for psychiatric research based on rare genetic variants ―utilizing genomic research technologies and results－

Yuko Arioka, Itaru Kushima, Daisuke Mori, Norio Ozaki

Sep 30, 2017 Invited

Teaching Experience

2020 - Present

先端医療開発論 (藤田医科大学)
2020 - Present

生涯健康と医学 (名古屋大学)

Professional Memberships

Research Projects

中脳から捉える22q11.2欠失症候群患者の脳内分子・細胞病態

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2022 - Mar, 2025

有岡祐子
Production of a bipolar model mice and clarification of the neuronal mechanism of the manic switch

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2024
染色体22q11.2欠失がもたらす脳内ストレス脆弱性機構の解明

基盤（C）, 日本学術振興会: 科学研究費助成事業, Apr, 2019 - Mar, 2022

有岡祐子
Interstellar Initiative 2019

Interstellar Initiative, AMED/NYAS, Jul, 2019 - Mar, 2020

Yuko Arioka
22q11.2欠失細胞から捉える統合失調症の病態解明

若手研究（B）, 日本学術振興会: 科学研究費助成事業, Apr, 2016 - Mar, 2020

有岡祐子
iPS細胞樹立過程には組織ごとの特異的ルートがあるのか

若手研究（B), 日本学術振興会: 科学研究費助成事業, Apr, 2014 - Mar, 2017

有岡祐子
iPS細胞樹立過程には組織ごとの特異的な指向性があるのか

研究活動スタート支援, 日本学術振興会: 科学研究費助成事業, Sep, 2013 - Mar, 2014

有岡祐子

Industrial Property Rights

特願2018-194682 抗精神病薬及びその用途

尾崎紀夫, 山田清文, 永井拓, 森大輔, 有岡祐子, 久島周
特願2018- 42409 細胞内カルシウム動態評価系

竹本さやか, 堀金慎一郎, 尾崎紀夫, 有岡祐子
特願2018- 35758 薬剤評価方法

尾崎紀夫, 有岡祐子, 東島恵美子, 森大輔, 久島周
特願2017- 82600 ドパミン神経細胞の調製方法

尾崎紀夫, 有岡祐子, 森大輔, 久島周