Atsushi Mochizuki

Profile Information

Affiliation: Professor, Institute for Frontier Life and Medical Sciences, Kyoto University

Degree: Ph. D. in Science(Mar, 1996, Kyushu University)
Master degree in Science(Oct, 1999, Kyushu University)

ORCID ID: https://orcid.org/0000-0002-7714-1755
J-GLOBAL ID: 200901025503069114
Researcher ID: A-7917-2015
researchmap Member ID: 1000266156

External link: https://mathbio.infront.kyoto-u.ac.jp/en/

Atsushi Mochizuki graduated from the Faculty of Sciences, Kyoto University, in 1994, and obtained his PhD in 1999 from Kyushu University. He was promoted to assistant professor in 1998 at Kyushu University, to associate professor in 2002 at National Institute for Basic Biology, to chief scientist in 2008, and to professor in 2018 at Kyoto University. His researches focus on the mathematical and computational studies on biological phenomena in molecular and developmental biology. One of his largest achievements is to establish "Structural Theories for Network Systems", by which important aspects of dynamical properties of complex systems are determined from topologies of networks alone. He was awarded 11th JSPS PRIZE (2015) from Japan Society for the Promotion of Science.

Research Interests

Research Areas

Research History

Apr, 2018 - Present

Professor, Institute for Frontier Life and Medical Sciences, Kyoto University
Aug, 2008 - Mar, 2020

Chief Scientist, Theoretical Biology Laboratory, RIKEN
Sep, 2002 - Jun, 2008

Associate Professor, Division of Theoretical Biology, National Institute for Basic Biology
Jul, 1998 - Aug, 2002

Assistant Professor, Faculty of Sciences Department of Biology, Kyushu University
Apr, 1998 - Jun, 1998

JSPS Fellow, Kyushu University

Education

Apr, 1994 - Mar, 1998

Department of Biology, Graduate School of Sciences, Kyushu University
- Mar, 1994

Faculty of Science, Kyoto University

Committee Memberships

2020 - 2026

Strategic Basic Research Programs, PRESTO, Advisor, JST
2020 - 2020

Organize Committee of Annual Meeting, Molecular Biology Society of Japan
2012 - 2020

Strategic Basic Research Programs, CREST, Advisor, JST
2019 - 2019

Organize Committee of Annual Meeting, Molecular Biology Society of Japan
2017 - 2018

Committee, Japanese Society for Mathematical Biology
2012 - 2018

Strategic Basic Research Programs, PRESTO, Advisor, JST
2011 - 2013

Committee, Japanese Society for Mathematical Biology
2005 - 2006

Committee, Japanese Society for Mathematical Biology
2001 - 2002

Committee, Japanese Society for Mathematical Biology

Awards

Feb, 2015

11th JSPS PRIZE, Study for the Relation between the Dynamics and Structure of Regulatory Networks in Biology, JSPS

Atsushi Mochizuki
Dec, 2017

1st MIMS Mimura Award, Structural theories for determining dynamical behaviors of biological network systems, Meiji Institute for Advanced Study of Mathematical Sciences (MIMS)

Atsushi Mochizuki

Papers

Finding regulatory modules of chemical reaction systems

Yuhei Yamauchi, Atsuki Hishida, Takashi Okada, Atsushi Mochizuki

Oct 16, 2023
Position of meristems and the angles of the cell division plane regulate the uniqueness of lateral organ shape.

Ayaka Kinoshita, Makiko Naito, Zining Wang, Yasuhiro Inoue, Atsushi Mochizuki, Hirokazu Tsukaya

Development (Cambridge, England), 149(23), Nov 14, 2022
The gene regulatory system for specifying germ layers in early embryos of the simple chordate

Miki Tokuoka, Kazuki Maeda, Kenji Kobayashi, Atsushi Mochizuki, Yutaka Satou

Science Advances, 7(24) eabf8210-eabf8210, Jun, 2021
Using linkage logic theory to control dynamics of a gene regulatory network of a chordate embryo.

