論文

査読有り
2017年11月

Light Controls Protein Localization through Phytochrome-Mediated Alternative Promoter Selection

CELL
  • Tomokazu Ushijima
  • Kousuke Hanada
  • Eiji Gotoh
  • Wataru Yamori
  • Yutaka Kodama
  • Hiroyuki Tanaka
  • Miyako Kusano
  • Atsushi Fukushima
  • Mutsutomo Tokizawa
  • Yoshiharu Y. Yamamoto
  • Yasuomi Tada
  • Yutaka Suzuki
  • Tomonao Matsushita
  • 全て表示

171
6
開始ページ
1316
終了ページ
+
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.cell.2017.10.018
出版者・発行元
CELL PRESS

Alternative promoter usage is a proteome-expanding mechanism that allows multiple pre-mRNAs to be transcribed from a single gene. The impact of this mechanism on the proteome and whether it is positively exploited in normal organismal responses remain unclear. Wefound that the plant photoreceptor phytochrome induces genome-wide changes in alternative promoter selection in Arabidopsis thaliana. Through this mechanism, protein isoforms with different N termini are produced that display lightdependent differences in localization. For instance, shade-grown plants accumulate a cytoplasmic isoform of glycerate kinase (GLYK), an essential photorespiration enzyme that was previously thought to localize exclusively to the chloroplast. Cytoplasmic GLYK constitutes a photorespiratory bypass that alleviates fluctuating light-induced photoinhibition. Therefore, phytochrome controls alternative promoter selection to modulate protein localization in response to changing light conditions. This study suggests that alternative promoter usage represents anotherubiquitous layer of gene expression regulation in eukaryotes that contributes to diversification of the proteome.

リンク情報
DOI
https://doi.org/10.1016/j.cell.2017.10.018
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000417362700014&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.cell.2017.10.018
  • ISSN : 0092-8674
  • eISSN : 1097-4172
  • Web of Science ID : WOS:000417362700014

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