Atsuo T. Sasaki

J-GLOBAL         Last updated: Oct 18, 2018 at 04:55
 
Avatar
Name
Atsuo T. Sasaki
E-mail
atsuo.sasakiuc.edu
ORCID ID
0000-0003-2963-4501

Research Areas

 
 
  • Biological Science / Molecular biology / Metabolism, Energy regulation, Signal Transduction

Academic & Professional Experience

 
Oct 2018
 - 
Today
Project Professor, Keio University
 
Sep 2016
 - 
Today
Associate Professor, University of Cincinnati College of Medicine
 
Jul 2012
 - 
Aug 2016
Assistant Professor, University of Cincinnati College of Medicine
 
Apr 2010
 - 
Jun 2012
Instructor, Systems Biology, Harvard Medical School
 
Jun 2012
 - 
Jan 2010
Genentech Special Fellow, Systems Biology, Harvard Medical School
 

Education

 
Mar 2001
 - 
Apr 1997
School of Medicine, Kurume University
 
Apr 1995
 - 
Mar 1997
University of Hiroshima
 
Apr 1991
 - 
Mar 1995
Science University of Tokyo
 

Published Papers

 
Su R, Dong L, Li C, Nachtergaele S, Wunderlich M, Qing Y, Deng X, Wang Y, Weng X, Hu C, Yu M, Skibbe J, Dai Q, Zou D, Wu T, Yu K, Weng H, Huang H, Ferchen K, Qin X, Zhang B, Qi J, Sasaki AT, Plas DR, Bradner JE, Wei M, Marcucci G, Jiang X, Mulloy JC, Jin J, He C, Chen J
Cell   172(1-2) 90-105.e23   Jan 2018   [Refereed]
Liu H, Feng X, Ennis KN, Behrmann CA, Sarma P, Jiang TT, Kofuji S, Niu L, Stratton Y, Thomas HE, Yoon SO, Sasaki AT, Plas DR
Cell reports   18(9) 2088-2095   Feb 2017   [Refereed]
Kim SM, Roy SG, Chen B, Nguyen TM, McMonigle RJ, McCracken AN, Zhang Y, Kofuji S, Hou J, Selwan E, Finicle BT, Nguyen TT, Ravi A, Ramirez MU, Wiher T, Guenther GG, Kono M, Sasaki AT, Weisman LS, Potma EO, Tromberg BJ, Edwards RA, Hanessian S, Edinger AL
The Journal of clinical investigation   126(11) 4088-4102   Nov 2016   [Refereed]
Takeuchi K, Senda M, Lo YH, Kofuji S, Ikeda Y, Sasaki AT, Senda T
The FEBS journal   283(19) 3556-3562   Oct 2016   [Refereed]
Sumita K, Lo YH, Takeuchi K, Senda M, Kofuji S, Ikeda Y, Terakawa J, Sasaki M, Yoshino H, Majd N, Zheng Y, Kahoud ER, Yokota T, Emerling BM, Asara JM, Ishida T, Locasale JW, Daikoku T, Anastasiou D, Senda T, Sasaki AT
Molecular cell   61(2) 187-198   Jan 2016   [Refereed]
Sasaki AT
The Keio journal of medicine   65(1) 21   2016   [Refereed]
Davis MI, Sasaki AT, Simeonov A
Methods in molecular biology (Clifton, N.J.)   1376 1-9   2016   [Refereed]
Sumita K, Yoshino H, Sasaki M, Majd N, Kahoud ER, Takahashi H, Takeuchi K, Kuroda T, Lee S, Charest PG, Takeda K, Asara JM, Firtel RA, Anastasiou D, Sasaki AT
The Journal of biological chemistry   289(7) 3950-3959   Feb 2014   [Refereed]
Baker R, Wilkerson EM, Sumita K, Isom DG, Sasaki AT, Dohlman HG, Campbell SL
The Journal of biological chemistry   288(52) 36856-36862   Dec 2013   [Refereed]
Emerling BM, Hurov JB, Poulogiannis G, Tsukazawa KS, Choo-Wing R, Wulf GM, Bell EL, Shim HS, Lamia KA, Rameh LE, Bellinger G, Sasaki AT, Asara JM, Yuan X, Bullock A, Denicola GM, Song J, Brown V, Signoretti S, Cantley LC
Cell   155(4) 844-857   Nov 2013   [Refereed]
Baker R, Lewis SM, Sasaki AT, Wilkerson EM, Locasale JW, Cantley LC, Kuhlman B, Dohlman HG, Campbell SL
Nature structural & molecular biology   20(1) 46-52   Jan 2013   [Refereed]
Davis MI, Sasaki AT, Shen M, Emerling BM, Thorne N, Michael S, Pragani R, Boxer M, Sumita K, Takeuchi K, Auld DS, Li Z, Cantley LC, Simeonov A
