論文

査読有り 国際誌
2021年2月16日

A Marine Carotenoid of Fucoxanthinol Accelerates the Growth of Human Pancreatic Cancer PANC-1 Cells.

Nutrition and cancer
  • Masaru Terasaki
  • Shouta Takahashi
  • Ryuta Nishimura
  • Atsuhito Kubota
  • Hiroyuki Kojima
  • Tohru Ohta
  • Junichi Hamada
  • Yasuhiro Kuramitsu
  • Hayato Maeda
  • Kazuo Miyashita
  • Mami Takahashi
  • Michihiro Mutoh
  • 全て表示

74
1
開始ページ
1
終了ページ
16
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1080/01635581.2020.1863994
出版者・発行元
ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD

Fucoxanthin and its metabolite fucoxanthinol (FxOH), highly polar xanthophylls, exert strong anticancer effects against many cancer cell types. However, the effects of Fx and FxOH on pancreatic cancer, a high mortality cancer, remain unclear. We herein investigated whether FxOH induces apoptosis in human pancreatic cancer cells. FxOH (5.0 μmol/L) significantly promoted the growth of human pancreatic cancer PANC-1 cells, but induced apoptosis in human colorectal cancer DLD-1 cells. A microarray-based gene analysis revealed that the gene sets of cell cycle, adhesion, PI3K/AKT, MAPK, NRF2, adipogenesis, TGF-β, STAT, and Wnt signals in PANC-1 cells were markedly altered by FxOH. A western blot analysis showed that FxOH up-regulated the expression of integrin β1 and PPARγ as well as the activation of pFAK(Tyr397), pPaxillin(Tyr31), and pAKT(Ser473) in PANC-1 cells, but exerted the opposite effects in DLD-1 cells. Moreover, the expression of FYN, a downstream target of integrin subunits, was up-regulated (7.4-fold by qPCR) in FxOH-treated PANC-1 cells. These results suggest that FxOH accelerates the growth of PANC-1 cells by up-regulating the expression of integrin β1, FAK, Paxillin, FYN, AKT, and PPARγ.

リンク情報
DOI
https://doi.org/10.1080/01635581.2020.1863994
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33590779
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000618648800001&DestApp=WOS_CPL
ID情報
  • DOI : 10.1080/01635581.2020.1863994
  • ISSN : 0163-5581
  • eISSN : 1532-7914
  • PubMed ID : 33590779
  • Web of Science ID : WOS:000618648800001

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