Kenji Kobayashi, Kazuki Maeda, Miki Tokuoka, Atsushi Mochizuki, Yutaka Satou

Scientific reports, 11(1) 4001-4001, Feb 17, 2021
Author Correction: Pyrophosphate inhibits gluconeogenesis by restricting UDP-glucose formation in vivo (Scientific Reports, (2018), 8, 1, (14696), 10.1038/s41598-018-32894-1)

Ali Ferjani, Kensuke Kawade, Mariko Asaoka, Akira Oikawa, Takashi Okada, Atsushi Mochizuki, Masayoshi Maeshima, Masami Yokota Hirai, Kazuki Saito, Hirokazu Tsukaya

Scientific Reports, 9(1) 7848-7848, Dec 1, 2019 Peer-reviewed
A Rho-based reaction-diffusion system governs cell wall patterning in metaxylem vessels

Yoshinobu Nagashima, Satoru Tsugawa, Atsushi Mochizuki, Takema Sasaki, Hiroo Fukuda, Yoshihisa Oda

Scientific Reports, 8(1) 11542-11542, Dec 1, 2018 Peer-reviewed
Pyrophosphate inhibits gluconeogenesis by restricting UDP-glucose formation in vivo

Ali Ferjani, Kensuke Kawade, Mariko Asaoka, Akira Oikawa, Takashi Okada, Atsushi Mochizuki, Masayoshi Maeshima, Masami Yokota Hirai, Kazuki Saito, Hirokazu Tsukaya

Scientific Reports, 8(1) 14696, Dec 1, 2018 Peer-reviewed
Caspases and matrix metalloproteases facilitate collective behavior of non-neural ectoderm after hindbrain neuropore closure

Naomi Shinotsuka, Yoshifumi Yamaguchi, Kenichi Nakazato, Yudai Matsumoto, Atsushi Mochizuki, Masayuki Miura

BMC Developmental Biology, 18(1) 17-17, Jul 31, 2018 Peer-reviewed
Structural bifurcation analysis in chemical reaction networks

Okada Takashi, Tsai Je-Chiang, Mochizuki Atsushi

PHYSICAL REVIEW E, 98(1), Jul 30, 2018 Peer-reviewed
Structural bifurcation analysis in chemical reaction networks

Takashi Okada, Je Chiang Tsai, Atsushi Mochizuki

Physical Review E, 98(1) 012417-012417, Jul 30, 2018 Peer-reviewed
Controlling Cell Fate Specification System by Key Genes Determined from Network Structure

Kenji Kobayashi, Kazuki Maeda, Miki Tokuoka, Atsushi Mochizuki, Yutaka Satou

iScience, 4 281-293, Jun 29, 2018 Peer-reviewed
Modeling the functions of condensin in chromosome shaping and segregation

Yuji Sakai, Atsushi Mochizuki, Kazuhisa Kinoshita, Tatsuya Hirano, Masashi Tachikawa

PLoS Computational Biology, 14(6) e1006152, Jun, 2018 Peer-reviewed
Measurement of caveolin-1 densities in the cell membrane for quantification of caveolar deformation after exposure to hypotonic membrane tension

Masashi Tachikawa, Nobuhiro Morone, Yosuke Senju, Tadao Sugiura, Kyoko Hanawa-Suetsugu, Atsushi Mochizuki, Shiro Suetsugu

Scientific Reports, 7(1) 7794-7794, Dec 1, 2017 Peer-reviewed
Dynamical pattern selection of growing cellular mosaic in fish retina

Noriaki Ogawa, Tetsuo Hatsuda, Atsushi Mochizuki, Masashi Tachikawa

Physical Review E, 96(3) 032416-032416, Sep 26, 2017 Peer-reviewed
Sensitivity and network topology in chemical reaction systems

Takashi Okada, Atsushi Mochizuki

Physical Review E, 96(2) 022322-022322, Aug 28, 2017 Peer-reviewed
Expected Number of Fixed Points in Boolean Networks with Arbitrary Topology

Fumito Mori, Atsushi Mochizuki

Physical Review Letters, 119(2) 028301-028301, Jul 14, 2017 Peer-reviewed
Temperature–amplitude coupling for stable biological rhythms at different temperatures

Gen Kurosawa, Atsuko Fujioka, Satoshi Koinuma, Atsushi Mochizuki, Yasufumi Shigeyoshi

PLoS Computational Biology, 13(6) e1005501, Jun, 2017 Peer-reviewed
Golgi apparatus self-organizes into the characteristic shape via postmitotic reassembly dynamics

Masashi Tachikawa, Atsushi Mochizuki

Proceedings of the National Academy of Sciences of the United States of America, 114(20) 5177-5182, May 16, 2017 Peer-reviewed
Controlling segregation speed of entangled polymers by their shapes

Sakai Yuji, Tachikawa Masashi, Mochizuki Atsushi

Meeting Abstracts of the Physical Society of Japan, 72 3211-3211, 2017
Controlling segregation speed of entangled polymers by the shapes: A simple model for eukaryotic chromosome segregation

Yuji Sakai, Masashi Tachikawa, Atsushi Mochizuki

Physical Review E, 94(4) 042403-042403, Oct 6, 2016 Peer-reviewed

Misc.