PloS one   8(1) e54127   2013   [Refereed]
Subramani A, Alsidawi S, Jagannathan S, Sumita K, Sasaki AT, Aronow B, Warnick RE, Lawler S, Driscoll JJ
Scientific reports   3 2392   2013   [Refereed]
Fujimura K, Sasaki AT, Anderson P
Nucleic acids research   40(16) 8099-8110   Sep 2012   [Refereed]
Hanai J, Doro N, Sasaki AT, Kobayashi S, Cantley LC, Seth P, Sukhatme VP
Journal of cellular physiology   227 1709-1720   Apr 2012   [Refereed]
Garcia-Cao I, Song MS, Hobbs RM, Laurent G, Giorgi C, de Boer VC, Anastasiou D, Ito K, Sasaki AT, Rameh L, Carracedo A, Vander Heiden MG, Cantley LC, Pinton P, Haigis MC, Pandolfi PP
Cell   149 49-62   Mar 2012   [Refereed]
Anastasiou D, Poulogiannis G, Asara JM, Boxer MB, Jiang JK, Shen M, Bellinger G, Sasaki AT, Locasale JW, Auld DS, Thomas CJ, Vander Heiden MG, Cantley LC
Science (New York, N.Y.)   334(6060) 1278-1283   Dec 2011   [Refereed]
Locasale JW, Grassian AR, Melman T, Lyssiotis CA, Mattaini KR, Bass AJ, Heffron G, Metallo CM, Muranen T, Sharfi H, Sasaki AT, Anastasiou D, Mullarky E, Vokes NI, Sasaki M, Beroukhim R, Stephanopoulos G, Ligon AH, Meyerson M, Richardson AL, Chin L, Wagner G, Asara JM, Brugge JS, Cantley LC, Vander Heiden MG
Nature genetics   43(9) 869-874   Jul 2011   [Refereed]
Wang XS, Shankar S, Dhanasekaran SM, Ateeq B, Sasaki AT, Jing X, Robinson D, Cao Q, Prensner JR, Yocum AK, Wang R, Fries DF, Han B, Asangani IA, Cao X, Li Y, Omenn GS, Pflueger D, Gopalan A, Reuter VE, Kahoud ER, Cantley LC, Rubin MA, Palanisamy N, Varambally S, Chinnaiyan AM
Cancer discovery   1 35-43   Jun 2011   [Refereed]
Tsou P, Zheng B, Hsu CH, Sasaki AT, Cantley LC
Cell metabolism   13 476-486   Apr 2011   [Refereed]
Sasaki AT, Carracedo A, Locasale JW, Anastasiou D, Takeuchi K, Kahoud ER, Haviv S, Asara JM, Pandolfi PP, Cantley LC
Science signaling   4 ra13   Mar 2011   [Refereed]
Charest PG, Shen Z, Lakoduk A, Sasaki AT, Briggs SP, Firtel RA
Developmental cell   18(5) 737-749   May 2010   [Refereed]
Sasaki AT, Firtel RA
Methods in molecular biology (Clifton, N.J.)   571 333-348   2009   [Refereed]
Carracedo A, Ma L, Teruya-Feldstein J, Rojo F, Salmena L, Alimonti A, Egia A, Sasaki AT, Thomas G, Kozma SC, Papa A, Nardella C, Cantley LC, Baselga J, Pandolfi PP
The Journal of clinical investigation   118 3065-3074   Sep 2008   [Refereed]
Sasaki AT, Janetopoulos C, Lee S, Charest PG, Takeda K, Sundheimer LW, Meili R, Devreotes PN, Firtel RA
The Journal of cell biology   178(2) 185-191   Jul 2007   [Refereed]
Takeda K, Sasaki AT, Ha H, Seung HA, Firtel RA
The Journal of biological chemistry   282(16) 11874-11884   Apr 2007   [Refereed]
Sasaki AT, Firtel RA
European journal of cell biology   85 873-895   Sep 2006   [Refereed]
Lee S, Comer FI, Sasaki A, McLeod IX, Duong Y, Okumura K, Yates JR 3rd, Parent CA, Firtel RA
Molecular biology of the cell   16 4572-4583   Oct 2005   [Refereed]
Taketomi T, Yoshiga D, Taniguchi K, Kobayashi T, Nonami A, Kato R, Sasaki M, Sasaki A, Ishibashi H, Moriyama M, Nakamura K, Nishimura J, Yoshimura A
Nature neuroscience   8 855-857   Jul 2005   [Refereed]
Meili R, Sasaki AT, Firtel RA
Nature cell biology   7(4) 334-335   Apr 2005   [Refereed]
Finding the way: directional sensing and cell polarization through Ras signalling.
Sasaki AT, Firtel RA
