論文

査読有り 国際誌
2020年5月4日

Afadin regulates actomyosin organization through αE-catenin at adherens junctions.

The Journal of cell biology
  • Shotaro Sakakibara
  • ,
  • Kiyohito Mizutani
  • ,
  • Ayumu Sugiura
  • ,
  • Ayuko Sakane
  • ,
  • Takuya Sasaki
  • ,
  • Shigenobu Yonemura
  • ,
  • Yoshimi Takai

219
5
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1083/jcb.201907079

Actomyosin-undercoated adherens junctions are critical for epithelial cell integrity and remodeling. Actomyosin associates with adherens junctions through αE-catenin complexed with β-catenin and E-cadherin in vivo; however, in vitro biochemical studies in solution showed that αE-catenin complexed with β-catenin binds to F-actin less efficiently than αE-catenin that is not complexed with β-catenin. Although a "catch-bond model" partly explains this inconsistency, the mechanism for this inconsistency between the in vivo and in vitro results remains elusive. We herein demonstrate that afadin binds to αE-catenin complexed with β-catenin and enhances its F-actin-binding activity in a novel mechanism, eventually inducing the proper actomyosin organization through αE-catenin complexed with β-catenin and E-cadherin at adherens junctions.

リンク情報
DOI
https://doi.org/10.1083/jcb.201907079
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32227204
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199863

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