2012年4月
Liposome Solubilization Induced by Surfactant Molecules in a Microchip
ANALYTICAL SCIENCES
- ,
- ,
- ,
- ,
- 巻
- 28
- 号
- 4
- 開始ページ
- 339
- 終了ページ
- 343
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.2116/analsci.28.339
- 出版者・発行元
- JAPAN SOC ANALYTICAL CHEMISTRY
The dynamics of liposome solubilization was monitored by dynamic light scattering and optical microscopy. A newly designed Y-shape microchannel connected to a room was incorporated into a microchip and the reaction processes of the liposome suspension and surfactant solution were observed in the room after mixing the two fluids and stopping the flow. By using this microchip, we succeeded in real-time monitoring of liposome solubilization and the following dynamic processes of solubilization were proposed: 1) Deformed liposomes become spherical. 2) The liposome size increases until the surfactant/liposome ratio in the liposome membrane reaches a threshold value. 3) Mixed micelles of surfactants and phospholipids are released and the liposomes collapse.
- リンク情報
- ID情報
-
- DOI : 10.2116/analsci.28.339
- ISSN : 0910-6340
- J-Global ID : 201202250562623934
- Web of Science ID : WOS:000303294700005