Novartis Foundation symposium   269 73-87; discussion 87   2005   [Refereed]
Kuriyama M, Taniguchi T, Shirai Y, Sasaki A, Yoshimura A, Saito N
Biochemical and biophysical research communications   325(3) 843-851   Dec 2004   [Refereed]
Nonami A, Kato R, Taniguchi K, Yoshiga D, Taketomi T, Fukuyama S, Harada M, Sasaki A, Yoshimura A
The Journal of biological chemistry   279(50) 52543-52551   Dec 2004   [Refereed]
Sasaki AT, Chun C, Takeda K, Firtel RA
The Journal of cell biology   167(3) 505-518   Nov 2004   [Refereed]
Mucosal T cells bearing TCRgammadelta play a protective role in intestinal inflammation.
Inagaki-Ohara K, Chinen T, Matsuzaki G, Sasaki A, Sakamoto Y, Hiromatsu K, Nakamura-Uchiyama F, Nawa Y, Yoshimura A
Journal of immunology (Baltimore, Md. : 1950)   173 1390-1398   Jul 2004   [Refereed]
Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.
Sasaki A, Taketomi T, Kato R, Saeki K, Nonami A, Sasaki M, Kuriyama M, Saito N, Shibuya M, Yoshimura A
Cell cycle (Georgetown, Tex.)   2 281-282   Jul 2003   [Refereed]
Sasaki A, Taketomi T, Kato R, Saeki K, Nonami A, Sasaki M, Kuriyama M, Saito N, Shibuya M, Yoshimura A
Nature cell biology   5(5) 427-432   May 2003   [Refereed]
Endo T, Sasaki A, Minoguchi M, Joo A, Yoshimura A
Journal of biochemistry   133(1) 109-113   Jan 2003   [Refereed]
Sasaki A, Inagaki-Ohara K, Yoshida T, Yamanaka A, Sasaki M, Yasukawa H, Koromilas AE, Yoshimura A
The Journal of biological chemistry   278(4) 2432-2436   Jan 2003   [Refereed]
Lehmann U, Schmitz J, Weissenbach M, Sobota RM, Hortner M, Friederichs K, Behrmann I, Tsiaris W, Sasaki A, Schneider-Mergener J, Yoshimura A, Neel BG, Heinrich PC, Schaper F
The Journal of biological chemistry   278(1) 661-671   Jan 2003   [Refereed]
Sasaki A, Taketomi T, Wakioka T, Kato R, Yoshimura A
The Journal of biological chemistry   276(39) 36804-36808   Sep 2001   [Refereed]
Wakioka T, Sasaki A, Kato R, Shouda T, Matsumoto A, Miyoshi K, Tsuneoka M, Komiya S, Baron R, Yoshimura A
Nature   412(6847) 647-651   Aug 2001   [Refereed]
Sasaki A, Yasukawa H, Shouda T, Kitamura T, Dikic I, Yoshimura A
The Journal of biological chemistry   275(38) 29338-29347   Sep 2000   [Refereed]
Yasukawa H, Sasaki A, Yoshimura A
Annual review of immunology   18 143-164   2000   [Refereed]
Marine JC, McKay C, Wang D, Topham DJ, Parganas E, Nakajima H, Pendeville H, Yasukawa H, Sasaki A, Yoshimura A, Ihle JN
Cell   98(5) 617-627   Sep 1999   [Refereed]
Sasaki A, Yasukawa H, Suzuki A, Kamizono S, Syoda T, Kinjyo I, Sasaki M, Johnston JA, Yoshimura A
Genes to cells : devoted to molecular & cellular mechanisms   4(6) 339-351   Jun 1999   [Refereed]
Suzuki R, Sakamoto H, Yasukawa H, Masuhara M, Wakioka T, Sasaki A, Yuge K, Komiya S, Inoue A, Yoshimura A
Oncogene   17(17) 2271-2278   Oct 1998   [Refereed]
A Janus kinase inhibitor, JAB, is an interferon-gamma-inducible gene and confers resistance to interferons.
Sakamoto H, Yasukawa H, Masuhara M, Tanimura S, Sasaki A, Yuge K, Ohtsubo M, Ohtsuka A, Fujita T, Ohta T, Furukawa Y, Iwase S, Yamada H, Yoshimura A
Blood   92 1668-1676   Sep 1998   [Refereed]
Masuhara M, Sakamoto H, Matsumoto A, Suzuki R, Yasukawa H, Mitsui K, Wakioka T, Tanimura S, Sasaki A, Misawa H, Yokouchi M, Ohtsubo M, Yoshimura A
Biochemical and biophysical research communications   239(2) 439-446   Oct 1997   [Refereed]

