2015年8月10日
Quantitative activation-induced manganese-enhanced MRI reveals severity of Parkinson's disease in mice.
Scientific reports
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- 巻
- 5
- 号
- 開始ページ
- 12800
- 終了ページ
- 12800
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/srep12800
We demonstrate that activation-induced manganese-enhanced magnetic resonance imaging with quantitative determination of the longitudinal relaxation time (qAIM-MRI) reveals the severity of Parkinson's disease (PD) in mice. We first show that manganese ion-accumulation depends on neuronal activity. A highly active region was then observed by qAIM-MRI in the caudate-putamen in PD-model mice that was significantly correlated to the severity of PD, suggesting its involvement in the expression of PD symptoms.
- リンク情報
- ID情報
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- DOI : 10.1038/srep12800
- PubMed ID : 26255701
- PubMed Central 記事ID : PMC4530460