2012年9月15日
Synthesis of paclitaxel-BGL conjugates
Bioorganic and Medicinal Chemistry
- 巻
- 20
- 号
- 18
- 開始ページ
- 5559
- 終了ページ
- 5567
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.bmc.2012.07.031
Four kinds of symmetrically branched oligoglyceryl trimeric (BGL003)-paclitaxel conjugates and a corresponding heptameric (BGL007) conjugate were synthesized. Molecular weights of all the compounds were less than two times that of paclitaxel. The anti-tumor activity of the most water-soluble BGL003 conjugate was examined and found to be preserved in spite of the chemical modification that is displacement of the N3′-debenzoyl residue with the BGL003 succinyl residue. © 2011 Elsevier Ltd. All rights reserved.
- リンク情報
- ID情報
-
- DOI : 10.1016/j.bmc.2012.07.031
- ISSN : 0968-0896
- ISSN : 1464-3391
- PubMed ID : 22892212
- SCOPUS ID : 84866251635