2017年5月
Helianthus tuberosus (Jerusalem artichoke) tubers improve glucose tolerance and hepatic lipid profile in rats fed a high-fat diet
ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE
- ,
- ,
- ,
- ,
- ,
- ,
- 巻
- 10
- 号
- 5
- 開始ページ
- 418
- 終了ページ
- 422
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.apjtm.2017.03.028
- 出版者・発行元
- ELSEVIER SCI LTD
Objective: To analyze the effects of feeding Helianthus tuberosus (HT) tubers on glucose tolerance and lipid profile in rats fed a high-fat diet (HFD). Methods: A normal HFD or HFD including 10 w/w% HT tubers (HFD + HT) was fed to F334/Jcl rats. After 10 weeks, organ weights, glucose tolerance, and lipid profile were analyzed. Results: The body weight. liver weight, and epidermal fat content in the HFD group were higher than those of the normal group, and similar to those of the HFD + HT group. The oral glucose tolerance test at 10 weeks revealed that the blood glucose level 30 minutes after beginning the test in the HFD + FIT group was significantly lower than that in the HFD group. Liver triglyceride and total cholesterol levels in the HFD + HT group were significantly lower than those in the HFD group. Fecal triglyceride and total cholesterol levels in the FWD + HT group were higher than those in the HFD group. Histological analyses revealed that fat and glycogen accumulation increased in the HFD group, but decreased in the HFD + HT group. Conclusions: These results indicate that HT tubers have anti-fatty liver effects based on improvements in glucose tolerance and the hepatic lipid profile.
- リンク情報
- ID情報
-
- DOI : 10.1016/j.apjtm.2017.03.028
- ISSN : 1995-7645
- PubMed ID : 28647180
- Web of Science ID : WOS:000402360700003