論文

国際誌
2020年5月29日

Malignant adenomyoepithelioma of the breast.

Surgical case reports
  • Kazuki Moro
  • ,
  • Eiko Sakata
  • ,
  • Asa Nakahara
  • ,
  • Hideki Hashidate
  • ,
  • Emmanuel Gabriel
  • ,
  • Haruhiko Makino

6
1
開始ページ
118
終了ページ
118
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1186/s40792-020-00881-2

BACKGROUND: Adenomyoepithelioma (AME) of the breast is a very rare tumor and is generally considered to be benign. However, some show malignant transformation, which results in local recurrences or distant metastases. The morphological features of AME that might predict malignant potential have not been elucidated. Moreover, there is also no established multidisciplinary treatment for malignant AME aside from complete excision at an early stage. CASE PRESENTATION: A 64-year-old female diagnosed with AME of the left breast underwent lumpectomy. The surgical margins were negative. Six months after the operation, however, malignant AME recurred locally in the left breast. MRI showed multiple masses, which invaded the skin. A left mastectomy with axillary lymph node dissection was performed. Additional areas of AME were found in about one third of the entire breast. Eight months after the mastectomy, lung metastases were detected. She underwent chemotherapy with fluorouracil, epirubicin, and cyclophosphamide (FEC) for 9 cycles with little response. Lung metastasectomy was performed. Nine months after lung metastasectomy, the metastases were widespread to the brain, heart, and kidney; she subsequently died 2 months later. CONCLUSIONS: Malignant AME has various morphological features, and in this report, we characterize new findings from both imaging and pathology/autopsy. Malignant potency is related to the tumor size, tumor appearance, and mitoses, even if only a few. Given that ductal spread is one of the morphological features of malignant AME, it is of paramount importance to assess the surgical margins.

リンク情報
DOI
https://doi.org/10.1186/s40792-020-00881-2
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32472226
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260303
ID情報
  • DOI : 10.1186/s40792-020-00881-2
  • PubMed ID : 32472226
  • PubMed Central 記事ID : PMC7260303

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