2014年1月
Olfactory Receptor and Neural Pathway Responsible for Highly Selective Sensing of Musk Odors
NEURON
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- 巻
- 81
- 号
- 1
- 開始ページ
- 165
- 終了ページ
- 178
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.neuron.2013.10.021
- 出版者・発行元
- CELL PRESS
Musk odorants are used widely in cosmetic industries because of their fascinating animalic scent. However, how this aroma is perceived in the mammalian olfactory system remains a great mystery. Here, we show that muscone, one musk odor secreted by various animals from stink glands, activates a few glomeruli clustered in a neuroanatomically unique anteromedial olfactory bulb. The muscone-responsive glomeruli are highly specific to macrocyclic ketones; interestingly, other synthetic musk odorants with nitro or polycyclic moieties or ester bonds activate distinct but nearby glonneruli. Anterodorsal bulbar lesions cause muscone anosmia, suggesting that this region is involved in muscone perception. Finally, we identified the mouse olfactory receptor, MOR215-1, that was a specific muscone receptor expressed by neurons innervating the muscone-responsive anteromedial glomeruli and also the human muscone receptor, OR5AN1. The current study documents the olfactory neural pathway in mice that senses and transmits musk signals from receptor to brain.
- リンク情報
- ID情報
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- DOI : 10.1016/j.neuron.2013.10.021
- ISSN : 0896-6273
- eISSN : 1097-4199
- PubMed ID : 24361078
- Web of Science ID : WOS:000329559000017