角南明彦 (Akihiko Sunami) - マイポータル

基本情報

所属: 国際医療福祉大学薬学部教授

学位: 薬学博士(岡山大学大学院自然科学研究科)

J-GLOBAL ID: 201801012194906559
researchmap会員ID: B000329525

研究キーワード

イオンチャネル

研究分野

ライフサイエンス / 薬系衛生、生物化学 /

論文

Mexiletine Block of Voltage-Gated Sodium Channels: Isoform- and State-Dependent Drug-Pore Interactions.

Nakagawa H, Munakata T, Sunami A

Molecular pharmacology 95(3) 236-244 2019年3月査読有り
Drug-Binding Sites of Cardiac Sodium Channel

Akihiko Sunami

journal of arrhythmia 27(4) 241 2011年査読有り
A Genetically Encoded Bioluminescent Indicator for the Sodium Channel Activity in Living Cells

Asami Kaihara, Akihiko Sunami, Junko Kurokawa, Tetsushi Furukawa

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 131(12) 4188-+ 2009年4月査読有り
The E1784K mutation in SCN5A is associated with mixed clinical phenotype of type 3 long QT syndrome

Naomasa Makita, Elijah Behr, Wataru Shimizu, Minoru Horie, Akihiko Sunami, Lia Crotti, Eric Schulze-Bahr, Shigetomo Fukuhara, Naoki Mochizuki, Takeru Makiyama …

JOURNAL OF CLINICAL INVESTIGATION 118(6) 2219-2229 2008年6月査読有り
Accessibility of mid-segment domain IVS6 residues of the voltage-gated Na+ channel to methanethiosulfonate reagents

A Sunami, A Tracey, IW Glaaser, GM Lipkind, DA Hanck, HA Fozzard

JOURNAL OF PHYSIOLOGY-LONDON 561(2) 403-413 2004年12月査読有り
Unexpected mexiletine responses of a mutant cardiac Na+ channel implicate the selectivity filter as a structural determinant of antiarrhythmic drug access

K Sasaki, N Makita, A Sunami, H Sakurada, N Shirai, H Yokoi, A Kimura, N Tohse, M Hiraoka, A Kitabatake

MOLECULAR PHARMACOLOGY 66(2) 330-336 2004年8月査読有り
Electrophysiological effects of ginseng and ginsenoside Re in guinea pig ventricular myocytes

CX Bai, A Sunami, T Namiki, T Sawanobori, T Furukawa

EUROPEAN JOURNAL OF PHARMACOLOGY 476(1-2) 35-44 2003年8月査読有り
Involvement of local anesthetic binding sites on IVS6 of sodium channels in fast and slow inactivation

CX Bai, IW Glaaser, T Sawanobori, A Sunami

NEUROSCIENCE LETTERS 337(1) 41-45 2003年1月査読有り
Cardiac-specific external paths for lidocaine, defined by isoform-specific residues, accelerate recovery from use-dependent block

PJ Lee, A Sunami, HA Fozzard

CIRCULATION RESEARCH 89(11) 1014-1021 2001年11月査読有り
Structural and gating changes of the sodium channel induced by mutation of a residue in the upper third of IVS6, creating an external access path for local anesthetics

A Sunami, IW Glasser, HA Fozzard

MOLECULAR PHARMACOLOGY 59(4) 684-691 2001年4月査読有り
A critical residue for isoform difference in tetrodotoxin affinity is a molecular determinant of the external access path for local anesthetics in the cardiac sodium channel

A Sunami, IW Glaaser, HA Fozzard

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 97(5) 2326-2331 2000年2月査読有り
Sodium channel selectivity filter regulates antiarrhythmic drug binding

A Sunami, SC Dudley, HA Fozzard

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 94(25) 14126-14131 1997年12月査読有り
Blockade of cardiac Na+ channels by a charged class I antiarrhythmic agent, bisaramil: Possible interaction of the drug with a pre-open closed state

A Sunami, M Hiraoka

EUROPEAN JOURNAL OF PHARMACOLOGY 312(2) 245-255 1996年9月査読有り
INTERACTION BETWEEN EXTERNAL NA+ AND MEXILETINE ON NA+ CHANNEL IN GUINEA-PIG VENTRICULAR MYOCYTES

