KOBAYASHI Atsushi

J-GLOBAL         Last updated: Aug 2, 2019 at 02:58
 
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Name
KOBAYASHI Atsushi
Nickname
小林厚志
Affiliation
Nihon University
Section
College of Engineering, Department of Chemical Biology and Applied Chemistry
Job title
Associate Professor
ORCID ID
0000-0002-3932-6863

Research Areas

 
 

Academic & Professional Experience

 
Apr 2000
 - 
Mar 2001
博士研究員, 生命工学工業技術研究所, 工業技術院
 
Apr 2001
 - 
Mar 2003
博士研究員, 独立行政法人 食品総合研究所
 
Apr 2003
 - 
Mar 2007
助手, 大学院工学研究科, 東北大学
 
Apr 2007
 - 
Mar 2015
助教, 大学院工学研究科, 東北大学
 

Awards & Honors

 
2013
科学研究費補助金 審査委員表彰, 日本学術振興会
 
Feb 2013
B.B.B.論文賞, 日本農芸化学会
 
Oct 2008
日本農芸化学会東北支部奨励賞, 日本農芸化学会東北支部
 

Published Papers

 
Hiroshi Itoh, Fabio Pichierri, and Atsushi Kobayashi
Tetrahedron Letters   58 3678-3680   Sep 2017   [Refereed]
小林厚志、星野優人、上沢七海、伊藤博
高分子論文集   75(1) 99-102   Jan 2018   [Refereed]
Atsushi Kobayashi, Hiroshi Ito, Shin-ichiro Shoda
Chemistry Letters   34 1384-1385   2005   [Refereed]
Atsushi Kobayashi, Takashi Tonozuka, Kimihiko Sato, Mikita Suyama, Jun Sasaki, Batobold Nyamdawaa, Masayoshi Sakaguchi, and Yoshiyuki Sakano
Biosci. Biotechnol. Biochem   70 495-499   2006   [Refereed]
Atsushi Kobayashi, Motomitsu Kitaoka, and Kiyoshi Hayashi
J. Biotechnol   116 227-232   2005   [Refereed]
Atsushi Kobayashi, Motomitsu Kitaoka, Kiyoshi Hayashi
Nucleic Acids Symposium Series   48 225-226   2004
A. Kobayashi, Y. Sato, F. Mizutani
Bioscience, Biotechnology, and Biochemistry   65 2392-2396   2001   [Refereed]
Unprotected N-Acetyl-2-amino Sugars – Towards One-pot Chemo-enzymatic Synthesis of Glycoproteins Catalyzed by N-Acetylglucosaminidases
Shin-ichiro Shoda, Atsushi Kobayashi, Masato Noguchi
Glycoscience: Biology and Medicine   402-409   2015   [Refereed][Invited]
Masato Noguchi, Atsushi Kobayashi, Shin-ichiro Shoda
Trends in Glycoscience and Glycotechnology   27(158) 35-42   Nov 2015   [Refereed]
Sugar oxazoline derivatives are useful donor substrates for N-acetylglucosaminidase-catalyzed glycosylation reactions. In this review, we describe the direct conversion of free sugars to their oxazoline derivatives by using water-soluble dehydrati...
Direct Introduction of Detachable Fluorescent Tag into Oligosaccharides.
Naoki Yoshida, Tsukasa Fujieda, Atsushi Kobayashi, Masaki Ishihara, Masato Noguchi, and Shin-ichiro Shoda
Chemistry Letters   42 1038-1039   2013   [Refereed]
Masato Noguchi, Tsukasa Fujieda, Wei Chun Huang, Masaki Ishihara, Atsushi Kobayashi, Shin‐ichiro Shoda
Helvetica Chimica Acta   95 1928-1936   2012   [Refereed]
Do-Hyun Im, Kei-ichi Kimura, Fumitaka Hayasaka, Tomonari Tanaka, Masato Noguchi, Atsushi Kobayashi, Shin-ichiro Shoda, Kentaro Miyazaki, Takayoshi Wakagi, Shinya Fushinobu
Bioscience, Biotechnology, and Biochemistry   76(2) 423-428   2012   [Refereed]
Masato Noguchi, Miwa Nakamura, Ayaka Ohno, Tomonari Tanaka, Atsushi Kobayashi, Masaki Ishihara, Masaya Fujita, Akiko Tsuchida, Mamoru Mizuno, Shin-ichiro Shoda
Chemical Communications   48 5560-5562   2012   [Refereed]
Naoki Yoshida, Tomonari Tanaka, Masato Noguchi, Atsushi Kobayashi, Kumiko Ishikura, Tatsuya Ikenuma, Hiromu Seno, Takeshi Watanabe, Michinari Kohri, Shin-ichiro Shoda