オートファゴソーム形成過程における膜曲率安定化因子と膜供給:物理モデルと生細胞観察による研究

小山(本田)郁子, 立川正志, 境祐二, 田村律人, 望月敦史, 水島昇

日本生化学会大会(Web), 91st, 2018
シミュレーションによるゴルジ体の自己組織化的な形成過程

立川正志, 望月敦史

実験医学, 35(14), Sep, 2017 Invited
染色体の形と分離の関係

境祐二, 境祐二, 立川正志, 望月敦史

日本物理学会講演概要集(CD-ROM), 72(1), 2017
オートファゴソーム形成の生細胞観察と物理モデル構築

小山(本田)郁子, 立川正志, 境祐二, 境祐二, 田村律人, 田村律人, 望月敦史, 水島昇

日本生化学会大会(Web), 90th, 2017
染色体の形成と分離におけるコンデンシン機能のモデル

境祐二, 境祐二, 望月敦史, 木下和久, 平野達也, 立川正志

日本数理生物学会年会(Web), 27th, 2017
Acute regulation of cell surface area by the balance between flattening and endocytosis of caveolae

SENJU Yosuke, TACHIKAWA Masashi, MOCHIZUKI Atsushi, SUETSUGU Shiro

日本細胞生物学会大会要旨集, 65th, 2013
低浸透圧によるカベオラのエンドサイトーシスと細胞の表面積の調節

千住洋介, 立川正志, 望月敦史, 末次志郎

日本生化学会大会(Web), 85th, 2012
食事性概日リズムに関する生理学・数理生物学的アプローチ

黒澤元, 望月敦史, 中村渉

日本数理生物学会大会講演要旨集, 21st, 2011
潜葉虫寄生蜂における最適採餌戦略~観察結果のシミュレーションモデルによる検証~

綾部慈子, 津田みどり, 望月敦史

日本生態学会大会講演要旨集, 55th, 2008
生命現象にみられるゆらぎ・振動・波樹状突起が空間を埋めるための自己組織化機構(Self-organizing Mechanism for Development of Space-filling Dendrites)

杉村薫, 上村匡, 望月敦史

日本発生生物学会・日本細胞生物学会合同大会要旨集, 40回・59回 25-25, May, 2007
Transcriptional autoregulation by phosphorylated and non-phosphorylated KaiC in cyanobacterial circadian rhythms

Hisako Takigawa-Imamura, Atsushi Mochizuki

Journal of Theoretical Biology, 241(2) 178-192, Jul 21, 2006 Peer-reviewed
Pattern formation of leaf veins by the positive feedback regulation between auxin flow and auxin efflux carrier

Hironori Fujita, Atsushi Mochizuki

Journal of Theoretical Biology, 241(3) 541-551, Jul 7, 2006 Peer-reviewed
Genetic addiction: Selfish gene's strategy for symbiosis in the genome

Atsushi Mochizuki, Koji Yahara, Ichizo Kobayashi, Yoh Iwasa

Genetics, 172(2) 1309-1323, Feb, 2006 Peer-reviewed
Self-organization of the vascular system in plant leaves: Inter-dependent dynamics of auxin flux and carrier proteins

Francois G. Feugier, A. Mochizuki, Y. Iwasa

Journal of Theoretical Biology, 236(4) 366-375, Oct 21, 2005 Peer-reviewed
An analytical study of the number of steady states in gene regulatory networks

Atsushi Mochizuki

Journal of Theoretical Biology, 236(3) 291-310, Oct 7, 2005 Peer-reviewed
何が細胞の多様性を作り出すのか？

蛋白質核酸酵素 2005年12月号特集「数理生物学」（編集巌佐庸）共立出版, Vol. 50 No. 15 pp. 1948-1954., 2005
数理モデルで解く発生

蛋白質核酸酵素「発生システムのダイナミクス」（上野直人・八杉貞雄・野地澄晴編）共立出版, 2005年5月号増刊 pp.785-790., 2005
生物の形態形成と数理モデル

望月敦史, MOCHIZUKI Atsushi

盛岡応用数学小研究集会報告集, 2003 19-24, Jan 1, 2004
潜葉虫の寄生蜂の探索戦略と潜孔の複雑さの関係

綾部慈子, 望月敦史, 津田みどり, 上野高敏

日本応用動物昆虫学会大会講演要旨, 48th, 2004
Possibility of tissue separation caused by cell adhesion