M ONO, A SUNAMI, M HIRAOKA

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 431(1) 101-109 1995年11月査読有り
Voltage- and frequency-dependent modulation of L-type Ca2+ channel by MPC-1304, a novel calcium antagonist in guinea-pig hearts

A Sunami, T Kanno, A Kanda

ARCHIVES INTERNATIONALES DE PHARMACODYNAMIE ET DE THERAPIE 330(2) 151-164 1995年9月査読有り
SYNTHESIS AND BIOLOGICAL-ACTIVITY OF THE METABOLITES OF SYN-3-ETHYL-7-METHYL-3,7-DIAZABICYCLO[3.3.1]NON-9-YL 4-CHLOROBENZOATE HYDROCHLORIDE

YAMAWAKI, I, SW BUKOVAC, A SUNAMI

CHEMICAL & PHARMACEUTICAL BULLETIN 42(11) 2365-2369 1994年11月査読有り
EXTERNAL PH MODIFIES SODIUM-CHANNEL BLOCK BY MEXILETINE IN GUINEA-PIG VENTRICULAR MYOCYTES

M ONO, A SUNAMI, T SAWANOBORI, M HIRAOKA

CARDIOVASCULAR RESEARCH 28(7) 973-979 1994年7月査読有り
USE-DEPENDENT BLOCK OF NA+ CURRENTS BY MEXILETINE AT THE SINGLE-CHANNEL LEVEL IN GUINEA-PIG VENTRICULAR MYOCYTES

A SUNAMI, Z FAN, T SAWANOBORI, M HIRAOKA

BRITISH JOURNAL OF PHARMACOLOGY 110(1) 183-192 1993年9月査読有り
USE-DEPENDENT BLOCK OF CA-2+ CURRENT BY MORICIZINE IN GUINEA-PIG VENTRICULAR MYOCYTES - A POSSIBLE IONIC MECHANISM OF ACTION-POTENTIAL SHORTENING

T YAMANE, A SUNAMI, T SAWANOBORI, M HIRAOKA

BRITISH JOURNAL OF PHARMACOLOGY 108(3) 812-818 1993年3月査読有り
PROPERTIES OF VERATRIDINE-MODIFIED SINGLE NA+ CHANNELS IN GUINEA-PIG VENTRICULAR MYOCYTES

A SUNAMI, T SASANO, A MATSUNAGA, Z FAN, T SAWANOBORI, M HIRAOKA

AMERICAN JOURNAL OF PHYSIOLOGY 264(2) H454-H463 1993年2月査読有り

もっとみる

MISC

抗不整脈薬によるヒト心筋Naチャネル抑制作用のチャネルポア分子構造基盤

中川博揮, 宗像達夫, 角南明彦

日本薬理学会関東部会プログラム・要旨集 134th 63 2016年
A GENETICALLY ENCODED BIOLUMINESCENT INDICATOR FOR THE SODIUM CHANNEL IN LIVING CELLS

Asami Kaihara, Akihiko Sunami, Junko Kurokawa, Tetsushi Furukawa

JOURNAL OF PHYSIOLOGICAL SCIENCES 59 250-250 2009年
An SCN5A Mutation Associated With Idiopathic Ventricular Fibrillation Alters The Na^+ Channel Pore Structure And Responses To Antiarrhythmic Drugs

Sasaki Koji, Makita Naomasa, Shirai Nobumasa, Yokoi Hisataka, Kitabatake Akira, Sunami Akihiko, Kimura Akinori, Hiraoka Masayasu

Circulation journal : official journal of the Japanese Circulation Society 66 118-118 2002年3月31日
Cysteine scanning analysis of domain IVS6 in sodium channel

A Sunami, T Sawanobori, HA Fozzard

JAPANESE JOURNAL OF PHARMACOLOGY 88 215P-215P 2002年
The structure and orientation of domain IVS6 in sodium channel determined by cysteine scanning mutagenesis

A Sunami, IW Glaaser, GM Lipkind, HA Fozzard

CIRCULATION 104(17) 216-216 2001年10月
Isoform-specific residue affects pharmacokinetics of lidocaine in the voltage-gated Na+ channel.

