金光(髙橋) 昌史 (Atsushi Takahashi-KANEMITSU) - 論文

H. pylori CagAが惹起する細胞内シグナル撹乱の同定とその病態生理学的役割の解明

金光昌史

Japanese Journal of Helicobacter Research 27(1) 10-16 2025年5月査読有り招待有り筆頭著者最終著者責任著者

Helicobacter pyloriがんタンパク質CagAが引き起こす胃がん発症のメカニズム

金光昌史, 畠山昌則

Japanese Journal of Helicobacter Research 26(1) 12-17 2024年5月査読有り招待有り筆頭著者責任著者

20

Blueprints from plane to space: outlook of next-generation three-dimensional histopathology

Akira L Yoshikawa, Takaki Omura, Atsushi Takahashi-Kanemitsu, Etsuo A Susaki

Cancer Science 115(4) 1029-1038 2024年2月5日査読有り招待有り

34

Coevolution of the ileum with Brk/Ptk6 family kinases confers robustness to ileal homeostasis

Ippei Kikuchi, Yusuke Iwashita, Atsushi Takahashi-Kanemitsu, Michinori Koebisu, Atsu Aiba, Masanori Hatakeyama

Biochemical and Biophysical Research Communications 676 190-197 2023年10月8日査読有り

28

The Helicobacter pylori CagA oncoprotein disrupts Wnt/PCP signaling and promotes hyperproliferation of pyloric gland base cells

Atsushi Takahashi-Kanemitsu, Mengxue Lu, Christopher Takaya Knight, Takayoshi Yamamoto, Takuo Hayashi, Yusuke Mii, Takuya Ooki, Ippei Kikuchi, Akira Kikuchi, Nick Barker …

Science Signaling 16(794) eabp9020 2023年7月18日査読有り筆頭著者

49

Transgenically expressed Helicobacter pylori CagA in vascular endothelial cells accelerates arteriosclerosis in mice.

Kamurunnesa Tahmina, Narumi Hikawa, Atsushi Takahashi-Kanemitsu, Christopher T Knight, Kengo Sato, Fumiko Itoh, Masanori Hatakeyama

Biochemical and Biophysical Research Communications 618 79-85 2022年8月27日査読有り

Helicobacter pylori CagA elicits BRCAness to induce genome instability that may underlie bacterial gastric carcinogenesis

Satoshi Imai, Takuya Ooki, Naoko Murata-Kamiya, Daisuke Komura, Kamrunnesa Tahmina, Weida Wu, Atsushi Takahashi-Kanemitsu, Christopher T Knight, Akiko Kunita, Nobumi Suzuki …

Cell Host & Microbe 29 1-18 2021年6月査読有り

Alternative splicing reverses the cell-intrinsic and cell-extrinsic prooncogenic potentials of YAP1

Chi Ben, Xiaojing Wu, Atsushi Takahashi-Kanemitsu, Christopher T Knight, Takeru Hayashi, Masanori Hatakeyama

Journal of Biological Chemistry 295(41) 13965-13980 2020年8月査読有り

118

Molecular anatomy and pathogenic actions of Helicobacter pylori CagA that underpin gastric carcinogenesis

Atsushi Takahashi-Kanemitsu, Christopher T Knight, Masanori Hatakeyama

Cellular & Molecular Immunology 17 50-63 2020年1月査読有り招待有り筆頭著者

High-molecular-weight hyaluronan is a Hippo pathway ligand directing cell density-dependent growth inhibition via PAR1b

Takuya Ooki, Naoko Murata-Kamiya, Atsushi Takahashi-Kanemitsu, Weida Wu, Masanori Hatakeyama

Developmental Cell 49(4) 1-15 2019年5月査読有り

78

Transcriptional co-activator functions of YAP and TAZ are inversely regulated by tyrosine phosphorylation status of Parafibromin.

Chao Tang, Atsushi Takahashi-Kanemitsu, Ippei Kikuchi, Chi Ben, Masanori Hatakeyama

iScience 1 1-15 2018年3月査読有り

58

Dephosphorylated parafibromin is a transcriptional coactivator of the Wnt/Hedgehog/Notch pathways

Ippei Kikuchi, Atsushi Takahashi-Kanemitsu, Natsuki Sakiyama, Chao Tang, Pei-Jung Tang, Saori Noda, Kazuki Nakao, Hidetoshi Kassai, Toshiro Sato, Atsu Aiba …

Nature Communications 7 12887 2016年9月査読有り

Determination of the catalytic activity of LEOPARD syndrome-associated SHP2 mutants toward parafibromin, a bona fide SHP2 substrate involved in Wnt signaling

Saori Noda, Atsushi Takahashi, Takeru Hayashi, Sei-ichi Tanuma, Masanori Hatakeyama

Biochemical and Biophysical Research Communications 469(4) 1133-1139 2016年1月査読有り

YAP and TAZ, Hippo Signaling Targets, Act as a Rheostat for Nuclear SHP2 Function

Ryouhei Tsutsumi, Mohammad Masoudi, Atsushi Takahashi, Yumiko Fujii, Takeru Hayashi, Ippei Kikuchi, Yumeko Satou, Masanori Taira, Masanori Hatakeyama

Developmental Cell 26(6) 658-665 2013年9月査読有り

SHP2 Tyrosine Phosphatase Converts Parafibromin/Cdc73 from a Tumor Suppressor to an Oncogenic Driver

Atsushi Takahashi, Ryouhei Tsutsumi, Ippei Kikuchi, Chikashi Obuse, Yasuhiro Saito, Azadeh Seidi, Robert Karisch, Minerva Fernandez, Taewoo Cho, Naomi Ohnishi …

Molecular Cell 43(1) 45-56 2011年7月査読有り筆頭著者

Isolation of a distinct class of gain-of-function SHP-2 mutants with oncogenic RAS-like transforming activity from solid tumors

Daisuke Miyamoto, M Miyamoto, Atsushi Takahashi, Yasuhiro Yomogita, Hideaki Higashi, S Kondo, Masanori Hatakeyama

Oncogene 27(25) 3508-3515 2008年6月査読有り

Focal adhesion kinase is a substrate and downstream effector of SHP-2 complexed with Helicobacter pylori CagA

Ryouhei Tsutsumi, Atsushi Takahashi, Takeshi Azuma, Hideaki Higashi, Masanori Hatakeyama

Molecular and Cellular Biology 26(1) 261-276 2006年1月査読有り

Helicobacter pylori CagA induces Ras-independent morphogenetic response through SHP-2 recruitment and activation

Hideaki Higashi, Akihiro Nakaya, Ryouhei Tsutsumi, Kazuyuki Yokoyama, Yumiko Fujii, Susumu Ishikawa, Megumi Higuchi, Atsushi Takahashi, Yo Kurashima, Yasuhiro Teishikata …

Journal of Biological Chemistry 279(17) 17205-17216 2004年4月査読有り

金光(髙橋) 昌史

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