Chemistry Letters   41 689-698   2012   [Refereed]
Tomonari Tanaka, Tomonori Wada, Masato Noguchi, Masaki Ishihara, Atsushi Kobayashi, Takayuki Ohnuma, Tamo Fukamizo, Ryszard Brzezinski & Shin-ichiro Shoda
Journal of Carbohydrate Chemistry   31 634-646   2012   [Refereed]
p-Nitrophenyl β-glycosides of β-1,4-gluco/xylo-disaccharides for the characterization of submits in endo-xylanases.
Mamoru Nishimoto, Atsushi Kobayashi, Yuji Honda, Motomitsu Kitaoka, Kiyoshi Hayashi
Journal of Applied Glycoscience   58 115-118   Sep 2011   [Refereed]
Direct dehydrative pyridylthio-glycosidation of unprotected sugars in aqueous media using 2-chloro-1,3-dimethylimidazolium chloride as a condensing agent.
Naoki Yoshida, Masato Noguchi, Tomonari Tanaka, Takeshi Matsumoto, Naoya Aida, Masaki Ishihara, Atsushi Kobayashi, Shin‐ichiro Shoda
Chemistry An Asian Journal   6 1876-1885   Jul 2011
4,6-Dimethoxy-1,3,5-triazine oligoxylogulucans: Novel one-step preparable substrates for studying action of endo-beta-1,4-glucanase III from Trichoderma reesei.
Atsushi Kobayashi, Tomonari Tanaka, Kazuhito Watanabe, Masaki Ishihara, Masato Noguchi, Hirofumi Okada, Yasushi Morikawa, and Shin-ichiro Shoda
Bioorganic and Medicinal Chemistry Letters,   20 3588-3591   2010   [Refereed]
Efficient transfer of sialo-oligosaccharide onto proteins by combined use of a glycosynthase-like mutant of Mucor hiemalis endoglycosidase and synthetic sialo-complex-type sugar oxazoline.
Midori Umekawa, Takayuki Higashiyama, Yurie Koga, Tomonari Tanaka, Masato Noguchi, Atsushi Kobayashi, Shin-ichiro Shoda, Wei Huang, Lai-Xi Wang, Hisashi Ashida, Kenji Yamamoto
Biochimica et Biophysica Acta, General Subjects   1800 1203-1209   Nov 2010   [Refereed]
Novel dialkoxytriazine-type glycosyl donors for cellulase-catalyzed lactosylation.
Tomonari Tanaka, Masato Noguchi, Kazuhito Watanabe, Takuya Misawa, Masaki Ishihara, Atsushi Kobayashi, Shin-ichiro Shoda
Organic and Biomolecular Chemistry   8 5126-5132   Nov 2010   [Refereed]
Synthesis of non-natural xyloglucans by polycondensation of 4,6-dimethoxy-1,3,5-triazin-2-yl oligosaccharide monomers catalyzed by endo-β-1,4-glucanase.
Tomonari Tanaka, Masato Noguchi, Masaki Ishihara, Atsushi Kobayashi, Shin‐ichiro Shoda
Macromolecular Symposia   297 200-209   Nov 2010   [Refereed]
Direct synthesis of 1,6-anhydro sugars from unprotected glycopyranoses by using 2-chloro-1,3-dimethylimidazolinium chloride.
Tetrahedron Letters   50 2154-2157   2009   [Refereed]
Direct transformation of unprotected sugars to aryl 1-thio-β-glycosides in aqueous media using 2-chloro-1,3-dimethylimidazolinium chloride.
Chemistry Letters   38 458-459   2009   [Refereed]
Synthesis of artificial oligosaccharides by polycondensation of 2’-O-methyl cellobiosyl fluoride and mannosyl-glucosyl fluoride catalyzed by cellulase
Interfacial researches in fundamental and material science of oligo- and polysaccharides   45-67   2009
Glycosidase-catalyzed synthesis of functional glycomaterials using SUBSTRATE ENGINEERING techniques.
Novozymes Japan Research Fund Projects 2009   9-14   Dec 2009
One-step conversion of unprotected sugars to β-glycosyl azides using 2-chloroimidazolinium salt in aqueous solution.