PJ Lee, A Sunami, HA Fozzard

BIOPHYSICAL JOURNAL 80(1) 227A-227A 2001年1月
Characterizing the structure and orientation of domain IVS6 of sodium channel.

A Sunami, IW Glaaser, GM Lipkind, HA Fozzard

BIOPHYSICAL JOURNAL 80(1) 231A-231A 2001年1月
Cardiac isoform-specific residue influences pharmacokinetics of lidocaine in the voltage-gated Na+ channel.

PJ Lee, A Sunami, HA Fozzard

CIRCULATION 102(18) 264-264 2000年10月
A critical residue for isoform difference in tetrodotoxin affinity is a molecular determinants of the external access path for local anesthetics through the cardiac sodium channel pore.

A Sunami, IW Glaaser, SC Dudley, HA Fozzard

BIOPHYSICAL JOURNAL 78(1) 86A-86A 2000年1月
Local anesthetic antiarrhythmic drugs block sodium channels from the outside: Critical role of cysteine in the outer vestibule

A Sunami, IW Glaaser, HA Fozzard

CIRCULATION 100(18) 278-278 1999年11月
Characterizing structural rearrangement of the sodium channel outer vestibule induced by S6 mutants.

A Sunami, G Lipkind, IW Glaaser

BIOPHYSICAL JOURNAL 76(1) A81-A81 1999年1月
A mutation of the sodium channel suggesting that domain IV S6 contributes to the outer vestibule

A Sunami, SC Dudley, G Lipkind, HA Fozzard

BIOPHYSICAL JOURNAL 74(2) A398-A398 1998年2月
Role of selectivity filter region of the sodium channel in local anesthetic block.

A Sunami, SC Dudley, G Lipkind, HA Fozzard

BIOPHYSICAL JOURNAL 72(2) THP68-THP68 1997年2月
Mutations in the selectivity filter region of the sodium channel alter lidocaine block

A Sunami, SC Dudley, JW Kyle, HA Fozzard

CIRCULATION 94(8) 1665-1665 1996年10月
Moricizineの心室筋活動電位に対する作用とそのイオン機序

山根禎一, 角南明彦, 沢登徹, 平岡昌和

Japanese circulation journal 56 114-114 1992年3月1日
EFFECTS OF HISTAMINE AND ANTIHISTAMINES ON THE ACOUSTICALLY EVOKED-POTENTIALS RECORDED FROM THE AUDITORY-CORTEX AND MIDBRAIN RETICULAR-FORMATION

A SUNAMI, C KAMEI, K TASAKA

FOLIA PHARMACOLOGICA JAPONICA 82(2) P100-P100 1983年
EPILEPTOGENIC ACTIVITY OF CEPHALOSPORINS OBSERVED IN RATS AND ITS INHIBITION BY CERTAIN ANTICONVULSANTS

C KAMEI, N IKEGAMI, A SUNAMI, K TASAKA

FOLIA PHARMACOLOGICA JAPONICA 80(3) P39-P39 1982年

書籍等出版物

Advances in Health and Disease (vol. 63)

Sunami, A, Munakata, T (担当:分担執筆, 範囲:Structural pharmacology of antiarrhythmic drug interactions with the voltage-gated sodium channels)

Nova Science 2023年2月
Encyclopedia of Molecular Pharmacology, 3rd Edition

Sunami A, Munakata T (担当:分担執筆, 範囲:Local Anaesthetics)

Springer 2021年4月
不整脈学

角南明彦 (担当:共著, 範囲:心筋の電気生理 Na電流)

南江堂 2012年

講演・口頭発表等

Differences of pore structures between prokaryotic and eukaryotic voltage-gated sodium channels

角南明彦

Biophysical Society Annual Meeting 2015年2月10日招待有り
Drug-binding sites of cardiac sodium channel

角南明彦

4th Asia Pacific Heart Rhythm Society Scientific Session 2011年9月20日招待有り

共同研究・競争的資金等の研究課題

Naチャネルポア内側部の構造決定

科研費基盤研究C 2002年 - 2003年

角南明彦

角南明彦

基本情報

研究キーワード

研究分野

論文

MISC

書籍等出版物

講演・口頭発表等

共同研究・競争的資金等の研究課題

メニュー

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