Ryohji Takano, Atsushi Mochizuki, Yoh Iwasa

Journal of Theoretical Biology, 221(4) 459-474, Apr, 2003 Peer-reviewed

Books and Other Publications

理論生物学 : 生命科学の新しい潮流

望月, 敦史

共立出版, 2011 (ISBN: 9784320057135)
生物の表面パターンと数理モデル

非線形・非平衡現象の数理２（三村昌泰監修）生物に見られるパターンとその起源（松下貢編）東京大学出版, 2005
生物における形づくりと細胞間相互作用 : ゼブラフィッシュ網膜の錐体モザイクを例に

望月, 敦史

[九州大学], 2002
細胞間接着・細胞間誘導による細胞の配置

生物の形づくりの数理と物理 (本多久夫編), 2000

Presentations

Controlling cell fate specification system based on network structure

MOCHIZUKI Atsushi

NetSci Satellite Symposium, May 28, 2019 Invited
Controlling cell fate specification system based on network structure

MOCHIZUKI Atsushi

International Workshop on Mathematical Biology 2019, Jan 8, 2019 Invited
Origin of Adaptation and Modularity in Chemical Reaction Networks

MOCHIZUKI Atsushi

Gordon Research Conference 2018 on Oscillations and Dynamic Instabilities in Chemical Systems, Jul 11, 2018 Invited
Structural analysis for sensitivity of chemical reaction networks

MOCHIZUKI Atsushi

International Workshop on Mathematical Biology 2018, Jan 9, 2018 Invited
Dynamical behaviors of nonlinear complex systems determined from the structure of networks

MOCHIZUKI Atsushi

Society for Mathematical Biology Meeting 2017, Jul 19, 2017 Invited
Observation and Control of Complex Nonlinear Systems Based on Network Structures

MOCHIZUKI Atsushi

BIRS Workshop "Mathematical Analysis of Biological Interaction Networks", Jun 6, 2017 Invited
Dynamics of complex biological systems determined/controlled by minimal subsets of molecules in regulatory networks

MOCHIZUKI Atsushi

NetSci Satellite Symposium, May 11, 2016 Invited
Dynamics of complex biological systems determined/controlled by minimal subsets of molecules in regulatory networks

MOCHIZUKI Atsushi

MBI Workshop IV 2016, Apr 13, 2016
Structural approach for sensitivity of chemical reaction networks

MOCHIZUKI Atsushi

MBI Workshop I 2016, Jan 27, 2016 Invited
Structural approach for sensitivity of chemical reaction networks

MOCHIZUKI Atsushi

BMB2015, Dec 3, 2015 Invited
Structural approaches for dynamics of complex network systems

MOCHIZUKI Atsushi

International Conference on Mathematical Modeling and Applications 2015, Oct 27, 2015 Invited
Structural approaches for dynamics of complex network systems

MOCHIZUKI Atsushi

2015 JSMB-CJK, Aug 27, 2015 Invited
Sensitivity of chemical reaction networks: A structural approach

MOCHIZUKI Atsushi

8th International Conference for Engineering of Chemical Complexity, Jul 3, 2015 Invited
Dynamics of complex biological systems determined/controlled by minimal subsets of molecules in regulatory networks

MOCHIZUKI Atsushi

10QTDE Colloquium on the Qualitative Theory of Differential Equations, Jul 3, 2015
Sensitivity of chemical reaction networks: A structural approach

MOCHIZUKI Atsushi

The Third BMIRC International Symposium for Virtual Physiological Human, Mar 6, 2015 Invited
Dynamics of complex biological systems determined/controlled by minimal subsets of molecules in regulatory networks

MOCHIZUKI Atsushi

10th AIMS Conference on Dynamical Systems, Differential Equations and Applications, Jul 10, 2014 Invited
Sensitivity of chemical reaction networks: a structural approach

MOCHIZUKI Atsushi

NCBS-RIKEN joint meeting for theoretical approaches in biology, May 1, 2014 Invited

Professional Memberships

Research Projects

Intrinsic periodicity of cellular systems and its modulation as the driving force be

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Jun, 2019 - Mar, 2024
Mathematical analyses for oscillatory behaviors in plants by integrating molecular dynamics and cellular mechanics

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Jun, 2019 - Mar, 2024
ネットワーク構造に基づく生命システムの恒常性創出原理の数理的解明

科学研究費助成事業基盤研究(B), 基盤研究(B), 日本学術振興会, Apr, 2019 - Mar, 2022

望月敦史
Spatiotemporal regulation of cell division axis as a grand plan of plant developmental evolution