Chemical Communications   45 3378-3379   Jun 2009   [Refereed]
Dimethoxy Triazine Glycosides as New Glycosyl Donors for Chemo-enzymatic Synthesis of Oligosaccharides
Journal of Applied Glycoscience   56 83-86   Jun 2009
Efficient synthesis of sugar oxazolines from unprotected N-acetyl-2-amino sugars by using chloroformamidinium Reagent in Water
The Journal of Organic Chemistry   74 2210-2212   Mar 2009   [Refereed]
加水分解酵素の糖転移能を高めるための基質エンジニアリング
財団法人農芸化学研究奨励会事業報告書平成19年度   12-13   2008
A novel glycosyl donor for chemo-enzymatic oligosaccharide synthesis: 4,6-dimethoxy-1,3,5-triazin-2-yl glycoside.
Chemical Communications   44 2016-2018   2008   [Refereed]
吸光分光法を用いるフッ化糖の活性試験法
Cellulose Communications   14 58-61   Jun 2007
フッ化糖を基質とする糖加水分解酵素の新しい活性試験法
酵素工学ニュース   57 7-11   Apr 2007
Colorimetric assay for evaluating glycosyl fluoride-hydrolyzing activity of glycosidase by using alizarin complexon reagent.
Chemistry Letters   36 16-17   Jan 2007   [Refereed]
新規な遺伝子ランダム変異導入技術
ブレインテクノニュース   113 5-8   2006
多糖を温ねて新しきを知る
高分子   55 892-896   2006
A bacterial chitinase acts as catalyst for synthesis of the N-linked oligosaccharide core trisaccharide by employing a sugar oxazoline substrate.
Journal of Carbohydrate Chemistry   25 533-541   Sep 2006   [Refereed]
Stepwise synthesis of chitooligosaccharides through a transition-state analogue substrate catalyzed by mutants of chitinase A1 from Bacillus circulans WL-12.
Holzforschung   60 485-491   Aug 2006   [Refereed]
Chemo-enzymatic synthesis of novel oligo-N-acetyllactosamine derivatives having a β-(1-4)-β-(1-6) repeating unit by using transition state analogue substrate.
Cellulose   13 477-484   Aug 2006   [Refereed]
Glycosidase-catalyzed synthesis of oligosaccharides through a transition state analogue substrate
Biocatalysis: Chemistry and Biology   83-98   2005
Inactivation of α-amylases from Thermoactinomyces vulgaris R-47, TVA I and TVA II, by ω-epoxyalkyl α-D-glucopyranoside.
Journal of Applied Glycoscience   52 273-276   Sep 2005   [Refereed]
Reversible control of enzymatic transglycosylations in supercritical fluoroform using a lipid-coated β- D -galactosidase.
Journal of the American Chemical Society   124 1188-1189   Feb 2002   [Refereed]
A Lipid-coated Lipase as an Efficient Hydrolytic Catalyst in the Two-phase Aqueous-Organic System.
T. Mori, T. Fujimoto, K. Ijiro, A. Kobayashi, , Y. Okahata
Biotechnology & Bioengineering   76 175-163   2001   [Refereed]
Characterization of a thermostable family 10 endo-xylanase (XynB) from Thermotoga maritima that cleaves p-nitrophenyl-β- D -xyloside.
Journal of Bioscience and Bioengineering   92 423-428   Nov 2001   [Refereed]
超臨界流体中での酵素反応制御-超臨界フルオロフォルム中での脂質修飾リパーゼを用いた不斉選択的エステル化反応
高分子論文集   58 564-568   Nov 2001   [Refereed]
Reversible activity changes of a lipid-coated lipase for enantioselective esterification in supercritical fluoroform.
Chemical Communications   37 1832-1833   Sep 2001   [Refereed]
Biocatalytic esterification in supercritical carbon dioxide by using a lipid-coated lipase.
Toshiaki Mori, Atsushi Kobayashi, Yoshio Okahata
Chemistry Letters   921-922   1998   [Refereed]