Conference Activities & Talks

 
Role of GTP metabolism in Ovarian Cancer [Invited]
Atsuo T. Sasaki
UC-CCHMC reproductive medicine group meeting   3 Apr 2013   
Introduction of UC-Tomorrow, Japanese Research Community in Cincinnati [Invited]
Atsuo T. Sasaki
JSPS Washington DC- United Japanese Researcher Abroadh   21 Mar 2013   
A proposal of strategy for UC-BTC in next 10 years [Invited]
Atsuo T. Sasaki
University of Cincinnati, Brain Tumor Center   14 Mar 2013   
Impact of GTP metabolism on Liver Functions [Invited]
Atsuo T. Sasaki
シンシナティー小児病院・消化器センターセミナー   6 Mar 2013   
Serine metabolism and GTP biosynthesis [Invited]
Atsuo T. Sasaki
UC Signaling Group   4 Mar 2013   
The impact of GTP-­‐signaling on Cancers and Metabolic Diseases [Invited]
Atsuo T. Sasaki
University of Cincinnati, Cancer Biology Seminar   21 Feb 2013   
A Novel Regulation of GTP-Signaling in Cancers [Invited]
Atsuo T. Sasaki
University of Cincinnati, Molecular Biology, Biochemistry & Microbiology seminar   12 Feb 2013   
Impact of GTP metabolism in Brain Tumors [Invited]
Atsuo T. Sasaki
CCHMC Neuro-Oncology Seminar   5 Feb 2013   
Impact of GTP metabolism in Cancers and Metabolic diseases [Invited]
Atsuo T. Sasaki
UC-Cancer Institute: Obesity & Cancers   18 Jan 2013   
Impact of GTP metabolism in Brain Tumors [Invited]
Atsuo T. Sasaki
UC-Brain Tumor Center Seminar   2013   
新規GTPシグナル制御の癌における役割 [Invited]
Atsuo T. Sasaki
UC College of Medicien, Hematology seminar   12 Nov 2012   
Regulation of KRas by Ubiquitination [Invited]
Atsuo T. Sasaki
CCHMC Neuro-Oncology Seminar   7 Nov 2012   
Izayoi Science Meeting [Invited]
Atsuo T. Sasaki
JSPS Washington DC- United Japanese Researcher Abroadh   19 Oct 2012   
新規GTPシグナル制御機構の癌における役割 [Invited]
Atsuo T. Sasaki
UC Signaling Group   16 Oct 2012   
GTP代謝制御 [Invited]
Atsuo T. Sasaki
UC Signaling Group   16 Oct 2012   
Impact of nucleotide synthesis on genomic stability
Atsuo T. Sasaki
UC Signaling Group Meeting   1 Oct 2012   
A novel regulation of Ras in brain tumors [Invited]
Atsuo T. Sasaki
シンシナティー大・癌研究所・脳腫瘍セミナ−   10 Sep 2012   
Impact of GTP metabolism in Cancers and Metabolic diseases [Invited]
Atsuo T. Sasaki
The 39th Izayoi Science Meeting   6 Jun 2012   
Impact of GTP metabolism in Cancers and Metabolic diseases [Invited]
Atsuo T. Sasaki
Izayoi Science Meeting   24 Mar 2012   
Impact of GTP metabolism in Cancers and Metabolic diseases [Invited]
Atsuo T. Sasaki
Kyushu Univ. Bioregulation Seminar   23 Mar 2012