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (S), Grant-in-Aid for Scientific Research (S), Japan Society for the Promotion of Science, May, 2016 - Mar, 2021

Hasebe Mitsuyasu
Multidimensional Exploration of Logics of Plant Development

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Jun, 2013 - Mar, 2018

Tsukaya Hirokazu, FUKAKI HIDEHIRO, ARAKI TAKASHI, KAKIMOTO TATSUO, NAKAJIMA KEIJI, HIRANO HIROYUKI
Elucidation of metabolic network underlying plant development

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Jun, 2013 - Mar, 2018

Hirai Masami, SAWADA Yuji, LI Yimeng, SAKAI Yuji, SRIYUDTHSAK Kansuporn, OKAMURA Eiji, KAWADE Kensuke, VERGARA Fredd
Development and Application of Topological Computation Theory for Dynamical Systems

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2018

Kokubu Hiroshi, HIRAOKA Yasuaki, ARAI Zin, TAKAHASHI Hiroki, SAKAJO Takashi, MOCHIZUKI Atsushi, INATSU Masaru
植物発生進化のグランドプランとしての細胞分裂軸制御機構の解明と進化

科学研究費助成事業, 基盤研究(A), 日本学術振興会, Apr, 2016 - Mar, 2017

長谷部光泰, 村田隆, 石川雅樹, 望月敦史, 小藤累美子, 玉田洋介
Design and Analysis for Dynamical Genetic Circuits based on various Mathematical Models

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Apr, 2011 - Mar, 2016

YAMAMURA Masayuki, KONAGAYA Akihiko, SUZUKI Yasuhiro, KOBAYASHI Tetsuya, MOCHIZUKI Atsushi, TAKAYASU Misako, ONO Isao, ITO Hiroshi, SEKINE Ryoji
Genetic Bases for the Evolution of Complex Adaptive Traits

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Apr, 2010 - Mar, 2016

HASEBE MITSUYASU, KURATANI SHIGERU, SHIMADA TORU, FUJIWARA HARUHIKO, KAWAGUCHI MASAYOSHI, FUKATSU TAKEMA, NISHIYAMA TOMOAKI, OKADA NORIHIRO, AGATA KIYOKAZU, KAWATA MASAKADO, GO MITIKO, TOYODA ATSUSHI, FUJIYAMA ASAO, MOCHIZUKI ATSUSHI, YAHARA TETSUKAZU
Qualitative Properties of Solutions of Differential Equations Modeling Biological Pattern Formation

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A), Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, 2006 - 2009

TAKAGI Izumi, YANAGIDA Eiji, IKEDA Hideo, NAGASAWA Takeyuki, IIDA Masato, ISHIGE Kazuhiro, UEYAMA Daishin, OGAWA Takayoshi, MOCHIZUKI Atsuhi, YAMADA Sumio
Analysis of Structure and Dynamics of Biological Information Networks

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Priority Areas, Grant-in-Aid for Scientific Research on Priority Areas, Japan Society for the Promotion of Science, 2005 - 2009

AKUTSU Tatsuya, GOTO Susumu, MOCHIZUKI Atsushi, TOKITA Keiichirou
Mathematical Approach to Nonlinear-Non-equilibrium Phenomena - Understanding of Transient Spatio-temporal Patterns-

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A), Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, 2003 - 2005

MIMURA Masayasu, MASUDA Kyuya, MOCHIZUKI Atsushi, KOBAYASHI Ryo, SENO Hiromi, EI Shin-ichiro
3次元構造を持った表皮における形態形成の数理的研究

科学研究費助成事業若手研究(B), 若手研究(B), 日本学術振興会, 2002 - 2004

望月敦史
発生におけるパターン形成の数理的研究

科学研究費助成事業特定領域研究, 特定領域研究, 日本学術振興会, 2002 - 2002

望月敦史
発生におけるパターン形成の数理的研究

科学研究費助成事業特定領域研究(C), 特定領域研究(C), 日本学術振興会, 2001 - 2001

望月敦史
Theoretical Study of Spatio-Temporal Dynamics of Synchronized Flowering and Reproduction of Trees in Forests

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2000 - 2001

IWASA Yoh, MOCHIZUKI Atsushi
Pattern formation in developmental biology and cell-cell interaction

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2000 - 2001

MOCHIZUKI Atsushi, IWASA Yo
自己組織化現象としての発生・形態形成の数理的研究

科学研究費助成事業特別研究員奨励費, 特別研究員奨励費, 日本学術振興会, 1998 - 1998

望月敦史
遺伝子ネットワークの力学的性質の解明