Misc

 
Shin-ichiro Shoda, Atsushi Kobayashi, Shiro Kobayashi
White Biotechnology for Sustainable Chemistry      2016   [Invited]
分子量のそろった糖タンパク質をつくる.
正田晋一郎、小林厚志、野口真人
有機合成化学協会誌   71(12) 1252-1258   Dec 2013   [Refereed][Invited]
食べ物の化学から発展していく糖鎖工学
小林厚志・正田晋一郎
化学   65(6) 29-32   2010
糖の特性を活用する有用糖質の酵素合成
小林厚志
化学工業   61 1-8   Mar 2010
基質エンジニアリング:基質分子デザインから考える糖加水分解酵素による配糖化反応の効率化戦略
小林厚志
化学と生物   47(9) 605-616   2009   [Invited]

Books etc

 
糖鎖の新機能開発・応用ハンドブック
正田真一郎・小林厚志・野口真人 (Part:Joint Work, 第3章 糖鎖の合成-生物系 第5節 酵素合成I:加水分解酵素を利用した糖鎖合成)
NTS   Aug 2015   
クリックケミストリー
正田晋一郎・小林厚志・野口真人 (Part:Joint Work, グリコシルアジドの一段階合成)
シーエムシー出版   2014   
酵素利用技術大系~基礎・解析から改変・高機能化・産業利用まで~
正田晋一郎・小林厚志・野口真人 (Part:Joint Work, 第5編 酵素を操る、第1章 酵素を使った物質合成、第3節 糖鎖分解酵素を用いた糖鎖合成)
NTS   2010   
複合糖質の化学と最新応用技術
正田晋一郎・小林厚志・野口真人・田中知成
シーエムシー出版   2009   
セルロース利用技術の最先端
正田晋一郎・小林厚志・野口真人 (Part:Joint Work, 第7章 セルロースの酵素合成と特徴)
シーエムシー出版   Mar 2008   

Conference Activities & Talks

 
Enzymatic synthesis of glycolipid having oligosaccharides by utilizing the structural feature of amylose. [Invited]
Atsushi Kobayashi
Organic Chemistry Symposium   1 Jun 2015   
Rational design of reaction condition for the formation of glycosidic linkage catalyzed by glycosyl hydrolase: A case of α-amylase
Atsushi Kobayashi
平成29年度化学系学協会東北大会   16 Sep 2017   
Effective Chemo-enzymatic Synthesis of Glycoprotein via the Amadori Rearrangement [Invited]
Atsushi Kobayashi
International Symposium for the 70th Anniversary of the Tohoku Branch of the Chemical Society of Japan   Sep 2013   
Engineering on glycoconjugates through chemo-enzymatic process [Invited]
Atsushi Kobayashi
岩手大学 拠点形成・重点研究講演会   Feb 2014   
生命現象を理解するための糖質材料の開発 [Invited]
小林厚志
2016年度有機合成化学協会東北支部福島地区シンポジウム   7 Jul 2016   

Research Grants & Projects

 
アミノ酸配列特異的糖鎖導入と酵素法による糖蛋白質の精密ハイブリッド合成
Project Year: 2009 - 2013
高分子および界面等の難認識性基質への酵素触媒糖鎖付加反応システムのデザイン
Project Year: 2007 - 2010
糖鎖チップ・糖鎖高分子の調製のための無保護糖活性化技術の開発
新エネルギー・産業技術総合開発機構(NEDO): 
Project Year: 2006 - 2007

Education

 
Apr 1990
 - 
Mar 1994
応用生物科学科, 農学部, Tokyo University of Agriculture and Technology
 
Apr 1994
 - 
Mar 1997
応用生物科学専攻, 大学院農学研究科, Tokyo University of Agriculture and Technology
 
Apr 1997
 - 
Mar 2000
バイオテクノロジー専攻, 大学院生命理工学研究科, Tokyo Institute of Technology
 

Patents

 
2009-84181 : アンヒドロ糖及びその製造方法
2007-332029 : グリコシド誘導体の製造方法
5327945 : 配糖体及びその製造方法
5150896 : 糖鎖高分子の製造方法
5301427 : 糖オキサゾリン誘導体の製造方法